Výsledky vyhledávání - "Saioa Domínguez-Hormaetxe"

Data from OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models

Autor: Manuel Hidalgo, Laureano Simon, Wolfgang Richter, Muhammad Abbas, Sofia Perea, Pedro P. López-Casas, María dM. Vivanco, So Young Lee, Klaus Pfizenmaier, Roland E. Kontermann, Stephan A. Eisler, Oliver Seifert, Laura Murias, Bruno Bockorny, Saioa Domínguez-Hormaetxe, Cristina Ferrer, Myriam Fabre

Purpose:The tumor microenvironment plays a key role in cancer development and progression and is involved in resistance to chemo- and immunotherapy. Cancer-associated fibroblast expressing fibroblast-activating protein α (FAPα) is one of the predom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6797b2d398722f17175c2a20b0b727
https://doi.org/10.1158/1078-0432.c.6529635

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Supplementary Materials and Methods from OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models

Additional Materials and Methods information not included in the article text, and detailed description of the patient tumors from which xenograft models have been derived from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1113ff1b2ff565225de38899d061706f
https://doi.org/10.1158/1078-0432.22477371

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Supplementary Figures from OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models

S1-S7 all supplementary figures with their legends: S1:Figure S1. OMTX705 binding and internalization in HT1080-WT, -FAP and CAFs S2:Weight change of mice bearing Panc 007, Lung 024 and Breast 014 tumors. S3: OMTX705 Activity in the Immunodeficient P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f9fb6f8e368c85f24adf38066bebff
https://doi.org/10.1158/1078-0432.22477374.v1

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Expression of Epithelial and Mesenchymal Markers in Plasmatic Extracellular Vesicles as a Diagnostic Tool for Neoplastic Processes

Autor: Begoña O. Alen, Lara Sofía Estévez-Pérez, María Otero Alén, Saioa Domínguez Hormaetxe, Laureano Simón, Ángel Concha

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3578

Tumor-derived extracellular vesicles (TD-EVs) have active roles as cancer hallmark enablers. EVs RNA of epithelial and stromal cells carry information that facilitates the communication processes that contribute to oncological progression, so the obj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaee0a94ca72f6dabcc0e1b0473073e3
https://doi.org/10.3390/ijms24043578

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OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models

Autor: Roland E. Kontermann, Myriam Fabre, Stephan A. Eisler, So Young Lee, Oliver Seifert, Sofia Perea, Laura Murias, Muhammad Abbas, Saioa Domínguez-Hormaetxe, Bruno Bockorny, Klaus Pfizenmaier, Maria dM Vivanco, Manuel Hidalgo, Pedro P. López-Casas, Laureano Simon, Wolfgang F. Richter, Cristina Ferrer

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 26(13)

Purpose: The tumor microenvironment plays a key role in cancer development and progression and is involved in resistance to chemo- and immunotherapy. Cancer-associated fibroblast expressing fibroblast-activating protein α (FAPα) is one of the predo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c05e67c54d5ed35542022803c7a6aba
https://pubmed.ncbi.nlm.nih.gov/32161121

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Collagen, type XI, alpha 1: an accurate marker for differential diagnosis of breast carcinoma invasiveness in core needle biopsies

Autor: Saray Pereda, Laureano Simon, Javier Freire, Javier Gómez-Román, Saioa Domínguez-Hormaetxe, Ana de Juan, Alfonso Vega

Publikováno v: Pathology, research and practice. 210(12)

Accurate diagnosis of invasive breast lesions, when analyzed by Core Needle Biopsy, may suppose a major challenge for the pathologist. Various markers of invasiveness such as laminin, S-100 protein, P63 or calponin have been described; however, none

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d97bcd39f76ec1bdeb566e6eea6a64
https://pubmed.ncbi.nlm.nih.gov/25175819

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Pro-COL11A1: A biomarker to predict malignant relapse of breast intraductal papillomas

Autor: Angela Hens, Javier Gómez-Román, Javier Freire, Ana Montes, Lucia García-Berbel, Laureano Simon, Saray Pereda, Saioa Domínguez-Hormaetxe, Ana de Juan

Publikováno v: Journal of Clinical Oncology. 31:540-540

540 Background: Breast cancer is currently the most frequent tumor among women. Despite the huge progress achieved in its early diagnosis, there are still many unsolved clinical issues, being the diagnosis, prognosis and treatment of papillary diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8797350e90f6ecdd6905202137e07caa
https://doi.org/10.1200/jco.2013.31.15_suppl.540

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