Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Saija Haapa-Paananen"'
Functional profiling of precursor MicroRNAs identifies MicroRNAs essential for glioma proliferation.
Autor:
Saija Haapa-Paananen, Ping Chen, Kirsi Hellström, Pekka Kohonen, Sampsa Hautaniemi, Olli Kallioniemi, Merja Perälä
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60930 (2013)
Cancer initiation and progression involve microRNAs that can function like tumor suppressors and oncogenes. The functional significance of most miRNAs is currently unknown. To determine systematically which microRNAs are essential for glioma growth,
Externí odkaz:
https://doaj.org/article/9847307d9462448ba643a8ad57832dcd
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37922 (2012)
MuA transposase protein is a member of the retroviral integrase superfamily (RISF). It catalyzes DNA cleavage and joining reactions via an initial assembly and subsequent structural transitions of a protein-DNA complex, known as the Mu transpososome,
Externí odkaz:
https://doaj.org/article/d5d2a6fd8b7347a3b833293492b866c2
Autor:
John Patrick Mpindi, Henri Sara, Saija Haapa-Paananen, Sami Kilpinen, Tommi Pisto, Elmar Bucher, Kalle Ojala, Kristiina Iljin, Paula Vainio, Mari Björkman, Santosh Gupta, Pekka Kohonen, Matthias Nees, Olli Kallioniemi
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17259 (2011)
BACKGROUND: Meta-analysis of gene expression microarray datasets presents significant challenges for statistical analysis. We developed and validated a new bioinformatic method for the identification of genes upregulated in subsets of samples of a gi
Externí odkaz:
https://doaj.org/article/7eec0cc5ee3445ebbe76d2ab05db70dc
Autor:
John Patrick Mpindi, Henri Sara, Saija Haapa-Paananen, Sami Kilpinen, Tommi Pisto, Elmar Bucher, Kalle Ojala, Kristiina Iljin, Paula Vainio, Mari Björkman, Santosh Gupta, Pekka Kohonen, Matthias Nees, Olli Kallioniemi
Publikováno v:
PLoS ONE, Vol 6, Iss 4 (2011)
Externí odkaz:
https://doaj.org/article/1709b042c3764d2e81c500ba79ba39c7
Autor:
Saija Haapa-Paananen, Karin Mühlbacher, Anna M. Katschnig, Søren Brunak, David Westergaard, Branka Radic-Sarikas, Maximilian Kauer, Dave N. T. Aryee, Cornelia N. Mutz, Raphaela Schwentner, Kristiina Iljin, Vidal Fey, Giulio Superti-Furga, Jeffrey A. Toretsky, Heinrich Kovar, Kalliopi Tsafou
Publikováno v:
Tsafou, K, Katschnig, A M, Radic-Sarikas, B, Mutz, C N, Iljin, K, Schwentner, R, Kauer, M O, Mühlbacher, K, Aryee, D N T, Westergaard, D, Haapa-Paananen, S, Fey, V, Superti-Furga, G, Toretsky, J, Brunak, S & Kovar, H 2018, ' Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers ', OncoTarget, vol. 9, no. 57, pp. 31018-31031 . https://doi.org/10.18632/oncotarget.25760
Oncotarget
Tsafou, K, Katschnig, A M, Radic-Sarikas, B, Mutz, C N, Iljin, K, Schwentner, R, Kauer, M O, Mühlbacher, K, Aryee, D N T, Westergaard, D, Haapa-Paananen, S, Fey, V, Superti-Furga, G, Toretsky, J, Brunak, S & Kovar, H 2018, ' Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers ', Oncotarget, vol. 9, no. 57, pp. 31018-31031 . https://doi.org/10.18632/oncotarget.25760
Oncotarget
Tsafou, K, Katschnig, A M, Radic-Sarikas, B, Mutz, C N, Iljin, K, Schwentner, R, Kauer, M O, Mühlbacher, K, Aryee, D N T, Westergaard, D, Haapa-Paananen, S, Fey, V, Superti-Furga, G, Toretsky, J, Brunak, S & Kovar, H 2018, ' Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers ', Oncotarget, vol. 9, no. 57, pp. 31018-31031 . https://doi.org/10.18632/oncotarget.25760
Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the genetic hallm
Autor:
Heinrich Kovar, Didier Surdez, Jozef Ban, Maximilian Kauer, Javier Alonso, Eleni M. Tomazou, Saija Haapa-Paananen, Tao He, Kristiina Iljin, Juha Rantala, Olivier Delattre, Vidal Fey
Publikováno v:
He, T, Surdez, D, Rantala, J K, Haapa-Paananen, S, Ban, J, Kauer, M, Tomazou, E, Fey, V, Alonso, J, Kovar, H, Delattre, O & Iljin, K 2017, ' High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability ', Gene, vol. 596, pp. 137-146 . https://doi.org/10.1016/j.gene.2016.10.021
A translocation leading to the formation of an oncogenic EWS-ETS fusion protein defines Ewing sarcoma. The most frequent gene fusion, present in 85 percent of Ewing sarcomas, is EWS-FLI1. Here, a high-throughput RNA interference screen was performed
Publikováno v:
Plasmid. 86:46-53
Mu transposition-based cloning of DNA circles employs in vitro transposition reaction to deliver both the plasmid origin of replication and a selectable marker into the target DNA of interest. We report here the construction of a platform for the pur
Autor:
Anu Salminen, Saija Kiljunen, Maria Pajunen, Harri Savilahti, Elsi Pulkkinen, Saija Haapa-Paananen, Mauno Vihinen, Lars Paulin, Tiina S Rasila, Phoebe A. Rice
Publikováno v:
Nucleic Acids Research
The phage Mu DNA transposition system provides a versatile species non-specific tool for molecular biology, genetic engineering and genome modification applications. Mu transposition is catalyzed by MuA transposase, with DNA cleavage and integration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633c587de09526a4cfe4b478ea758728
http://hdl.handle.net/10138/236500
http://hdl.handle.net/10138/236500
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1681
The capacity of transposable elements to insert into the genomes has been harnessed during the past decades to various in vitro and in vivo applications. This chapter describes in detail the general protocols and principles applicable for the Mu in v
Autor:
Harri Savilahti, Saija Haapa-Paananen
Publikováno v:
Methods in Molecular Biology ISBN: 9781493973415
The capacity of transposable elements to insert into the genomes has been harnessed during the past decades to various in vitro and in vivo applications. This chapter describes in detail the general protocols and principles applicable for the Mu in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::962dd40e9375e88367640c201dea59bc
https://doi.org/10.1007/978-1-4939-7343-9_20
https://doi.org/10.1007/978-1-4939-7343-9_20