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Akademický článek

Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors

Autor: Xuechao Liu, Guangfeng Wang, Xianglei Yan, Haibo Qiu, Ping Min, Miaoyi Wu, Chunyang Tang, Fei Zhang, Qiuqiong Tang, Saijie Zhu, Miaozhen Qiu, Wei Zhuang, Douglas D. Fang, Zhiwei Zhou, Dajun Yang, Yifan Zhai

Publikováno v: Cell & Bioscience, Vol 9, Iss 1, Pp 1-12 (2019)

Abstract Background Imatinib shows limited efficacy in patients with gastrointestinal stromal tumors (GISTs) carrying secondary KIT mutations. HQP1351, an orally bioavailable multikinase BCR-ABL inhibitor, is currently in clinical trials for the trea

Externí odkaz: https://doaj.org/article/684f49e1df854ee8a1b2931e36258433

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Lisaftoclax (APG-2575) is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research.

Purpose: Development of B-cell lymphoma 2 (BCL-2)–specific inhibitors poses unique challenges in drug design because of BCL-2 homology domain 3 (BH3) shared homology between BCL-2 family members and the shallow surface of their protein–protein in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068284dbdeaaa9280e60219d582ece2e
https://pubmed.ncbi.nlm.nih.gov/36048524

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Integrated transcriptome and in vitro analysis revealed antiproliferative effects on human gastric cancer cells by a benzimidazole-quinoline copper(II) complex

Autor: Pingluo Xu, Wei Song, Haibo Yang, Shuangcheng Zhi, Saijie Zhu, Yan Guo

Publikováno v: Process Biochemistry. 102:286-295

Developing novel copper-based complexes as potential chemotherapeutic agents is a great challenge in antitumor medicine. In this study, we aimed to reveal a benzimidazole-quinoline copper-based complex 1 induced antitumor activity in human gastric ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b92dd14b9666df9059b38d185ad2da29
https://doi.org/10.1016/j.procbio.2021.01.009

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Abstract 3939: Preclinical development of embryonic ectoderm development (EED) inhibitor APG-5918/EEDi-5273 for cancer therapy

Autor: Saijie Zhu, Douglas D. Fang, Qiang Li, Dongmei Yang, Shoulai Gu, Shaomeng Wang, Dajun Yang, Yifan Zhai

Publikováno v: Cancer Research. 82:3939-3939

Three core components constitute the polycomb repressive complex 2 (PRC2), a multiprotein complex that catalyzes methylation of histone H3 at lysine 27 (H3K27): (1) enhancer of zeste homolog 2 (EZH2), (2) EED, and (3) suppressor of zeste 12 protein h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8635e8520de46e6fa44e2a8e9d618b68
https://doi.org/10.1158/1538-7445.am2022-3939

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Co-Amorphous Formation of High-Dose Zwitterionic Compounds with Amino Acids To Improve Solubility and Enable Parenteral Delivery

Autor: Huisheng Gao, Sudhakar Garad, Saijie Zhu, Sreehari Babu

Publikováno v: Molecular Pharmaceutics. 15:97-107

Solubilization of parenteral drugs is a high unmet need in both preclinical and clinical drug development. Recently, co-amorphous drug formulation has emerged as a new strategy to solubilize orally dosed drugs. The aim of the present study is to expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ac16ac67bdf2327144aeb3bc9c8b8d
https://doi.org/10.1021/acs.molpharmaceut.7b00738

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Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles

Autor: Michael A. Sandoval, Zhengrong Cui, Piyanuch Wonganan, Amit Kumar, Xinran Li, Saijie Zhu

Publikováno v: Journal of Controlled Release. 163:230-239

Previously, it was shown that microneedle-mediated transcutaneous immunization with plasmid DNA can potentially induce a stronger immune response than intramuscular injection of the same plasmid DNA. In the present study, we showed that the immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62987760766df7148e02417df16d4408
https://doi.org/10.1016/j.jconrel.2012.08.011

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Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells

Autor: John DiGiovanni, Woon Gye Chung, Piyanuch Wonganan, Saijie Zhu, Zhengrong Cui, Kaoru Kiguchi

Publikováno v: Cancer Biology & Therapy. 13:908-914

Gemcitabine is a deoxycytidine analog used for the treatment of a wide range of solid tumors. Its efficacy is however often reduced due to the development of resistance. Ribonucleotide reductase M1 subunit (RRM1) is a key determinant of gemcitabine r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930d5bafe40109873f46f7220b8c39ee
https://doi.org/10.4161/cbt.20843

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Lysosomal Delivery of a Lipophilic Gemcitabine Prodrug Using Novel Acid-Sensitive Micelles Improved Its Antitumor Activity

Autor: Xinran Li, Dharmika S.P. Lansakara-P, Zhengrong Cui, Saijie Zhu

Publikováno v: Bioconjugate Chemistry. 23:966-980

Stimulus-sensitive micelles are attractive anticancer drug delivery systems. Herein, we reported a novel strategy to engineer acid-sensitive micelles using a amphiphilic material synthesized by directly conjugating the hydrophilic poly(ethylene glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551697eede51ab674e320532cccafaad
https://doi.org/10.1021/bc2005945

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