Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Saien Lu"'
Publikováno v:
The Journal of Clinical Hypertension, Vol 26, Iss 3, Pp 274-285 (2024)
Abstract Electrocardiography (ECG) is an accessible diagnostic tool for screening patients with hypertensive left ventricular hypertrophy (LVH). However, its diagnostic sensitivity is low, with a high probability of false‐negatives. Thus, this stud
Externí odkaz:
https://doaj.org/article/977645414dd74bfbad67f441224cd64f
Autor:
Naijin Zhang, Ying Zhang, Yong Chen, Hao Qian, Boquan Wu, Saien Lu, Shilong You, Wancheng Xu, Yuanming Zou, Xinyue Huang, Wenbin Wang, Jingwei Liu, Da Li, Liu Cao, Yingxian Sun
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/7371460d3dba4275bb1ec3a36837470d
Autor:
Zeyu Yin, Shilong You, Shu Zhang, Linlin Zhang, Boquan Wu, Xinyue Huang, Saien Lu, Liu Cao, Ying Zhang, Da Li, Xingang Zhang, Jingwei Liu, Yingxian Sun, Naijin Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115228- (2023)
As a widely used lipid-lowering drug in clinical practice, atorvastatin is widely recognized for its role in protecting vascular endothelium in the cardiovascular system. However, a clear mechanistic understanding of its action is lacking. Here, we f
Externí odkaz:
https://doaj.org/article/44da3cdea1894968ae6e9b0918c6ec3a
Autor:
Xinxin Lu, Xinyue Huang, Haiqi Xu, Saien Lu, Shilong You, Jiaqi Xu, Qianru Zhan, Chao Dong, Ning Zhang, Ying Zhang, Liu Cao, Xingang Zhang, Naijin Zhang, Lijun Zhang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is involved in many biological processes by specifically binding
Externí odkaz:
https://doaj.org/article/ef17993e185a4dd7ad412c0d80ca9649
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Septin4, a protein localized at mitochondrion, can promote cells apoptosis mainly by binding XIAP (X-linked inhibitors of apoptosis), however, nothing is known about the role and mechanism of Septin4 in cardiomyocytes apoptosis. Here in the
Externí odkaz:
https://doaj.org/article/dac04999636d4cb782b846e6b79c64e0
Autor:
Xinxin Lu, Haiqi Xu, Jiaqi Xu, Saien Lu, Shilong You, Xinyue Huang, Naijin Zhang, Lijun Zhang
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and regulates different biological process. DNA damage response (DDR
Externí odkaz:
https://doaj.org/article/2d838963b20a4e918d205cb5c68a9226
Autor:
Naijin Zhang, Ying Zhang, Wei Miao, Chuning Shi, Zihan Chen, Boquan Wu, Yuanming Zou, Qiushi Ma, Shilong You, Saien Lu, Xinyue Huang, Jingwei Liu, Jiaqi Xu, Liu Cao, Yingxian Sun
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102238- (2022)
Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical roles in this process. Bcl-2-associated athanogene 3 (BAG3) is a molecular chaperone regulato
Externí odkaz:
https://doaj.org/article/cbbb039e0ae140de9747fdcd9e4bc534
Autor:
Naijin Zhang, Ying Zhang, Boquan Wu, Shaojun Wu, Shilong You, Saien Lu, Jingwei Liu, Xinyue Huang, Jiaqi Xu, Liu Cao, Yingxian Sun
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102141- (2021)
Poly(ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve clinical outcomes of cardiovascular disease, which suggests that the regulatory mechanism o
Externí odkaz:
https://doaj.org/article/a1c9e66200eb49a4af50bd127e625217
Autor:
Ying Zhang, Naijin Zhang, Yuanming Zou, Chunyu Song, Kexin Cao, Boquan Wu, Shilong You, Saien Lu, Dong Wang, Jiaqi Xu, Xinyue Huang, Pengyu Zhang, Zihao Fan, Jingwei Liu, Zhongyi Cheng, Zhe Zhang, Chuize Kong, Liu Cao, Yingxian Sun
Publikováno v:
Circulation Research. 132:601-624
Background: Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective t
Autor:
Lijun Zhang, Xinxin Lu, Xinyue Huang, Haiqi Xu, Saien Lu, Shilong You, jiaqi xu, Qianru Zhan, Chao Dong, Ning Zhang, Ying Zhang, Liu Cao, Naijin Zhang
Acute lymphoblastic leukemia (ALL) has been huge threaten for people health and finding effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is involved in many biological processes by specifically binding to substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba310e57d20fa74c23f072aecb19ab86
https://doi.org/10.21203/rs.3.rs-1811189/v1
https://doi.org/10.21203/rs.3.rs-1811189/v1