Výsledky vyhledávání - "Sair Maximo Chavez-Pacheco"

Fragment merging strategies with known pyrimidine scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis

Autor: Tim Kirkman, Suk Fun Tan, Sair Maximo Chavez Pacheco, Alexander Hammer, Manuela Tosin, Anthony Coyne, Marcio Dias

Publikováno v: ChemMedChem.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07205df6190cd3bd116440792cbded7f
https://doi.org/10.1002/cmdc.202300240

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Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis

Autor: Petros A. Tyrakis, Marcio Vinicius Bertacine Dias, J.A. Ribeiro, Maurício L. Sforça, Silvana A. Rocco, Tom L. Blundell, Anthony G. Coyne, Roberto Parise-Filho, Gabriel S. de Oliveira, Sair Maximo Chavez-Pacheco, Timothy Kirkman, Chris Abell, Alexander Hammer, Jamal El Bakali, G.A. Libreros-Zuniga

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Made available in DSpace on 2020-12-10T20:10:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-14 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Bill & Melinda Gates Foundation Conselho Nacional de Desenvolvimento Cient�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adefd9fb33513d13efa66f3cced5b24e
https://doi.org/10.1021/acsinfecdis.0c00263

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Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis

Autor: Timothy Kirkman, Chris Abell, Sair Maximo Chavez-Pacheco, Tom L. Blundell, Silvana A. Rocco, Anthony G. Coyne, Petros A. Tyrakis, J.A. Ribeiro, Gerardo Andrés Libreros Zúñiga, Maurício L. Sforça, Alexander Hammer, Roberto Parise-Filho, Jamal El Bakali, Marcio Vinicius Bertacine Dias, Gabriel S. de Oliveira

Dihydrofolate reductase (DHFR), a key enzyme involved in folate metabolism, is a widely explored target in the treatment of cancer, immune diseases, bacteria and protozoa infections. Although several antifolates have proved successful in the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff6acff8ed14e9e2e3b04f257bba2f2
https://doi.org/10.1101/2020.03.30.016204

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Folate biosynthesis pathway: mechanisms and insights into drug design for infectious diseases

Autor: Sair Maximo Chavez-Pacheco, G.A. Libreros-Zuniga, Jademilson C. Santos, Marcio Vinicius Bertacine Dias, J.A. Ribeiro

Publikováno v: Future Medicinal Chemistry. 10:935-959

Folate pathway is a key target for the development of new drugs against infectious diseases since the discovery of sulfa drugs and trimethoprim. The knowledge about this pathway has increased in the last years and the catalytic mechanism and structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c41cb9b2eb41adda6106ef5b76c50f
https://doi.org/10.4155/fmc-2017-0168

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Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis

Autor: Tabata P. Cardoso, Priscila dos Santos Bury, Sair Maximo Chavez-Pacheco, Larissa Antelo de Sá, Marcio Vinicius Bertacine Dias

Made available in DSpace on 2018-11-26T17:31:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56e0a137923c4ed2cff414686b71c2
https://doi.org/10.1016/j.pep.2017.01.001

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Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates

Autor: João Augusto Ribeiro, Sair Maximo Chavez-Pacheco, Gabriel Stephani de Oliveira, Catharina dos Santos Silva, João Henrique Pimenta Giudice, Gerardo Andres Libreros-Zúñiga, Marcio Vinicius Bertacine Dias

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2019-10-04T12:14:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Tuberculosis is a disease caused by Mycobacterium tuberculosis and is the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec3579f98fb8e1dc4f356f6e5351510
https://pubmed.ncbi.nlm.nih.gov/31282477

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Estudo da resistência à isoniazida em Mycobacterium tuberculosis: uma caracterização estrutural e biofísica de mutações missense no gene inhA identificados a partir de isolados clínicos

Autor: Sair Maximo Chavez Pacheco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c73814b40cbc34b5f9c6fb907fcfcd3
https://doi.org/10.11606/d.42.2018.tde-09042018-171215

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Study of resistance to isoniazid in Mycobacterium tuberculosis: structural and biophysical characterization of missense mutations of the inhA gene identified in resistant clinical isolates

Autor: Sair Maximo Chavez Pacheco

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

A tuberculose, causada por Mycobacterium tuberculosis, ainda é uma emergência de saúde pública global. O surgimento das cepas multirresistentes (MDR) e das cepas extensivamente resistentes (XDR) agravam a situação, diminuindo o número de fárm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::b9d5615bea68f27ee5429ac09653523a

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