Výsledky vyhledávání - "Saida K. Bogus"

Akademický článek

2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1 H-indole hydrochloride (SS-68): Antiarrhythmic and cardioprotective activity and its molecular mechanisms of action (Part I)

Autor: Saida K. Bogus, Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Galina V. Sukoyan, Valery G. Abushkevich

Publikováno v: Research Results in Pharmacology, Vol 4, Iss 2, Pp 133-150 (2018)

Introduction. The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which compound 2-phenyl-1-(3-pyrrolidin-1

Externí odkaz: https://doaj.org/article/89b4724e6b224bbdb0442c3eed441901

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Akademický článek

Effects of new antiarrhythmic agent SS-68 on excitation conduction, electrical activity in Purkinje fibers and pulmonary veins: Assessment of safety and side effects risk

Autor: Saida K. Bogus, Vladislav S. Kuzmin, Denis V. Abramochkin, Konstantin F. Suzdalev, Pavel A. Galenko-Yaroshevsky

Publikováno v: Journal of Pharmacological Sciences, Vol 133, Iss 3, Pp 122-129 (2017)

The compound SS-68 has been selected among numerous new derivatives of indole and demonstrated antiarrhythmic effects in animal models. The present study concerns several aspects of SS-68 safety and efficacy as a potential antiarrhythmic drug. The fi

Externí odkaz: https://doaj.org/article/346d0749c0a745359a82c5ac833fcdc2

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Akademický článek

Effects of a new antiarrhythmic drug SS-68 on electrical activity in working atrial and ventricular myocardium of mouse and their ionic mechanisms

Autor: Saida K. Bogus, Denis V. Abramochkin, Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev

Publikováno v: Journal of Pharmacological Sciences, Vol 128, Iss 4, Pp 202-207 (2015)

SS-68 is a derivative of indole, which demonstrated strong antiarrhythmic effects not associated with significant QT prolongation in dog models of atrial fibrillation. Therefore, SS-68 was proposed as a new antiarrhythmic drug and the present study i

Externí odkaz: https://doaj.org/article/029c004062a3483c864031fda1b71f4f

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2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1H-indole hydrochloride (SS-68): Antiarrhythmic and Cardioprotective Activity and Its Molecular Mechanisms of Action (Part II)

Autor: Saida K. Bogus, Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Galina V. Sukoyan, Valery G. Abushkevich, Vladislav O. Soldatov

Publikováno v: Research Results in Pharmacology, Vol 4, Iss 3, Pp 73-86 (2018)
Research Results in Pharmacology 4(3): 73-86

Introduction. In previous studies on different animal models, it was shown that compound N-(N-butylpyrrolidine)-2-phenylindole hydrochloride (SS-68) has a broad antiarrhythmic activity. The molecular mechanisms of the pharmacological action of SS-68

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325f9a9b3c46eb0cdab32d5233aa5d09
https://rrpharmacology.pensoft.net/article/30329/download/pdf/

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Synthesis of Imidazo[1,2-a]Indoles from 2-Chloroindole-3-Carbaldehyde

Autor: Saida K. Bogus, Elena Yu. Shasheva, Kseniya A. Prikhodko, Natalia I. Vikrischuk, Pavel A. Galenko-Yaroshevsky, Sergey V. Kurbatov, Konstantin F. Suzdalev

Publikováno v: Chemistry of Heterocyclic Compounds. 52:303-308

A two-step approach towards the synthesis of imidazo[1,2-a]indoles from 2-chloroindole-3-carbaldehyde has been developed. It comprises the N-alkylation of indole ring by 2-bromo-1,1-diethoxyethane followed by a treatment with aromatic amine hydrochlo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33da9304fa98745dd08300d416060805
https://doi.org/10.1007/s10593-016-1882-y

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2-phenyl-1-(3-pyrrolidin-1-il-propyl)-1 H-indole hydrochloride (SS-68): Antiarrhythmic and cardioprotective activity and its molecular mechanisms of action (Part I)

Autor: Galina V. Sukoyan, Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Saida K. Bogus, Valery G. Abushkevich

Publikováno v: Research Results in Pharmacology 4(2): 133-150
Research Results in Pharmacology, Vol 4, Iss 2, Pp 133-150 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789d0f3361e7ebab907b218132f1bb3d
https://rrpharmacology.ru/article/28592/

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Effects of a new antiarrhythmic drug SS-68 on electrical activity in working atrial and ventricular myocardium of mouse and their ionic mechanisms

Autor: Denis V. Abramochkin, Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Saida K. Bogus

Publikováno v: Journal of Pharmacological Sciences, Vol 128, Iss 4, Pp 202-207 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749192aa2dea0a2a3997031fb74f95b0

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ChemInform Abstract: Synthesis of Imidazo[1,2-a]indoles (V) from 2-Chloroindole-3-carbaldehyde (I)

Autor: Elena Yu. Shasheva, Saida K. Bogus, Natalia I. Vikrischuk, Konstantin F. Suzdalev, Pavel A. Galenko-Yaroshevsky, Sergey V. Kurbatov, Kseniya A. Prikhodko

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93e3bc213e9c624a7609a20cdaeebd59
https://doi.org/10.1002/chin.201649136

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Effects of new antiarrhythmic agent SS-68 on excitation conduction, electrical activity in Purkinje fibers and pulmonary veins: Assessment of safety and side effects risk

Autor: Vladislav S. Kuzmin, Pavel A. Galenko-Yaroshevsky, Konstantin F. Suzdalev, Saida K. Bogus, Denis V. Abramochkin

Publikováno v: Journal of Pharmacological Sciences, Vol 133, Iss 3, Pp 122-129 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae0d65b843c4dbf7bd24131ac48db76
https://pubmed.ncbi.nlm.nih.gov/28325557

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