Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Saif Shubber"'
Publikováno v:
Cavanagh, R, Shubber, S, Vllasaliu, D & Stolnik, S 2022, ' Enhanced permeation by amphiphilic surfactant is spatially heterogenous at membrane and cell level ', Journal of Controlled Release, vol. 345, pp. 734-743 . https://doi.org/10.1016/j.jconrel.2022.03.053
In the context of increased interest in permeability enhancement technologies to achieve mucosal delivery of drugs and biologics, we report our study on effects of the amphiphilic surfactant at cell membrane and cell population levels. Our results sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6c0b9edea4a683025686d60f5cc94a
https://pubmed.ncbi.nlm.nih.gov/35367276
https://pubmed.ncbi.nlm.nih.gov/35367276
Autor:
James Austerberry, Julia Morrison, Saif Shubber, Daniel Parreirinha, Hamzah Baig, Rubens Lima, Ian Fox, Katarzyna Wegner, Eoghan Molloy, Daniel Higazi
Publikováno v:
Toxicon. 214:S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53108a409fd43b7e635c4b5c9579ac41
https://doi.org/10.1016/j.toxicon.2021.11.020
https://doi.org/10.1016/j.toxicon.2021.11.020
Autor:
Vincent Martin, Mikhail Kalinichev, Andrew Splevins, Johannes Krupp, Philippe Picaut, Keith Foster, Jacquie Maignel, Elena Fonfria, Saif Shubber, Stéphane Lezmi
Publikováno v:
Toxins
Botulinum neurotoxin (BoNT) is a major therapeutic agent that is licensed in neurological indications, such as dystonia and spasticity. The BoNT family, which is produced in nature by clostridial bacteria, comprises several pharmacologically distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19dc3c90a257cb8243ba88b0b41ab7f
http://europepmc.org/articles/PMC5983264
http://europepmc.org/articles/PMC5983264
Publikováno v:
Pharmaceutical Research
Purpose CriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics. The intention of this study is to elucidate mechanism(s) responsibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff671f7c214c6a970d0025808cdd055
https://doi.org/10.1007/s11095-014-1481-5
https://doi.org/10.1007/s11095-014-1481-5
Autor:
Saif Shubber, Snow Stolnik, Martin C. Garnett, Driton Vllasaliu, Robyn Fowler, Cameron Alexander
Publikováno v:
Journal of Pharmaceutical Sciences. 102:114-125
Alkylglycoside surfactants have been proposed as drug delivery excipients with the potential to enhance mucosal drug absorption of therapeutic macromolecules. Previous work reported their drug absorption-promoting potential by demonstrating that seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ba05cb92c085f376a59abb8b8fc7be
https://doi.org/10.1002/jps.23340
https://doi.org/10.1002/jps.23340
Autor:
Christopher F. van der Walle, Elena Ambrosio, Sara Bersani, Shahid Uddin, Stefano Salmaso, Saif Shubber, Paolo Caliceti, Michela Barattin
Poly(ethylene glycol) (PEG) may be covalently conjugated to peptide drugs to overcome their rapid clearance but in doing so their potency can be lost. Here, a non-covalent approach was used to conjugate PEG bearing a terminal cholanic moiety (mPEG5kD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfa4e219590eaae6567eb3a62cdc50f
http://hdl.handle.net/11577/3181979
http://hdl.handle.net/11577/3181979
Autor:
Martin C. Garnett, Driton Vllasaliu, Snow Stolnik, Mike Eaton, Saif Shubber, Cameron Alexander
Publikováno v:
Biochemical and Biophysical Research Communications. 418:128-133
Extracellular calcium is crucial for functioning of the epithelial barrier. Compounds that bind calcium, reducing its extracellular levels, have therefore been investigated as mucosal absorption enhancers. However, the conditions under which calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59f60102aad28b007f090f242930e5a
https://doi.org/10.1016/j.bbrc.2011.12.146
https://doi.org/10.1016/j.bbrc.2011.12.146
Autor:
Dong Ki Lee, Sanyogitta Puri, G. Sebastiaan Winkler, Stephanie Allen, Saif Shubber, Giuseppe Mantovani, S. Sajeesh, Vanessa Loczenski Rose, Sebastian G. Spain
Publikováno v:
Biomacromolecules. 16(11)
Synthetic polymers containing quaternary phosphonium salts are an emerging class of materials for the delivery of oligo/polynucleotides. In this work, cationic phosphonium salt-containing polymethacrylates and their corresponding ammonium analogues w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9c610992c54680a28030340e8df968
https://pubmed.ncbi.nlm.nih.gov/26397811
https://pubmed.ncbi.nlm.nih.gov/26397811
Autor:
Monica Boita, Saif Shubber, Akira Shibuya, Didier G. Ebo, Vito Sabato, Franco H. Falcone, Luc S. De Clerck, Chris H. Bridts
Publikováno v:
The journal of allergy and clinical immunology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26973ff92664ef13096683f6cfd7f0b
http://hdl.handle.net/2318/1555012
http://hdl.handle.net/2318/1555012
Autor:
Vanessa Loczenski Rose, Saif Shubber, S. Sajeesh, Sebastian G. Spain, Sanyogitta Puri, Stephanie Allen, Dong-Ki Lee, G. Sebastiaan Winkler, Giuseppe Mantovani
Publikováno v:
Biomacromolecules; Nov2015, Vol. 16 Issue 11, p3480-3490, 11p