Výsledky vyhledávání - "Saikawa Isamu"

Pyridonecarboxylic Acids as Antibacterial Agents. VI. Synthesis and Structure-Activity Relationship of 7-(Alkyl, Cycloalkyl, and Vinyl)-1-cyclopropyl-6-fluoro-4-quinolone-3-carboxylic Acids

Autor: Hirokazu Narita, Yoshikazu Fukuoka, Saikawa Isamu, Hiroyasu Takag, Yozo Todo, Fumihiko Iino, Keiichi Tanaka, Yasushi Ikeda

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:2049-2054

The title compounds (1a-i) have been synthesized starting with ethyl 1-cyclopropyl-6, 7-difluoro-4-quinolone-3-carboxylate (2). The 7-cyclopropyl and 7-vinyl derivatives (1e and 1i) exhibited potent in vitro antibacterial activities against both gram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c278dee29d6865eecf5c50174ec044
https://doi.org/10.1248/cpb.42.2049

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Pyridonecarboxylic Acids as Antibacterial Agents. IX. Synthesis and Structure-Activity Relationship of 3-Substituted 10-(1-Aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acids and Their 1-Thio and 1-Aza Analogues

Autor: Yozo Todo, Seiki Okamoto, Hiroyasu Takagi, Saikawa Isamu, Fumihiko Iino, Yoshikazu Fukuoka, Masahiro Takahata, Hirokazu Narita

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:2569-2574

A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo efficacy of 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2, 3-dihydro-7H-pyrido[1, 2, 3-de]-1, 4-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67df4520fb02bc3a5a6830d93f6a6f19
https://doi.org/10.1248/cpb.42.2569

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Pyridonecarboxylic Acids as Antibacterial Agents. VII. Synthesis and Structure-Activity Relationship of Amino- and Hydroxyl-Substituted 7-Cycloalkyl and 7-Vinyl Derivatives of l-Cyclopropyl-6-fluoro-4- quinolone-3-carboxylic Acid

Autor: Yoshikazu Fukuoka, Yasushi Ikeda, Mikako Miyajima, Yoshiko Yamashiro, Jun Nitta, Yozo Todo, Saikawa Isamu, Hirokazu Narita

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:2055-2062

Novel C(7)-derivatives of 1-cyclopropyl-6-fluoro-4-quinolone carboxylic acid (3a-o) have been synthesized and evaluated for in vitro antibacterial activity. Compounds 3e (3-aminocyclobutyl), 3g (1-aminocyclopropyl), 3m ((2-aminomethyl)vinyl), and 3o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a83991dccd8680e959672cff0efee2ea
https://doi.org/10.1248/cpb.42.2055

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Studies on the Sub-MIC of ^|^beta;-Lactam Antibiotics

Autor: Akira Yotsuji, Yasushi Ueda, Seiji Ohgaku, Naohiro Yamashita, Masahiro Takahata, Saburo Yano, Saikawa Isamu, Yasuda Takashi

Publikováno v: Journal of the Japanese Association for Infectious Diseases. 64:1499-1506

Bactericidal activity in compromised host's serum i.e. patients with cancer, the elderly, diabetes, was stronger than that in normal serum against Proteus mirabilis (P. mirabilis) but was weaker against Klebsiella pneumoniae (K. pneumoniae). Against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::970e8e36c7c22abf29acd700ad9959af
https://doi.org/10.11150/kansenshogakuzasshi1970.64.1499

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Pyridonecarboxylic acids as antibacterial agents. VIII. Synthesis and structure-activity relationship of 7-(1-aminocyclopropyl)-4-oxo-1,8-naphthyridine-3-carboxylic acids and 7-(1-aminocyclopropyl)-4-oxoquinoline-3-carboxylic acids

Autor: Nagako Nishida, Yozo Todo, Yoshiko Yamashiro, Yoshikazu Fukuoka, Jun Nitta, Saikawa Isamu, Mikako Miyajima, Hirokazu Narita

Publikováno v: Chemicalpharmaceutical bulletin. 42(10)

4-Oxo-1, 8-naphthyridine- and 4-oxoquinoline-3-carboxylic acids (2a, b and 3a-l) possessing a 1-amino-cyclopropyl group at the 7-position have been synthesized and evaluated for in vitro antibacterial activities. The three quinolones (3d, h, i) exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9f90ec399c15e83645452e66f00ff5
https://pubmed.ncbi.nlm.nih.gov/7805131

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