Memory CD8+T cells mediate early pathogen-specific protection via localized delivery of chemokines and IFNγ to clusters of monocytes

Autor: Marie Boutet, Erik Guillen, David R. Fooksman, Grégoire Lauvau, Fabien Delahaye, Zachary Benet, Saidi M.Homa Soudja, Caroline Koch

Publikováno v: Science Advances. 7

While cognate antigen drives clonal expansion of memory CD8+ T (CD8+ TM) cells to achieve sterilizing immunity in immunized hosts, not much is known on how cognate antigen contributes to early prot...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a07d06b7c4d0c2c6d8f577751aa973a9
https://doi.org/10.1126/sciadv.abf9975

The p60 and NamA autolysins fromListeria monocytogenescontribute to host colonization and induction of protective memory

Autor: Marilyn Gros, Aurel Frangaj, Brian Weinrick, Grégoire Lauvau, Massilva Rahmoun, William R. Jacobs, Ceena Chandrabos, Saidi M.Homa Soudja

Publikováno v: Cellular Microbiology. 17:147-163

Inducing long-term protective memory CD8+ T cells is a desirable goal for vaccines against intracellular pathogens. However, the mechanisms of differentiation of CD8+ T cells into long-lived memory cells capable of mediating protection of immunized h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3065182a6c89911c12fa9e5e98c0fb02
https://doi.org/10.1111/cmi.12362

Splenic CD8α+ dendritic cells undergo rapid programming by cytosolic bacteria and inflammation to induce protective CD8+ T-cell memory

Autor: Saidi M.Homa Soudja, Grégoire Lauvau, Laura Campisi, Nicolas Glaichenhaus, Frédéric Brau, Anne Lazzari, Frederic Geissmann, Emilie Narni-Mancinelli, Julie Cazareth, Delphine Bassand

Publikováno v: European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (6), pp.1594-605. ⟨10.1002/eji.201041036⟩

International audience; Memory CD8(+) T lymphocytes are critical effector cells of the adaptive immune system mediating long-lived pathogen-specific protective immunity. Three signals - antigen, costimulation and inflammation - orchestrate optimal CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8663a3fed5d777ad5b89e4e884bb0dcb
https://doi.org/10.1002/eji.201041036

Inflammatory monocytes activate memory CD8(+) T and innate NK lymphocytes independent of cognate antigen during microbial pathogen invasion

Autor: Anne Ruiz, Grégoire Lauvau, Saidi M.Homa Soudja, Julien C. Marie

Publikováno v: Immunity. 37(3)

Summary Memory CD8 + T cells induced upon immunization exhibit improved functional features that contribute to protection of immunized hosts. Although both cognate antigen recognition and inflammation are important for memory CD8 + T cell reactivatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234af18b8db2293fe2377aa5c4cea5f1
https://pubmed.ncbi.nlm.nih.gov/22999951

Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

Autor: Ernest Yakob, Grégoire Lauvau, Mike Veenstra, Deborah Palliser, Saidi M.Homa Soudja, Ceena Chandrabos

Publikováno v: Immunity. (6):974-988

Summary Cells of the innate immune system are essential for host defenses against primary microbial pathogen infections, yet their involvement in effective memory responses of vaccinated individuals has been poorly investigated. Here we show that mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4136cd87b593a218bd3dbf7c38d2e4