Zobrazeno 1 - 10 of 170 pro vyhledávání: '"Saiama N. Waqar"'
1
Akademický článek
Pre-radiotherapy ctDNA liquid biopsy for risk stratification of oligometastatic non-small cell lung cancer
Autor: Nicholas P. Semenkovich, Shahed N. Badiyan, Pamela P. Samson, Hayley B. Stowe, Yun E. Wang, Rachel Star, Siddhartha Devarakonda, Ramaswamy Govindan, Saiama N. Waqar, Clifford G. Robinson, Gregory Vlacich, Bruna Pellini, Aadel A. Chaudhuri
Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2023)
Abstract The optimal treatment paradigm for patients with oligometastatic non-small cell lung cancer (NSCLC) remains unclear. Some patients with oligometastatic disease experience prolonged remission after locally consolidative radiation therapy (RT)
Externí odkaz: https://doaj.org/article/a58b67760151450588de5ad5ca91d57a
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2
Akademický článek
A phase I/II study of rovalpituzumab tesirine in delta-like 3—expressing advanced solid tumors
Autor: Aaron S. Mansfield, David S. Hong, Christine L. Hann, Anna F. Farago, Himisha Beltran, Saiama N. Waqar, Andrew E. Hendifar, Lowell B. Anthony, Matthew H. Taylor, Alan H. Bryce, Scott T. Tagawa, Karl Lewis, Jiaxin Niu, Christine H. Chung, James M. Cleary, Michael Rossi, Carrianne Ludwig, Ricardo Valenzuela, Yan Luo, Rahul Aggarwal
Publikováno v: npj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
Abstract Delta-like protein 3 (DLL3) is highly expressed in solid tumors, including neuroendocrine carcinomas/neuroendocrine tumors (NEC/NET). Rovalpituzumab tesirine (Rova-T) is a DLL3-targeting antibody-drug conjugate. Patients with NECs and other
Externí odkaz: https://doaj.org/article/41cea5032a0d44ac9ceef9a9bed44b7a
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3
Akademický článek
Exploring the Feasibility of Utilizing Limited Gene Panel Circulating Tumor DNA Clearance as a Biomarker in Patients With Locally Advanced Non-Small Cell Lung Cancer
Autor: Brendan Knapp, Laura Mezquita, Siddhartha Devarakonda, Mihaela Aldea, Saiama N. Waqar, Kym Pepin, Jeffrey P. Ward, Angela Botticella, Karen Howarth, Charlene Knape, Clive Morris, Ramaswamy Govindan, Benjamin Besse, Daniel Morgensztern
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
IntroductionCirculating tumor DNA (ctDNA) testing may identify patients at high risk for recurrence following chemoradiation (CRT) for locally advanced non-small cell lung cancer (LA-NSCLC). We evaluated the feasibility of ctDNA testing on a readily
Externí odkaz: https://doaj.org/article/bdec53ddcf914269b586e80415fd720d
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4
Akademický článek
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
Autor: Alex H. Wagner, Siddhartha Devarakonda, Zachary L. Skidmore, Kilannin Krysiak, Avinash Ramu, Lee Trani, Jason Kunisaki, Ashiq Masood, Saiama N. Waqar, Nicholas C. Spies, Daniel Morgensztern, Jason Waligorski, Jennifer Ponce, Robert S. Fulton, Leonard B. Maggi, Jason D. Weber, Mark A. Watson, Christopher J. O’Conor, Jon H. Ritter, Rachelle R. Olsen, Haixia Cheng, Anandaroop Mukhopadhyay, Ismail Can, Melissa H. Cessna, Trudy G. Oliver, Elaine R. Mardis, Richard K. Wilson, Malachi Griffith, Obi L. Griffith, Ramaswamy Govindan
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that act
Externí odkaz: https://doaj.org/article/633460ab94c74c7ba9529694b90819e7
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