Effect of oxaliplatin plus 5-fluorouracil or capecitabine on circulating and imaging biomarkers in patients with metastatic colorectal cancer: a prospective biomarker study

Autor: Reem D. Mahmood, Danielle Shaw, Tine Descamps, Cong Zhou, Robert D. Morgan, Saifee Mullamitha, Mark Saunders, Nerissa Mescallado, Alison Backen, Karen Morris, Ross A. Little, Susan Cheung, Yvonne Watson, James P. B. O’Connor, Alan Jackson, Geoff J. M. Parker, Caroline Dive, Gordon C. Jayson

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)

Abstract Background Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of these therapies to maxim

Externí odkaz: https://doaj.org/article/357e10ddf5c4403488351151c9365ef5

Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer

Autor: Gordon C. Jayson, Cong Zhou, Alison Backen, Laura Horsley, Kalena Marti-Marti, Danielle Shaw, Nerissa Mescallado, Andrew Clamp, Mark P. Saunders, Juan W. Valle, Saifee Mullamitha, Mike Braun, Jurjees Hasan, Delyth McEntee, Kathryn Simpson, Ross A. Little, Yvonne Watson, Susan Cheung, Caleb Roberts, Linda Ashcroft, Prakash Manoharan, Stefan J. Scherer, Olivia del Puerto, Alan Jackson, James P. B. O’Connor, Geoff J. M. Parker, Caroline Dive

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colore

Externí odkaz: https://doaj.org/article/51bffec067d642f8a6e2d9a8af7b2752

The Mental Health Burden of Patients with Colorectal Cancer Receiving Care during the COVID-19 Pandemic: Results of the PICO-SM Study

Autor: Kok Haw Jonathan Lim, Panagiotis Ntellas, Daniel Anderson, Lilly Simpson, Michael Braun, Marios Adamou, Jorge Barriuso, Katerina Dadouli, Jacqueline Connell, Joseph Williams, Theodora Germetaki, Deirdre Lehwald, Niall Fitzpatrick, Mark Cutting, Danielle McCool, Jurjees Hasan, Saifee Mullamitha, Kalena Marti, Mark Saunders, Konstantinos Kamposioras

Publikováno v: Cancers
Volume 15
Issue 4
Pages: 1226

The COVID-19 pandemic has resulted in unprecedented changes to the lives of patients with cancer. To evaluate the impact of the COVID-19 pandemic on the mental health and well-being of patients with colorectal cancer, we conducted a prospective longi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95570240458d0c3d0daffdccf7b36975

Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme

Autor: Kai-Keen Shiu, Clare Spooner, Saifee Mullamitha, Daniel Stevens, Angela M. Carter, Timothy Iveson

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
BMC Cancer

Background The standard first- and second- line chemotherapy backbone regimens for metastatic colorectal cancer (mCRC) are 5-fluorouracil (5-FU)/capecitabine-based with addition of irinotecan or oxaliplatin. Until recently, evidence for optimal seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692252b6550a6326ce0027527bc32045
https://doaj.org/article/229d9bcaf8e94a7ca6e073aab8cd592e

The Impact of Changes in Service Delivery in Patients With Colorectal Cancer During the Initial Phase of the COVID-19 Pandemic

Autor: Jacqueline Connell, Konstantinos Kamposioras, Jorge Barriuso, Michael Braun, Mark P Saunders, Daniel M. Anderson, Jurjees Hasan, Mark Cutting, Lilly Simpson, Kalena Marti, Danielle McCool, Saifee Mullamitha, Victoria Lavin, Kok Haw Jonathan Lim

Publikováno v: Clinical Colorectal Cancer
Kamposioras, K, Saunders, M, Lim, K H J, Marti, K, Anderson, D, Cutting, M, McCool, D, Connell, J, Thompson, L, Hasan, J, Braun, M, Lavin, V, Mullamitha, S & Barriuso, J 2020, ' The impact of changes in service delivery in patients with colorectal cancer during the initial phase of the COVID-19 pandemic ', Clinical Colorectal Cancer, vol. 0, 0, pp. 0 . https://doi.org/10.1016/j.clcc.2020.11.006

Background The COVID-19 pandemic has imposed significant changes in cancer service delivery resulting in increased anxiety and distress in both patients and clinicians. We aimed to investigate how these changes have been perceived by patients diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa4b62bdadd73721bfafe234bc97a20