Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer

Autor: Qingxiang Lin, Shichen Shen, Zhicheng Qian, Sailee S. Rasam, Andrea Serratore, William J. Jusko, Eugene S. Kandel, Jun Qu, Robert M. Straubinger

Publikováno v: Molecularcellular proteomics : MCP. 21(10)

Pancreatic adenocarcinoma (PDAC) is highly refractory to treatment. Standard-of-care gemcitabine (Gem) provides only modest survival benefits, and development of Gem resistance (GemR) compromises its efficacy. Highly GemR clones of Gem-sensitive MIAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e3cc94e26dafbc4e32e7908aa99cd
https://pubmed.ncbi.nlm.nih.gov/36084875

Highly Reproducible Quantitative Proteomics Analysis of Pancreatic Cancer Cells Reveals Proteome-Level Effects of a Novel Combination Drug Therapy That Induces Cancer Cell Death via Metabolic Remodeling and Activation of the Extrinsic Apoptosis Pathway.

Autor: Rasam S; Department of Biochemistry, University at Buffalo, Buffalo, New York 14260, United States.; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States., Lin Q; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, United States.; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York 14203, United States., Shen S; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States., Straubinger RM; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States.; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, United States.; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York 14203, United States., Qu J; Department of Biochemistry, University at Buffalo, Buffalo, New York 14260, United States.; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States.; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, United States.; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York 14203, United States.

Publikováno v: Journal of proteome research [J Proteome Res] 2023 Dec 01; Vol. 22 (12), pp. 3780-3792. Date of Electronic Publication: 2023 Oct 31.

High-quality and robust protein quantification in large clinical/pharmaceutical cohorts with IonStar proteomics investigation.

Autor: Shen S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA., Wang X; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.; AbbVie Bioresearch Center, Worcester, MA, USA., Zhu X; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA., Rasam S; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Ma M; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Huo S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA., Qian S; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Zhang M; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA., Qu M; Department of Neurology, Xuanwu Hospital, Beijing, China., Hu C; AbbVie Bioresearch Center, Worcester, MA, USA., Jin L; AbbVie Bioresearch Center, Worcester, MA, USA., Tian Y; AbbVie Bioresearch Center, Worcester, MA, USA., Sethi S; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Poulsen D; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA., Wang J; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Tu C; BioProduction Group, Thermo Fisher Scientific, Buffalo, NY, USA., Qu J; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA. junqu@buffalo.edu.

Publikováno v: Nature protocols [Nat Protoc] 2023 Mar; Vol. 18 (3), pp. 700-731. Date of Electronic Publication: 2022 Dec 09.

Cyclosporine A Modulates LSP1 Protein Levels in Human B Cells to Attenuate B Cell Migration at Low O 2 Levels.

Autor: Hilchey SP; Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA., Palshikar MG; Biophysics, Structural, and Computational Biology Program, University of Rochester Medical Center, Rochester, NY 14642, USA., Mendelson ES; Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA., Shen S; Department of Pharmaceutical Sciences, State University of New York (SUNY) at Buffalo, Buffalo, NY 14203, USA.; New York State Center of Excellence in Bioinformatics & Life Sciences, State University of New York (SUNY) at Buffalo, Buffalo, NY 14203, USA., Rasam S; Department of Pharmaceutical Sciences, State University of New York (SUNY) at Buffalo, Buffalo, NY 14203, USA.; New York State Center of Excellence in Bioinformatics & Life Sciences, State University of New York (SUNY) at Buffalo, Buffalo, NY 14203, USA., Emo JA; Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA., Qu J; Department of Pharmaceutical Sciences, State University of New York (SUNY) at Buffalo, Buffalo, NY 14203, USA.; New York State Center of Excellence in Bioinformatics & Life Sciences, State University of New York (SUNY) at Buffalo, Buffalo, NY 14203, USA., Thakar J; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA., Zand MS; Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY 14642, USA.; Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.

Publikováno v: Life (Basel, Switzerland) [Life (Basel)] 2022 Aug 22; Vol. 12 (8). Date of Electronic Publication: 2022 Aug 22.

Potential Neuroprotective Mechanisms of Methamphetamine Treatment in Traumatic Brain Injury Defined by Large-Scale IonStar-Based Quantitative Proteomics.

Autor: Shen S; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA., Zhang M; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA., Ma M; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA.; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Institute, Buffalo, NY 14203, USA., Rasam S; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA.; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA., Poulsen D; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA., Qu J; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 24; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 24.