Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Said M. Afify"'
Autor:
Hideki Minematsu, Said M. Afify, Yuki Sugihara, Ghmkin Hassan, Maram H. Zahra, Akimasa Seno, Masaki Adachi, Masaharu Seno
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Previously, our group has demonstrated establishment of Cancer Stem Cell (CSC) models from stem cells in the presence of conditioned medium of cancer cell lines. In this study, we tried to identify the factors responsible for the induction o
Externí odkaz:
https://doaj.org/article/2dd3be2d767c48678d0e4eb56aa14b91
Autor:
Yanning Xu, Said M. Afify, Juan Du, Bingbing Liu, Ghmkin Hassan, Qing Wang, Hanbo Li, Yixin Liu, Xiaoying Fu, Zhengmao Zhu, Ling Chen, Masaharu Seno
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Cancer stem cells (CSCs) are capable of continuous proliferation, self-renewal and are proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer recurrence. We have established a model of CSCs that was originally
Externí odkaz:
https://doaj.org/article/2229408244c74020a7f0428b27bd490b
Autor:
Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra, Xiaoying Fu, Mohamad Al Kadi, Akimasa Seno, David S. Salomon, Masaharu Seno
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Cancer stem cells (CSCs) are generated under irregular microenvironment in vivo, of which mimic is quite difficult due to the lack of enough information of the factors responsible for cancer initiation. Here, we demonstrated that
Externí odkaz:
https://doaj.org/article/daf6adf4317e48ca892776e146be0047
Autor:
Kazuki Kumon, Said M. Afify, Ghmkin Hassan, Shunsuke Ueno, Sadia Monzur, Hend M. Nawara, Hagar A. Abu Quora, Mona Sheta, Yanning Xu, Xiaoying Fu, Maram H. Zahra, Akimasa Seno, Masaharu Seno
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Cancer stem cells (CSCs) are subpopulations in the malignant tumors that show self-renewal and multilineage differentiation into tumor microenvironment components that drive tumor growth and heterogeneity. In previous studies, our group succ
Externí odkaz:
https://doaj.org/article/94748b8e5a1d4c658dc75ade67ea7e3d
Autor:
Hager Mansour, Ph.D., Said M. Afify, Ph.D., Ghmkin Hassan, Ph.D., Hagar A. Abu Quora, Ph.D., Hend M. Nawara, Ph.D., Maram H. Zahra, Ph.D., Juan Du, Ph.D., Sadia Monzur, Ph.D., Toshiaki Ohara, M.D., Ph.D., Akimasa Seno, PhD, Masaharu Seno, Ph.D.
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 5, Iss , Pp 100062- (2022)
Metastasis is one of the major causes of cancer deaths. However, the mechanisms of cancer cells acquiring aggressiveness and metastatic potential are still under investigation. Although cancer stem cells (CSCs) have been suggested as tumor initiating
Externí odkaz:
https://doaj.org/article/ee1fe0fc410d44f9a94966074602ca1c
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 500 (2021)
Paclitaxel (PTX) is a chemotherapeutical agent commonly used to treat several kinds of cancer. PTX is known as a microtubule-targeting agent with a primary molecular mechanism that disrupts the dynamics of microtubules and induces mitotic arrest and
Externí odkaz:
https://doaj.org/article/904619f709ce416c99780c7a258f5689
Publikováno v:
Cancers, Vol 13, Iss 10, p 2491 (2021)
The immune system has been found to be suppressed in cancer patients. Cancer cells are extremely resistant to chemotherapeutic drugs, conventional immunotherapy, or cancer antigen vaccine therapy. Cancer immunotherapy, which is mainly based on immune
Externí odkaz:
https://doaj.org/article/a219504425d44f258528d57239addff0
Publikováno v:
Methods and Protocols, Vol 3, Iss 3, p 60 (2020)
Metastasis includes the dissemination of cancer cells from a malignant tumor and seed in distant sites inside the body forming secondary tumors. Metastatic cells from the primary tumor can move even before the cancer is detected. Therefore, metastase
Externí odkaz:
https://doaj.org/article/4d7ca540bb9e4fc18c4d9344d5db8f4d
Autor:
Hend M Nawara, Said M. Afify, Ghmkin Hassan, Maram H. Zahra, Marwa N Atallah, Hager Mansour, Hagar A. Abu Quora, Md Jahangir Alam, Amira Osman, Hiroki Kakuta, Hiroki Hamada, Akimasa Seno, Masaharu Seno
Publikováno v:
Cancers, Vol 12, Iss 6, p 1360 (2020)
“Combination therapy”, which is a treatment modality combining two or more therapeutic agents, is considered a cornerstone of cancer therapy. The combination of anticancer drugs, of which functions are different from the other, enhances the effic
Externí odkaz:
https://doaj.org/article/a353b86a051a47e1b2f4298e6127d3bb
Publikováno v:
Cancers, Vol 12, Iss 4, p 879 (2020)
The tumor microenvironment (TME) has an essential role in tumor initiation and development. Tumor cells are considered to actively create their microenvironment during tumorigenesis and tumor development. The TME contains multiple types of stromal ce
Externí odkaz:
https://doaj.org/article/db23f1b39da74188a9c90af8f3ef2341