Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Saikiran Reddy Peddi"'
Publikováno v:
Journal of Receptors and Signal Transduction. 40:1-14
Pim-1 is one of the isoforms of pim proteins comprising pim-1, pim-2 and pim-3. It was basically recognized as proviral integration moloney murine leukemia virus which is associated with T-cell lymphomogenesis. Pim-1 is known to play a crucial role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108d6f422caf97e0734e4d53a7411785
https://doi.org/10.1080/10799893.2020.1713809
https://doi.org/10.1080/10799893.2020.1713809
Computational design, synthesis and evaluation of new sulphonamide derivatives targeting HIV-1 gp120
Publikováno v:
Journal of Computer-Aided Molecular Design. 34:39-54
Attachment of envelope glycoprotein gp120 to the host cell receptor CD4 is the first step during the human immunodeficiency virus-1 (HIV-1) entry into the host cells that makes it a promising target for drug design. To elucidate the crucial three dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15445808f69f04ae119970ca898e3908
https://doi.org/10.1007/s10822-019-00258-0
https://doi.org/10.1007/s10822-019-00258-0
Autor:
Saikiran Reddy Peddi, Santosh Karnewar, Rajeswar Rao Vedula, Krishnaiah Vaarla, Srigiridhar Kotamraju, Devayani Panuganti, Vijjulatha Manga
Publikováno v:
ChemistrySelect. 4:4324-4330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be2f8ad0330d00e6b141df29d92aac03
https://doi.org/10.1002/slct.201900077
https://doi.org/10.1002/slct.201900077
Publikováno v:
Structural Chemistry. 29:1753-1766
Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/the mammalian target of rapamycin (mTOR) signaling pathway is one of the sought after therapeutic target for treating human cancers. This pathway is often hyper activated in cancers. In the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6d2bf39cb3050c2d4ae0b395f943c3
https://doi.org/10.1007/s11224-018-1154-9
https://doi.org/10.1007/s11224-018-1154-9
Autor:
Saikiran Reddy Peddi, Narsimha Sirassu, Vijjulatha Manga, Rajitha Gali, Manjulatha Khanapur, Ramesh Gondru, Rajitha Bavantula
Publikováno v:
Molecular Diversity. 22:943-956
As a part of our endeavor toward the synthesis of a new class of biologically potent heterocyclic hybrids, a series of newly fused thiazolo[2,3-b]pyrimidinones bearing a pyrazolylcoumarin moiety (6a–p) were synthesized in acceptable yields. Anticip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02845a25355cafa801acc8c74a6433ae
https://doi.org/10.1007/s11030-018-9845-0
https://doi.org/10.1007/s11030-018-9845-0
Autor:
Ammar Adil Hussein, Nihaya Abdulsattear Mohammed, Vijjulatha Manga, Sree Kanth Sivan, Saikiran Reddy Peddi
Publikováno v:
Structural Chemistry. 29:999-1012
Human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT) plays a key in the life cycle of HIV-1. It is considered to be one of the promising targets for treating HIV/AIDS which contains two drug binding sites, a substrate binding site, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09dbacc406a91e4ed83e837bef155cc5
https://doi.org/10.1007/s11224-018-1082-8
https://doi.org/10.1007/s11224-018-1082-8
Autor:
Vijjulatha Manga, Rajeswar Rao Vedula, Raju Chedupaka, Srikanth Mamidala, Venugopal Vangala, Saikiran Reddy Peddi
Publikováno v:
Journal of Molecular Structure. 1233:130111
A series of new 1,3,4-thiadiazines were synthesized by the conventional method of dehydroacetic acid, thiocarbohydrazide and substituted phenacyl bromides or substituted 3-(2-bromoacetyl) coumarins. Structures of all the synthesized compounds were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ccd57f63d613b2d76d1652976fb00cd
https://doi.org/10.1016/j.molstruc.2021.130111
https://doi.org/10.1016/j.molstruc.2021.130111
Publikováno v:
Journal of Receptors and Signal Transduction. 36:488-504
Anaplastic lymphoma kinase (ALK), a promising therapeutic target for treatment of human cancers, is a receptor tyrosine kinase that instigates the activation of several signal transduction pathways. In the present study, in silico methods have been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3711dac72ab8f6f420b5508693d2b1a5
https://doi.org/10.3109/10799893.2015.1130057
https://doi.org/10.3109/10799893.2015.1130057
Publikováno v:
Computational biology and chemistry. 78
The fight against tuberculosis (TB) is a time immemorial one and the emergence of new drug resistant strains of Mycobacterium tuberculosis keeps throwing new challenges to the scientific community immersed in finding mechanisms to control this dreade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a853a6eaf44941178ce8aa03bf83d9d0
https://pubmed.ncbi.nlm.nih.gov/30500556
https://pubmed.ncbi.nlm.nih.gov/30500556
Publikováno v:
Journal of biomolecular structuredynamics. 36(2)
The interaction of HIV-1 transactivator protein Tat with its cognate transactivation response (TAR) RNA has emerged as a promising target for developing antiviral compounds and treating HIV infection, since it is a crucial step for efficient transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9efa7e281791189f54785ede271bc0
https://pubmed.ncbi.nlm.nih.gov/28081678
https://pubmed.ncbi.nlm.nih.gov/28081678