Výsledky vyhledávání - "Saima J. Wase"

OBIF: an omics-based interaction framework to reveal molecular drivers of synergy

Autor: Jezreel Pantaleón García, Vikram V Kulkarni, Tanner C Reese, Shradha Wali, Saima J Wase, Jiexin Zhang, Ratnakar Singh, Mauricio S Caetano, Humam Kadara, Seyed Javad Moghaddam, Faye M Johnson, Jing Wang, Yongxing Wang, Scott E Evans

Publikováno v: NAR Genomics and Bioinformatics. 4

Bioactive molecule library screening may empirically identify effective combination therapies, but molecular mechanisms underlying favorable drug–drug interactions often remain unclear, precluding further rational design. In the absence of an accep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ad185634c4aeaf2ed373abf818d0b5
https://doi.org/10.1093/nargab/lqac028

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Omics-Based Interaction Framework – a systems model to reveal molecular drivers of synergy

Autor: Shradha Wali, Vikram V. Kulkarni, Tanner C. Reese, Jing Wang, Yongxing Wang, Scott E. Evans, Jezreel Pantaleón García, Ratnakar Singh, Mauricio S. Caetano, Faye M. Johnson, Saima J. Wase, Seyed Javad Moghaddam, Jiexin Zhang

Bioactive molecule library screening strategies may empirically identify effective combination therapies. However, without a systems theory to interrogate synergistic responses, the molecular mechanisms underlying favorable drug-drug interactions rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7883184d92a8237f67de80441bb17290
https://doi.org/10.1101/2020.04.16.041350

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Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway

Autor: Sriharsha Voleti, Mohammad Y. Ansari, Tariq M. Haqqi, Saima J. Wase, Nashrah Ahmad, Kimberly Novak

Publikováno v: J Cell Sci

Mitochondrial function is impaired in osteoarthritis (OA) but its impact on cartilage catabolism is not fully understood. Here, we investigated the molecular mechanism of mitochondrial dysfunction-induced activation of the catabolic response in chond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61703796a9fdf09fff5d576fef139618
https://pubmed.ncbi.nlm.nih.gov/33097606

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Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c

Autor: Saima J. Wase, Hope C. Ball, Mohammad Y. Ansari, Tariq M. Haqqi, Kimberly Novak

Publikováno v: Osteoarthritis Cartilage

Summary Objective Lysosomes are the major catabolic organelle of the cell and regulate the macromolecular and organelle turnover and programmed cell death. Here, we investigated the lysosome dysfunction in cartilage and its role in chondrocytes apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b09668a55d8dccf1871d1d4213091b
https://pubmed.ncbi.nlm.nih.gov/33161099

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Mitochondrial dysfunction in osteoarthritis and aged cartilage triggers inflammatory response and matrix degradation via ros mediated activation of JNK-MAPK/cFos-AP1 axis in chondrocytes

Autor: Saima J. Wase, Kimberly Novak, M. Malik, S. Voleti, Mohammad Y. Ansari, Nashrah Ahmad, Tariq M. Haqqi

Publikováno v: Osteoarthritis and Cartilage. 28:S187

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e6b1a5d09d8b2b42f7f9ebe3f7876e4
https://doi.org/10.1016/j.joca.2020.02.304

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