Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Saikiran K, Sedimbi"'
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c0c030dc1c54c61a794787a99cca008
Autor:
Joanna S. Kritikou, Mariana M.S. Oliveira, Julien Record, Mezida B. Saeed, Saket M. Nigam, Minghui He, Marton Keszei, Arnika K. Wagner, Hanna Brauner, Anton Sendel, Saikiran K. Sedimbi, Stamatina Rentouli, David P. Lane, Scott B. Snapper, Klas Kärre, Peter Vandenberghe, Jordan S. Orange, Lisa S. Westerberg
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
X-linked neutropenia (XLN) is caused by gain-of-function mutations in the actin regulator Wiskott-Aldrich Syndrome protein (WASp). XLN patients have reduced numbers of cytotoxic cells in peripheral blood; however, their capacity to kill tumor cells r
Externí odkaz:
https://doaj.org/article/c629a13a387342b6b4e5b5c45a493ae0
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of over 100 small-molecules activating p53 in cells. We
Externí odkaz:
https://doaj.org/article/c70bab1df6ec4076bb2c93aa455abeeb
Autor:
Ying Wang, Saikiran K. Sedimbi, Linda Löfbom, Gurdyal S. Besra, Steven A. Porcelli, Susanna L. Cardell
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The glycosphingolipid α-galactosylceramide (α-GalCer) is a well-described immune activator with strong anti-tumor properties in animal models. It is presented on CD1d and acts by stimulating the invariant, type I, natural killer T (iNKT) lymphocyte
Externí odkaz:
https://doaj.org/article/bf1ec3a65d76425fb970a58c40945b05
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
Navtemadlin treatment does not lead to bone marrow suppression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a90dbf8b28abaaa778aed804267ac7
https://doi.org/10.1158/2767-9764.22545461
https://doi.org/10.1158/2767-9764.22545461
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
The tumor suppressor protein p53 is mutated in close to 50% of human tumors and is dysregulated in many others, for instance by silencing or loss of p14ARF. Under steady-state conditions, the two E3 ligases MDM2/MDM4 interact with and inhibit the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000188325df54f8c15797ee060e15664
https://doi.org/10.1158/2767-9764.c.6550949.v1
https://doi.org/10.1158/2767-9764.c.6550949.v1
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
Proteomics data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11d2af10f59413e8f1e955c8d5ca61d
https://doi.org/10.1158/2767-9764.22545455.v1
https://doi.org/10.1158/2767-9764.22545455.v1
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
Complete list of proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029707c1d6bcf34612f00c36c04b3e48
https://doi.org/10.1158/2767-9764.22545458.v1
https://doi.org/10.1158/2767-9764.22545458.v1
Autor:
David Alvarez, Guillemette Masse-Ranson, Saikiran K. Sedimbi, Phylicia Wisti, Lisa Rodriguez, Jordan Santana, Taylor Manning, Tim Towner, Ben Geilich, Cosmin Mihai, Ankita Mishra, Sushma Gurumurthy, Josh Frederick, Ulrich H. von Andrian, Jonathan Hoggatt, Melissa J. Moore, J. Rodrigo Mora
Gene correction of hematopoietic stem cells (HSC) is a promising therapeutic approach for multiple disorders. Current methods, however, require HSC collection from patients, gene correction duringex vivoculture, and re-infusion of corrected HSC into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::597ff87ba90866eb90d8018250df7bb4
https://doi.org/10.1101/2022.12.15.520650
https://doi.org/10.1101/2022.12.15.520650
Autor:
Mattias N. E. Forsell, Linda Kvastad, Saikiran K. Sedimbi, John Andersson, Mikael C. I. Karlsson
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The regulation of germinal center (GC) B cell responses to single epitopes is well investigated. How monoclonal B cells are regulated within the polyclonal B cell response to protein antigens is less so. Here, we investigate the primary GC B cell res
Externí odkaz:
https://doaj.org/article/a05e7248ff14454f923c9cf73e559afe