Výsledky vyhledávání - "Saibal K. Biswas"

Pharmacological and Dietary Antioxidant Therapies for Chronic Obstructive Pulmonary Disease

Autor: Saibal K. Biswas, Paul Kirkham, Irfan Rahman, J. W. Hwang

Publikováno v: Current Medicinal Chemistry. 20:1496-1530

The progression and exacerbations of chronic obstructive pulmonary disease (COPD) are intimately associated with tobacco smoke/biomass fuel-induced oxidative and aldehyde/carbonyl stress. Alterations in redox signaling proinflammatory kinases and tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befc94d01e73f95201bd532267dcc1dd
https://doi.org/10.2174/0929867311320120004

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Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

Autor: Probir Chakravarty, Paul Kirkham, Irfan Rahman, Gillian Spooner, David Adenuga, Ian L. Megson, Isaac K. Sundar, Danielle Fletcher, Saravanan Rajendrasozhan, Paul A. Whittaker, Koremu Meja, John A. Marwick, Saibal K. Biswas

Publikováno v: Meja, K K, Rajendrasozhan, S, Adenuga, D, Biswas, S K, Sundar, I K, Spooner, G, Marwick, J A, Chakravarty, P, Fletcher, D, Whittaker, P, Megson, I L, Kirkham, P A & Rahman, I 2008, ' Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2 ', American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 3, pp. 312-23 . https://doi.org/10.1165/rcmb.2008-0012OC

Oxidative stress as a result of cigarette smoking is an important etiologic factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), a chronic steroid-insensitive inflammatory disease of the airways. Histone deacetylase-2 (HDAC2),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dc43db1869940f8fef1acb04ccfb51
https://doi.org/10.1165/rcmb.2008-0012oc

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Modulation of steroid activity in chronic inflammation: A novel anti-inflammatory role for curcumin

Autor: Irfan Rahman, Saibal K. Biswas

Publikováno v: Molecular Nutrition & Food Research. 52:987-994

The expression of NF-kappaB (NF-kappaB)-dependent pro-inflammatory genes in response to oxidative stress is regulated by the acetylation-deacetylation status of histones bound to the DNA. It has been suggested that in severe asthma and in chronic obs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bf25d22d88983e36d69247ff13d27
https://doi.org/10.1002/mnfr.200700259

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Regulation of inflammation and redox signaling by dietary polyphenols

Autor: Paul Kirkham, Saibal K. Biswas, Irfan Rahman

Publikováno v: Biochemical Pharmacology. 72:1439-1452

Reactive oxygen species (ROS) play a key role in enhancing the inflammation through the activation of NF-kappaB and AP-1 transcription factors, and nuclear histone acetylation and deacetylation in various inflammatory diseases. Such undesired effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5a8a52525a362aa9540ec061d20439
https://doi.org/10.1016/j.bcp.2006.07.004

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Oxidant and antioxidant balance in the airways and airway diseases

Autor: Aruna Kode, Irfan Rahman, Saibal K. Biswas

Publikováno v: European Journal of Pharmacology. 533:222-239

Although oxygen is a prerequisite to life, at concentrations beyond the physiological limits it may be hazardous to the cells. Since the lungs are directly exposed to very high amounts of oxygen, it is imperative for the organ to possess defences aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39407c061804e6aabb1ca191be5e91d1
https://doi.org/10.1016/j.ejphar.2005.12.087

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Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E−/− mice

Autor: David E. Newby, Saibal K. Biswas, Ian L. Megson, Irfan Rahman

Publikováno v: Biochemical and Biophysical Research Communications. 338:1368-1373

Glutathione is a vital intracellular antioxidant. The enzymes involved in its synthesis and utilisation are tightly regulated, but the importance of glutathione regulation in atherogenesis is poorly understood. Here, we establish that glutathione is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3383fd330a5b6869089ccc2c1c41b691
https://doi.org/10.1016/j.bbrc.2005.10.098

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Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices

Autor: Manohar G Muddeshwar, Avinash K Rawal, Saibal K. Biswas

Publikováno v: Biochemical and Biophysical Research Communications. 324:588-596

The major damaging factor during and after the ischemic/hypoxic insult is the generation of free radicals, which leads to apoptosis, necrosis, and ultimately cell death. Rubia cordifolia (RC), Fagonia cretica linn (FC), and Tinospora cordifolia (TC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb20d3176263d539ebcbd57867b5c64b
https://doi.org/10.1016/j.bbrc.2004.09.094

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Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF‐κB activation and proinflammatory cytokine release in alveolar epithelial cells

Autor: Iain Kilty, Charlotte Anderson, Patryk Szulakowski, Saibal K. Biswas, Fiona M. Moodie, John A. Marwick, Mark R. Bauter, Irfan Rahman

Publikováno v: The FASEB Journal. 18:1897-1899

Oxidative stress is implicated in lung inflammation due to its effect on proinflammatory gene transcription. Changes in gene transcription depend on chromatin remodeling and the relative activities of histone acetyltransferases (HATs) and histone dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becfab564c4a1a7ec9006e31f4230ad6
https://doi.org/10.1096/fj.04-1506fje

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Environmental toxicity, redox signaling and lung inflammation:the role of glutathione

Autor: Saibal K. Biswas, Irfan Rahman

Publikováno v: Biswas, S K & Rahman, I 2009, ' Environmental toxicity, redox signaling and lung inflammation : the role of glutathione ', Molecular Aspects of Medicine, vol. 30, no. 1-2, pp. 60-76 . https://doi.org/10.1016/j.mam.2008.07.001

Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719cfbfc6e93a7044ccec1a885b2f8e0
https://www.pure.ed.ac.uk/ws/files/16323428/Environmental_toxicity_redox_signaling_and_lung_inflammation.pdf

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