Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Sai-Sai Xie"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 118-128 (2020)
A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE. Am
Externí odkaz:
https://doaj.org/article/78887ec9017f43a28cdbf77e16762211
Autor:
Peng Liu, Maojun Cheng, Jie Guo, Duanyuan Cao, Jinchong Luo, Yang Wan, Yuanying Fang, Yi Jin, Sai-Sai Xie, Jing Liu
Publikováno v:
Bioorganicmedicinal chemistry. 78
Here, we have designed and synthesized a series of melatonin-alkylbenzylamine hybrids as multitarget agents for the treatment of Alzheimer's disease (AD). Most of them exhibited a potent multifunctional profile involving cholinesterase inhibition and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50df50a4ac77f0536b5d19d3cf428d3d
https://pubmed.ncbi.nlm.nih.gov/36580744
https://pubmed.ncbi.nlm.nih.gov/36580744
Autor:
Yi Jin, Xinshu Xie, Sai-Sai Xie, Chaojun Zheng, Shun Yuan, Changhua Zhang, Yongbing Sun, Rikang Wang, Huilan Li, Lang Zhang
Publikováno v:
Journal of Cellular and Molecular Medicine
Val‐Val‐Tyr‐Pro (VVYP) peptide is one of the main active components of Globin digest (GD). Our previous studies indicated that VVYP could protect against acetaminophen and carbon tetrachloride‐induced acute liver failure in mice and decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930df7ce40fe4afb4a1108bcad269cba
https://doi.org/10.1111/jcmm.16229
https://doi.org/10.1111/jcmm.16229
Autor:
Jie Guo, Airen Xu, Maojun Cheng, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Sai-Sai Xie, Jing Liu
Publikováno v:
Drug Design, Development and Therapy.
Jie Guo,1,* Airen Xu,2,* Maojun Cheng,1 Yang Wan,1 Rikang Wang,1 Yuanying Fang,1 Yi Jin,1 Sai-Sai Xie,1 Jing Liu3 1National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc07632cb1ec09ecdac1028bbd100e49
https://www.dovepress.com/design-synthesis-and-biological-evaluation-of-new-34-dihydro-21h-quino-peer-reviewed-fulltext-article-DDDT
https://www.dovepress.com/design-synthesis-and-biological-evaluation-of-new-34-dihydro-21h-quino-peer-reviewed-fulltext-article-DDDT
Autor:
Jie Guo, Maojun Cheng, Peng Liu, Duanyuan Cao, Jinchong Luo, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Zhipeng Zhang, Sai‐Sai Xie, Jing Liu
Publikováno v:
Chemistrybiodiversity. 19(8)
The fragments, 3,4-(methylenedioxy)cinnamic acid amide and dithiocarbamates, have received increasing attention because of their multiple pharmacological activities in recent years, especially in anti-tumor. We synthesized 17 novel 3,4-(methylenediox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea748729d430614e8452ddf51eaf33d8
https://pubmed.ncbi.nlm.nih.gov/35703003
https://pubmed.ncbi.nlm.nih.gov/35703003
Autor:
Jinhua Zhu, Rémy Campagne, Shuhui Huang, Valérie Alezra, Quan Wen, Yang Wan, Yuanying Fang, Yi Jin, Chengfei Hu, Sai-Sai Xie, Emeric Miclet
Publikováno v:
ChemMedChem. 16:368-376
Antimicrobial peptides (AMPs) are promising antibacterial agents often hindered by their undesired hemolytic activity. Inspired by gramicidin S (GS), a well-known cyclodecapeptide, we synthesized a panel of antibacterial cyclopeptidomimetics using β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a1edf77ec47c983f55b3e4ade8fd23
https://doi.org/10.1002/cmdc.202000568
https://doi.org/10.1002/cmdc.202000568
Autor:
Sai-Sai Xie, Ke Pan, Dan Xia, Ze-Hui Shi, Xin-Liu Zhu, Lu-Lu Wang, Guimin Chen, Zhong-Bo Zhou
Publikováno v:
Journal of Natural Products. 83:2831-2843
Eighteen new Lycopodium alkaloids, lycosquarrines A–R (1–18), and eight known alkaloids were isolated from the aerial parts of Phlegmariurus squarrosus. Compounds 1–5 and 19, identified from natura...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e712dc85638b3425a9268528268004c
https://doi.org/10.1021/acs.jnatprod.9b00815
https://doi.org/10.1021/acs.jnatprod.9b00815
Autor:
Yuanying Fang, Rong-Hua Liu, Yi Jin, Zunhua Yang, Sai-Sai Xie, Shaokun Zhang, Lijuan Xiong, Liangxing Tu, Yanhua Liu, Min Li
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 50-58 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
GPR119 is a promising target for discovery of anti-type 2 diabetes mellitus agents. We described the optimisation of a novel series of pyrimido[5,4-b][1,4]oxazine derivatives as GPR119 agonists. Most designed compounds exhibited good agonistic activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa087b6ca8ff05a7b522d4ed90d6812
https://doaj.org/article/a861d20cef9a48f7aa0624e740af1933
https://doaj.org/article/a861d20cef9a48f7aa0624e740af1933
Autor:
Jie, Guo, Maojun, Cheng, Peng, Liu, Duanyuan, Cao, Jinchong, Luo, Yang, Wan, Yuanying, Fang, Yi, Jin, Sai-Sai, Xie, Jing, Liu
Publikováno v:
European Journal of Medicinal Chemistry. 242:114630
Alzheimer's disease (AD) possessed intricate pathogenesis. Currently, multi-targeted drugs were considered to have the potential to against AD by simultaneously triggering molecules in functionally complementary pathways. Hence, a series of molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df445723545c135c5d4a086c4535c1
https://doi.org/10.1016/j.ejmech.2022.114630
https://doi.org/10.1016/j.ejmech.2022.114630
Autor:
Zhipeng Zhang, Maojun Cheng, Jie Guo, Yang Wan, Rikang Wang, Yuanying Fang, Yi Jin, Sai-Sai Xie, Jing Liu
Publikováno v:
Journal of Molecular Structure. 1254:132319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec3a8381554d39f5ddc695c9f10026af
https://doi.org/10.1016/j.molstruc.2021.132319
https://doi.org/10.1016/j.molstruc.2021.132319