Zobrazeno 1 - 10
of 355
pro vyhledávání: '"Said M. Sebti"'
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106082- (2023)
Summary: KRAS mutations are prevalent in pancreatic and lung cancers, but not all mutant (mt) KRAS tumors are addicted to mt KRAS. Here, we discovered a 30-gene transcriptome signature “KDS30” that encodes a novel EGFR/ERBB2-driven signaling netw
Externí odkaz:
https://doaj.org/article/d36dcf12c3fb495b80f4008e28cd2572
Autor:
Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti, Mokenge P. Malafa
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects. Methods We report a novel function of VEDT
Externí odkaz:
https://doaj.org/article/4b1eb33314e540faa53a9f54910cd308
Autor:
Chunwei Cheng, Yan Liu, Maria E. Balasis, Thomas P. Garner, Jerry Li, Nicholas L. Simmons, Norbert Berndt, Hao Song, Lili Pan, Yong Qin, K. C. Nicolaou, Evripidis Gavathiotis, Said M. Sebti, Rongshi Li
Publikováno v:
Marine Drugs, Vol 12, Iss 8, Pp 4311-4325 (2014)
A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assay
Externí odkaz:
https://doaj.org/article/255b8c59125a43fea4568f61c9ee8827
Autor:
Chunwei Cheng, Yan Liu, Maria E. Balasis, Nicholas L. Simmons, Jerry Li, Hao Song, Lili Pan, Yong Qin, K. C. Nicolaou, Said M. Sebti, Rongshi Li
Publikováno v:
Marine Drugs, Vol 12, Iss 3, Pp 1335-1348 (2014)
A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Both atropisomers of mar
Externí odkaz:
https://doaj.org/article/3e3a58f6df074c149931498cfd008993
Autor:
Marco L. Davila, Said M. Sebti, Xuefeng Wang, Aslamuzzaman Kazi, Bin Yu, Bishwas Shrestha, Estelle V. Cervantes, Nolan J. Beatty, Kristen Spitler, Sae Bom Lee, Dylan Morrissey, Maria L. Cabral, Hiroshi Kotani, Gongbo Li, Justin C. Boucher
An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480f3f1f552353ae85ba30f8549f9333
https://doi.org/10.1158/2326-6066.c.6550362
https://doi.org/10.1158/2326-6066.c.6550362
Autor:
Marco L. Davila, Said M. Sebti, Xuefeng Wang, Aslamuzzaman Kazi, Bin Yu, Bishwas Shrestha, Estelle V. Cervantes, Nolan J. Beatty, Kristen Spitler, Sae Bom Lee, Dylan Morrissey, Maria L. Cabral, Hiroshi Kotani, Gongbo Li, Justin C. Boucher
Supplemental Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435c5667a376d910358801b37318b724
https://doi.org/10.1158/2326-6066.22543680.v1
https://doi.org/10.1158/2326-6066.22543680.v1
Autor:
Steven Grant, Said M. Sebti, Dipankar Bandyopadhyay, Jonathan Yu, Jewel Nkwocha, Kanika Sharma, Sri Lakshmi Chalasani, Xiaoyan Hu, Lin Li, Yanxia Ning, Yu Zhang, Xinyan Pei, Liang Zhou
Supplementary Data from Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05223bd2aac65f0051c418f502d65fe2
https://doi.org/10.1158/1541-7786.22527480
https://doi.org/10.1158/1541-7786.22527480
Autor:
Srikumar P. Chellappan, Barbara A. Centeno, Nicholas J. Lawrence, Said M. Sebti, Daniele Pernazza, Dongyu Zhang, Smitha Pillai, Sandeep Singh, Monika Verma, José G. Treviño
PDF file - 1279K, Supplementary Figure 1. PANC-1 and Mia-PaCa cells are highly sensitive to RRD-251. Supplementary Figure 2. RRD-251 enhances the pro-apoptotic effects of gemcitabine. TABLE 1. Varying sensitivity of pancreatic cancer cells to RRD-251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a6df2aab7e015427aac1a1837da16b
https://doi.org/10.1158/1535-7163.22498470.v1
https://doi.org/10.1158/1535-7163.22498470.v1
Autor:
Brian C. Betts, Said M. Sebti, Claudio Anasetti, Bruce R. Blazar, Harshani R. Lawrence, Nicholas J. Lawrence, Shernan G. Holtan, Elizabeth M. Sagatys, Michael L. Nieder, Marco L. Davila, Rawan G. Faramand, Lia Perez, Farhad Khimani, Taiga Nishihori, Nelli Bejanyan, Asmita Mishra, Jongphil Kim, Hany Elmariah, Kelly Walton, Joseph Pidala
Impact of JAK2/mTOR blockade on human NK cell function and proliferation. A) Graph shows the cytolytic activity ({plus minus}SEM) of NK cells after 4 hours of culture with K562 target cells, while exposed to DMSO, ruxolitinib (lμM), pacritinib (1.25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472281a0dfd04f48df3f41ca55b74674
https://doi.org/10.1158/1078-0432.22479069
https://doi.org/10.1158/1078-0432.22479069
Autor:
Brian C. Betts, Said M. Sebti, Claudio Anasetti, Bruce R. Blazar, Harshani R. Lawrence, Nicholas J. Lawrence, Shernan G. Holtan, Elizabeth M. Sagatys, Michael L. Nieder, Marco L. Davila, Rawan G. Faramand, Lia Perez, Farhad Khimani, Taiga Nishihori, Nelli Bejanyan, Asmita Mishra, Jongphil Kim, Hany Elmariah, Kelly Walton, Joseph Pidala
The table shows the pharmacokinetic analysis of pacritinib concentration over time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287a2018ed8b31a4ea62f70576bb4ae5
https://doi.org/10.1158/1078-0432.22479045.v1
https://doi.org/10.1158/1078-0432.22479045.v1