Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Saili Yi"'
Autor:
Swetha Pendem, Igor Mikaelian, Sarani Ghoshal, Anna Zagorska, Archana Vijayakumar, Katie Walker, Bryan C. Fuchs, Robert Brockett, K. Liu, Bruno Marchand, David Lopez, David G. Breckenridge, Li Li, Ricardo Ramirez, Jamie Bates, Saritha Kusam, Dmytro Kornyeyev, Saili Yi, David Newstrom, David Hollenback
Publikováno v:
Journal of Hepatology. 73:896-905
Background & Aims Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step of de novo lipogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e3434ea9bae5e5487db79bd3c5389
https://doi.org/10.1016/j.jhep.2020.04.037
https://doi.org/10.1016/j.jhep.2020.04.037
Autor:
Mischa Hepner, Anita Mathias, Saili Yi, Cara H. Nelson, David Breckenridge, Kim Etchevers, John Ling, Uptal D. Patel
Publikováno v:
Clinical pharmacokinetics. 59(9)
Selonsertib is a first-in-class inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with therapeutic potential for fibrotic diseases. This phase I study evaluated the safety, tolerability, pharmacokinetics (PK), and food effect of selonsertib in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6218241b2d5e9074da45c7f1075ebf
https://pubmed.ncbi.nlm.nih.gov/32333325
https://pubmed.ncbi.nlm.nih.gov/32333325
Autor:
Jianmin Fang, Saili Yi, James P. Allison, Jennifer Creson, Andrew Simmons, Marina Moskalenko, Melinda VanRoey, Karin Jooss
Publikováno v:
Cancer Immunology, Immunotherapy. 57:1263-1270
Promising anti-tumor responses have been observed in the clinic using monoclonal antibodies (mAbs) that block immune checkpoints. One concern with these therapeutic agents remains the potential induction of immune breakthrough events (IBEs) resulting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1571c673c8372ca5bcb895b6696481b9
https://doi.org/10.1007/s00262-008-0451-3
https://doi.org/10.1007/s00262-008-0451-3
Autor:
Thomas Harding, Melinda VanRoey, Andrew Simmons, Karin Jooss, Guang Huan Tu, Jianmin Fang, Saili Yi, Minh Nguyen
Publikováno v:
Molecular Therapy. 15(6):1153-1159
Monoclonal antibody (mAb) delivery by gene transfer in vivo may be an attractive alternative to current mAb therapies for applications that require long-term therapy. This article describes a transfer system that allows inducible high-level expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b127d8c51bb81b83f4c8e155afdbd1
Autor:
David von Schack, Daniel J. Chin, Valérie Vincent, Joseph C. Murray, Roman Urfer, László Patthy, Scott Lohr, Shiming Ye, Kristin Anton, Alan Chu, Li Gan, Saili Yi, Karoly Nikolich, Mirella Gonzalez-Zulueta
Publikováno v:
Journal of Biological Chemistry. 279:5565-5572
Alzheimer's disease is a progressive neurodegenerative disease characterized by senile plaques, neurofibrillary tangles, dystrophic neurites, and reactive glial cells. Activated microglia are found to be intimately associated with senile plaques and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe087021e1b5c4f84cc99ed5e5b963d
https://doi.org/10.1074/jbc.m306183200
https://doi.org/10.1074/jbc.m306183200
Autor:
Roger F. Castilho, Thorsten Melcher, Mirella Gonzalez-Zulueta, Gregor Tomasevic, Gunilla Gidö, Karoly Nikolich, Gustav Mattiasson, Mehrdad Shamloo, Tadeusz Wieloch, Kavitha Mathi, Saili Yi, Craig H Warden
Publikováno v:
Nature Medicine. 9:1062-1068
Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9233d8c9ac797d48235fc8a5e4739249
https://doi.org/10.1038/nm903
https://doi.org/10.1038/nm903
Autor:
Saili Yi
Publikováno v:
2010 International Conference on Mechanic Automation and Control Engineering.
In this paper, based on the literature review and research to the large numbers of available data, the status in quo about the urban wastewater treatment technology in china was summarized and analyzed from the points of view of sustainable developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd0c35737461c9f57ba197525edee6f
https://doi.org/10.1109/mace.2010.5536175
https://doi.org/10.1109/mace.2010.5536175
Autor:
Jianyong Shi, Saili Yi
Publikováno v:
2009 WRI Global Congress on Intelligent Systems.
In this paper, an agent-based simulation model is presented to simulate occupant evacuation in fire environment. Based on the agent technology, a computer program is developed to simulate and analyze the egress progress in large public buildings. Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ff63b8887d3dc4c2d431a8aab42ace9
https://doi.org/10.1109/gcis.2009.442
https://doi.org/10.1109/gcis.2009.442
Autor:
Saili Yi, Li Gan, Lin Feng Chen, Yungui Zhou, Lennart Mucke, Jennifer Y. Chen, Sarah Mueller-Steiner, Hakju Kwon
Publikováno v:
The Journal of biological chemistry. 280(48)
Accumulating evidence suggests that neurodegeneration induced by pathogenic proteins depends on contributions from surrounding glia. Here we demonstrate that NF-kappaB signaling in microglia is critically involved in neuronal death induced by amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b87f0731312d14d3209c04bc79854f2
https://pubmed.ncbi.nlm.nih.gov/16183991
https://pubmed.ncbi.nlm.nih.gov/16183991
Publikováno v:
American Journal of Industrial Medicine. 17:84-85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dbc47ae636a9e17f6199c8810ae08d5
https://doi.org/10.1002/ajim.4700170123
https://doi.org/10.1002/ajim.4700170123