Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sailesh Palikhe"'
Autor:
Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato, Marie E. Migaud, Katsuhiko Ishihara, Hisashi Mori, Takashi Nakagawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a cruc
Externí odkaz:
https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1
Autor:
Sailesh Palikhe, Wakana Ohashi, Takuya Sakamoto, Kohshi Hattori, Masaaki Kawakami, Tsugunobu Andoh, Hiromi Yamazaki, Yuichi Hattori
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identifi
Externí odkaz:
https://doaj.org/article/7775a0a1f72d43e08dfb0ea95cccfddd
Autor:
Sailesh Palikhe, Udval Uuganbayar, Hoang Kim Tu Trinh, Ga-Young Ban, Eun-Mi Yang, Hae-Sim Park, Seung-Hyun Kim
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane. Those metabolites pl
Externí odkaz:
https://doaj.org/article/941cbb0f6f884ee0a30ea0814c108081
Autor:
Mariam Karim, Keisuke Yaku, Yasuhito Nitta, Tooba Iqbal, Marie E. Migaud, Hisashi Mori, Hironori Izumi, Atsushi Sato, Katsuhiko Ishihara, Keisuke Hikosaka, Faisal Hayat, Sailesh Palikhe, Takashi Nakagawa, Tomoyuki Yoshida
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Nicotinamide riboside (NR) is one of the orally bioavailable NAD+ precursors and has been demonstrated to exhibit beneficial effects against aging and aging-associated diseases. However, the metabolic pathway of NR in vivo is not yet fully understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ac7c5e07bd3c99c46eb78801a123b3
https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1
https://doaj.org/article/a876a5bfafc342e5ae46b26347552ed1
Autor:
Samar Imbaby, Hiroki Yokoo, Yuichi Hattori, Kohshi Hattori, Naoyuki Matsuda, Sailesh Palikhe, Kengo Tomita
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Sepsis is a major clinical challenge with unacceptably high mortality. The signal transducers and activators of transcription (STAT) family of transcription factors is known to activate critical mediators of cytokine responses, and, among this family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cdc82f4b08e3ffe18e30ce49524b51
http://link.springer.com/article/10.1038/s41598-020-72136-x
http://link.springer.com/article/10.1038/s41598-020-72136-x
Autor:
Sailesh Palikhe, Takashi Nakagawa
Publikováno v:
Aging Mechanisms II ISBN: 9789811679766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624dd0c67be95ffd478fdf9a711e4911
https://doi.org/10.1007/978-981-16-7977-3_8
https://doi.org/10.1007/978-981-16-7977-3_8
Publikováno v:
European Journal of Pharmacology. 833:403-410
Despite advances in overall medical care, sepsis and its sequelae continue to be an embarrassing clinical entity with an unacceptably high mortality rate. The central reason for high morbidity and high mortality of sepsis and its sequelae is the lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccad1e8a273c8aea35386b136548c920
https://doi.org/10.1016/j.ejphar.2018.06.031
https://doi.org/10.1016/j.ejphar.2018.06.031
Autor:
Yuichi Hattori, Sailesh Palikhe, Naoyuki Matsuda, Wakana Ohashi, Kengo Tomita, Takahiro Imaizumi, Kohshi Hattori
Publikováno v:
Critical Care Medicine. 46:e435-e442
Objectives Inflammation and apoptosis are decisive mechanisms for the development of end-organ injury in sepsis. Activator protein-1 may play a key role in regulating expression of harmful genes responsible for the pathophysiology of septic end-organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b77b1a886c9300e66e89d7eb06fa5d0
https://doi.org/10.1097/ccm.0000000000003009
https://doi.org/10.1097/ccm.0000000000003009
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO2-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819e593519dd3532b8af71cccc03d6b9
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-5-8
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-5-8
Autor:
Yuichi Hattori, Kohshi Hattori, Naoyuki Matsuda, Shigeyuki Yamashita, Sailesh Palikhe, Mari Sakai, Tokiko Suzuki, Kengo Tomita, Naoki Yoshimura
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H1224-H1237
Dobutamine has been used in septic shock for many years as an only inotrope, but its benefit has been questioned. We weighed the effects of dobutamine and milrinone as inotropes in mice with cecal ligation and puncture (CLP)-induced polymicrobial sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8945cc9e287f39d2fe7668da8e29f8
https://doi.org/10.1152/ajpheart.00828.2016
https://doi.org/10.1152/ajpheart.00828.2016