Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Said Zamani-Kord"'
Autor:
Paul D. Crowe, Said Zamani-Kord, Bin-Feng Li, Sam R. J. Hoare, Hua Wang, Charles Q. Huang, Siobhan Malany, Wilna J. Moree, Ajay Madan, Fabio C. Tucci, Graham Beaton, Chun Yang, Jianyun Wen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:947-951
Structure–activity relationship studies were conducted to reduce CYP2D6-mediated metabolism in a series of indene H1-antihistamines. Reductions in pKa via incorporation of a β-fluoro substituent or a heteroaryl moiety were shown to reduce contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8773da44cbab152060c581d4000c5d
https://doi.org/10.1016/j.bmcl.2010.12.053
https://doi.org/10.1016/j.bmcl.2010.12.053
Autor:
Charles Q. Huang, James R. McCarthy, Paul D. Crowe, Raymond S. Gross, John Saunders, Dimitri E. Grigoriadis, Jodene Nelson, Richard Lowe, Brian Dyck, John P. Williams, Dragan Marinkovic, Sam R. J. Hoare, Tim Coon, Robert W. Sullivan, Mustapha Haddach, Said Zamani-Kord, Manisha Moorjani, Zhiqiang Guo, Jane Han Bu, Takung Chen
Publikováno v:
Journal of Medicinal Chemistry. 48:5780-5793
Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochemical properties, new tricyclic CRF(1) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed6584cab9355c213297346348adfa0
https://doi.org/10.1021/jm049085v
https://doi.org/10.1021/jm049085v
Autor:
Said Zamani-Kord, Brian Dyck, Zhiqiang Guo, Robert W. Sullivan, Zhiyong Luo, Raymond S. Gross, Manisha Moorjani, Bin-Feng Li, Mustapha Haddach, John E. Tellew, Mehrak Kiankarimi, Marion Lanier, John P. Williams, James R. McCarthy, Dimitri Grigoriadis, Ta Kung Chen, Paul D. Crowe, John Saunders, Xiaohu Zhang, Jonathan Grey
Publikováno v:
Journal of Medicinal Chemistry. 48:5104-5107
The synthesis and SAR studies of tricyclic imidazo[4,5-b]pyridin-2-ones as human corticotropin-releasing factor receptor (CRF(1)) antagonists are discussed herein. Compound 16g was identified as a functional antagonist that inhibited CRF-stimulated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815355c45c4d5367cde1ab00c4dece95
https://doi.org/10.1021/jm050384+
https://doi.org/10.1021/jm050384+
Autor:
Sam R. J. Hoare, Graham Beaton, Bin-Feng Li, Paul D. Crowe, Said Zamani-Kord, Lisa M. Hernández, Wilna J. Moree, Charles Q. Huang, Jinghua Yu, Hua Wang, Siobhan Malany, Fabio C. Tucci, Chun Yang, Ajay Madan, Aida Sacaan, Robert E. Petroski, Jianyun Wen, Coon Timothy Richard, Margaret J. Bradbury, Kayvon Jalali, Dragan Marinkovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(19)
Analogs of the known H(1)-antihistamine R-dimethindene with suitable selectivity for key GPCRs, P450 enzymes and hERG channel were assessed for metabolism profile and in vivo properties. Several analogs were determined to exhibit diverse metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27771b1fadd5556d09bba470020874b2
https://pubmed.ncbi.nlm.nih.gov/20800486
https://pubmed.ncbi.nlm.nih.gov/20800486
Autor:
Paul D. Crowe, Chun Yang, Robert E. Petroski, Kayvon Jalali, Coon Timothy Richard, Wilna J. Moree, Sam R. J. Hoare, Bin-Feng Li, Said Zamani-Kord, Hua Wang, Graham Beaton, Siobhan Malany, Jianyun Wen, Ajay Madan, Jinghua Yu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
A series of indene analogs of the H1-antihistamine (−)-R-dimethindene was evaluated for selectivity in the search for potentially improved sedative-hypnotics. Variation of the 6-substitutent in the indene core in combination with a pendant electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be894ba9de790b30f323cfdd66230c69
https://pubmed.ncbi.nlm.nih.gov/20227880
https://pubmed.ncbi.nlm.nih.gov/20227880
Autor:
Fabio C. Tucci, Lisa M. Hernández, Graham Beaton, Ajay Madan, Bin-Feng Li, Margaret J. Bradbury, Robert E. Petroski, Wilna J. Moree, Hua Wang, Dragan Marinkovic, Jinghua Yu, Jianyun Wen, Raymond S. Gross, Siobhan Malany, Florence Jovic, Paul D. Crowe, Said Zamani-Kord, Coon Timothy Richard, Zhihong O’Brien, Aida Sacaan, Sam R. J. Hoare
Publikováno v:
Journal of medicinal chemistry. 52(17)
Analogues of the known H(1)-antihistamine R-dimethindene were profiled as potential agents for the treatment of insomnia. Several highly selective compounds were efficacious in rodent sleep models. On the basis of overall profile, indene 1d and benzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808d5f5aa83baab00ef217e473199e63
https://pubmed.ncbi.nlm.nih.gov/19663387
https://pubmed.ncbi.nlm.nih.gov/19663387
Autor:
Graham Beaton, Aixia Sun, Jason Haelewyn, Susan K. Sullivan, Wilna J. Moree, Michael P. Hedrick, Mark Santos, Margaret J. Bradbury, Jenny Wen, Jinghua Yu, Said Zamani-Kord, Coon Timothy Richard, Paul D. Crowe, Lisa M. Hernández, Siobhan Malany, Robert E. Petroski, Bin-Feng Li, Samuel J. Hoare
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
The benzimidazole core of the selective non-brain-penetrating H 1 -antihistamine mizolastine was used to identify a series of brain-penetrating H 1 -antihistamines for the potential treatment of insomnia. Using cassette PK studies, brain-penetrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66e9f7c78f6eb714a299f657f109cb6
https://pubmed.ncbi.nlm.nih.gov/19553115
https://pubmed.ncbi.nlm.nih.gov/19553115
Autor:
Wilna J. Moree, Bin-Feng Li, Florence Jovic, Timothy Coon, Jinghua Yu, Raymond S. Gross, Fabio Tucci, Dragan Marinkovic, Said Zamani-Kord, Siobhan Malany, Margaret J. Bradbury, Lisa M. Hernandez, Zhihong O’Brien, Jianyun Wen, Hua Wang, Samuel R. J. Hoare, Robert E. Petroski, Aida Sacaan, Ajay Madan, Paul D. Crowe
Publikováno v:
Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 17, p5307-5310, 4p