Alternative Ligands at Melatonin Receptors

Autor: Céline, Legros, Said, Yous, Jean A, Boutin

Publikováno v: Methods in Molecular Biology
Methods in Molecular Biology, 2022, Methods in Molecular Biology, 2550, pp.151-162. ⟨10.1007/978-1-0716-2593-4_19⟩

International audience; Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a wide range of biological effects. Most of the main recognized effects of this hormone in mammals are due to its interaction with two G protein-coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5aae2b02af5e4597e79401d9fb14a78b
https://ut3-toulouseinp.hal.science/hal-04037116

Pictet–Spengler heterocyclizations via microwave-assisted degradation of DMSO

Autor: Basile Peres, Said Yous, Christophe Mesangeau, Daniel Lesieur, Thierry Besson

Publikováno v: Tetrahedron Letters. 46:2465-2468

For the first time the ability of DMSO to decompose rapidly under microwaves was explored in order to perform heterocyclizations in good conditions. This modified Pictet–Spengler reaction allowed, in this case, the synthesis of rigidified melatonin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a655250ea2604fa7b6917d6384769821
https://doi.org/10.1016/j.tetlet.2005.02.043

Three-Dimensional Quantitative Structure−Activity Relationships of Cyclo-oxygenase-2 (COX-2) Inhibitors: A Comparative Molecular Field Analysis

Autor: Daniel Lesieur, Nicolas Baurin, Said Yous, Philippe Chavatte, Christophe Marot

Publikováno v: Journal of Medicinal Chemistry. 44:3223-3230

The three-dimensional quantitative structure-activity relationship (3D-QSAR) approach using comparative molecular field analysis (CoMFA) was applied to an extensive series of 305 varied diarylheterocyclic derivatives known as COX-2 selective inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78af88e0d4b7940f71b75b6cf9e41a2e
https://doi.org/10.1021/jm0101343

Synthesis of 2(3H)-benzoxazolinone derivatives as potential beta-3-adrenergic receptor ligands

Autor: Daniel Lesieur, Said Yous, P. Depreux, J. F. Delhomel

Publikováno v: Scopus-Elsevier

Beta-3-subtype-adrenoceptors mediate lipolysis and in the search for potential beta-3-adrenergic receptor agonists for the treatment of obesity, we designed new arylethanolamines, structures B1 and B2, derived from 2(3H)-benzoxazolinone. To obtain th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc1bb1fa339083d8977c783ae058b5e
https://doi.org/10.1002/jhet.5570360521

ChemInform Abstract: Synthesis of 2(3H)-Benzoxazolinone Derivatives as Potential Melatonin Receptor Ligands

Autor: Said Yous, Frederique Klupsch, Isabelle Lesieur

Publikováno v: ChemInform. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3666e67db929fe0f0f35d802d9e13e6
https://doi.org/10.1002/chin.200127124