Výsledky vyhledávání - "Saikiran Sedimbi"

Akademický článek

MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

Autor: Ada Lerma Clavero, Paula Lafqvist Boqvist, Katrine Ingelshed, Cecilia Bosdotter, Saikiran Sedimbi, Long Jiang, Fredrik Wermeling, Borivoj Vojtesek, David P. Lane, Pavitra Kannan

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Activation of p53 by small molecule MDM2 inhibitors can induce cell cycle arrest or death in p53 wildtype cancer cells. However, cancer cells exposed to hypoxia can develop resistance to other small molecules, such as chemotherapies, that ac

Externí odkaz: https://doaj.org/article/d3a15f50009a4aceacfbb783e8945359

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Data from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Autor: Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang

Inactivating p53 mutations are the most abundant genetic alterations found in cancer. Here we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient in p53 and in genes of a core CRISPR–p53 tumor suppressor interactome.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c63d65978637a6ba00b4d2840f6b1d1f
https://doi.org/10.1158/0008-5472.c.6513898.v1

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Supplementary Figure from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Autor: Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang

Supplementary Figure from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646b18f81805a689211d1d480e95d49a
https://doi.org/10.1158/0008-5472.22431412.v1

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Supplementary Table from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Autor: Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang

Supplementary Table from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574fb2ee3fdc5a8d80202b8e8efe9285
https://doi.org/10.1158/0008-5472.22431409

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Supplementary Data from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Autor: Fredrik Wermeling, David P. Lane, Saikiran Sedimbi, Zsolt Kasza, Vaishnavi Srinivasan Iyer, Sanjaykumar V. Boddul, Yunbing Shen, Katrine Ingelshed, Long Jiang

Supplementary Data from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2675c7679a4a767b8524451674b21104
https://doi.org/10.1158/0008-5472.22431415

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CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies

Autor: Long, Jiang, Katrine, Ingelshed, Yunbing, Shen, Sanjaykumar V, Boddul, Vaishnavi Srinivasan, Iyer, Zsolt, Kasza, Saikiran, Sedimbi, David P, Lane, Fredrik, Wermeling

Publikováno v: Cancer research. 82(1)

Inactivating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9122784cd2f7fbae4bc708baf8af163
https://pubmed.ncbi.nlm.nih.gov/34750099

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A 'spindle and thread' mechanism unblocks p53 translation by modulating N-terminal disorder

Publikováno v: Structure. 30:733-742.e7

Disordered proteins pose a major challenge to structural biology. A prominent example is the tumor suppressor p53, whose low expression levels and poor conformational stability hamper the development of cancer therapeutics. All these characteristics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed31ce0f39f565556e02e0e4ce74b7b5
https://doi.org/10.1016/j.str.2022.02.013

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TLR stimulation of type II NKT cells requires cell to cell contact with DCs with involvement of CD40-CD40L and IL-12p40 (INC6P.318)

Autor: Prabhanshu Tripathi, Saikiran Sedimbi, Mikael Karlsson, Ulf Yrlid, Nadir Kadri, Susanna Cardell

Publikováno v: The Journal of Immunology. 194:192.20-192.20

Natural killer T (NKT) cells are CD1d restricted innate like lymphocytes recognizing lipid antigens and mediating immune regulatory functions. NKT cells are divided into two subsets based on the type of T cell receptor (TCR) expressed. Type 1 or inva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d82a26f1ae19162b0a3e4ef0c262b66b
https://doi.org/10.4049/jimmunol.194.supp.192.20

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Invariant natural killer T (iNKT) lymphocytes promote the development of intestinal tumors (TUM2P.914)

Autor: Susanna Cardell, Ying Wang, Saikiran Sedimbi, Linda Löfbom, Steven Porcelli

Publikováno v: The Journal of Immunology. 192:71.38-71.38

CD1d-restricted NKT cells are known as potent regulatory cells of immune responses. Invariant NKT cells, which are activated by the artificial lipid ligand alpha-galactosylceramide, have anti-tumor functions in several murine experimental models, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed760f3f1c59d8095312700bb2496c6
https://doi.org/10.4049/jimmunol.192.supp.71.38

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