Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Saif Abdul-Majeed"'
Publikováno v:
Clinical pharmacokinetics. 58(2)
Proteasome inhibitors disrupt multiple pathways in cells and the bone marrow microenvironment, resulting in apoptosis and inhibition of cell-cycle progression, angiogenesis, and proliferation. Bortezomib is a first-in-class proteasome inhibitor appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff061c7f69b97e41181c0c8ed21de1a
https://pubmed.ncbi.nlm.nih.gov/29802543
https://pubmed.ncbi.nlm.nih.gov/29802543
Publikováno v:
Applied and Translational Genomics, Vol 5, Iss C, Pp 30-32 (2015)
Applied & Translational Genomics
Applied & Translational Genomics
Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer's disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by perma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32cc1639ccae22ab1598b677f1dbd93
https://doi.org/10.1016/j.atg.2015.05.004
https://doi.org/10.1016/j.atg.2015.05.004
Publikováno v:
Nutrients; Volume 9; Issue 2; Pages: 143
Nutrients, Vol 9, Iss 2, p 143 (2017)
Nutrients, 9(2):143
Nutrients
Nutrients, Vol 9, Iss 2, p 143 (2017)
Nutrients, 9(2):143
Nutrients
Both tocotrienol and statins are suppressors of the mevalonate pathway. Supplementation of tocotrienol among statin users could potentially protect them against osteoporosis. This study aimed to compare the effects of tocotrienol and lovastatin co-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689732ddf58dc0d3f0b1c426488305b3
https://doi.org/10.3390/nu9020143
https://doi.org/10.3390/nu9020143
Publikováno v:
Nutrients
Nutrients, Vol 6, Iss 11, Pp 4974-4983 (2014)
Volume 6
Issue 11
Pages 4974-4983
Nutrients, Vol 6, Iss 11, Pp 4974-4983 (2014)
Volume 6
Issue 11
Pages 4974-4983
This study aimed to evaluate the effects of annatto tocotrienol on indices of bone static histomorphometry in orchidectomized rats. Forty male rats were randomized into baseline (BL), sham (SH), orchidectomized (ORX), annatto tocotrienol-treated (AnT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f690edbed8596a6f1d4cde937e99120
https://pubmed.ncbi.nlm.nih.gov/25389899
https://pubmed.ncbi.nlm.nih.gov/25389899
Publikováno v:
Life sciences. 125
Aims Statins are competitive inhibitors of HMGCoA reductase and are commonly used as antihypercholesterolemic agents. Experimental studies clearly demonstrate the beneficial effects of statins on bone. Tocotrienols have also been shown to have anti-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29c31e4f3ce1611987f9393aee5825a
https://pubmed.ncbi.nlm.nih.gov/25534439
https://pubmed.ncbi.nlm.nih.gov/25534439
Publikováno v:
Current drug targets. 14(13)
Skeletal tissue undergoes continuous remodeling which makes it unique among other body tissues. Osteoporosis is a common bone metabolic disorder affecting both men and women. Osteoporosis and its complications mainly osteoporotic fractures, have a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfbaca9eb6416de02ac811725c6f1d6
https://pubmed.ncbi.nlm.nih.gov/23848479
https://pubmed.ncbi.nlm.nih.gov/23848479
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
Statins are HMGCoA reductase inhibitors and had been demonstrated to stimulate bone formation in rodents after high oral doses. Observational studies on patients treated with oral statins were varied. Delta-tocotrienol had been found to stimulate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c337f6bb2754fb05bfb56f35a616a5