Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sai-Qi Wang"'
Publikováno v:
Molecular Biomedicine, Vol 4, Iss 1, Pp 1-20 (2023)
Abstract The pharmaceutical industry had a glorious year in 2022, with a total of 37 new drugs including 20 new chemical entities (NCEs) and 17 new biological entities (NBEs) approved by the Food and Drug Administration (FDA). These drugs are mainly
Externí odkaz:
https://doaj.org/article/61d2bf552f0a42309d03f13c40532c38
Autor:
Hui-Hui Hu, Sai-Qi Wang, Hai-Li Shang, Hui-Fang Lv, Bei-Bei Chen, She-Gan Gao, Xiao-Bing Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression in various tumors and is associated with a poor prognosis. FAK activation promotes tumor growth, invasion, metastasis, and angiogenesis via both kinase-depend
Externí odkaz:
https://doaj.org/article/615cda06e85a453393d08772a042157e
Autor:
Sai-Qi Wang, Qiu-Xu Teng, Shuai Wang, Zi-Ning Lei, Hui-Hui Hu, Hui-Fang Lv, Bei-Bei Chen, Jian-Zheng Wang, Xiao-Jing Shi, Wei-Feng Xu, Hong-Min Liu, Xiao-Bing Chen, Zhe-Sheng Chen, Bin Yu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 8, Pp 3263-3280 (2022)
Multidrug resistance (MDR) is the main cause of clinical treatment failure and poor prognosis in cancer. Targeting P-glycoprotein (P-gp) has been regarded as an effective strategy to overcome MDR. In this work, we reported our preclinical studies of
Externí odkaz:
https://doaj.org/article/072a36093d8c4524b51043193e62d640
Autor:
Huichen Zhao, Huihui Hu, Beibei Chen, Weifeng Xu, Jing Zhao, Chen Huang, Yishu Xing, Huifang Lv, Caiyun Nie, Jianzheng Wang, Yunduan He, Sai-Qi Wang, Xiao-Bing Chen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Gastric cancer is the fifth most common cancer and the third most common cause of cancer death all over the world. E-cadherin encoded by human CDH1 gene plays important roles in tumorigenesis as well as in tumor progression, invasion and metastasis.
Externí odkaz:
https://doaj.org/article/42c6cdbe4dcc41e49c150a4aa156c9d6
Autor:
Beibei Chen, Sai-Qi Wang, Jinxi Huang, Weifeng Xu, Huifang Lv, Caiyun Nie, Jianzheng Wang, Huichen Zhao, Yingjun Liu, Jitian Li, Canrong Lu, Jianying Zhang, Xiao-Bing Chen
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. However, the role of Krm2 in gastric cancer is not clear. The aim of this study w
Externí odkaz:
https://doaj.org/article/ee92a682b52b466e912f778c3a289244
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Gastric cancer is the fifth most common malignant tumor and second leading cause of cancer-related deaths worldwide. With the improved understanding of gastric cancer, a subset of gastric cancer patients infected with Epstein–Barr virus (EBV) has b
Externí odkaz:
https://doaj.org/article/82e48d4e539c4357a9673afd4e082a4a
Autor:
Xing-Jie Dai, Shi-Kun Ji, Meng-Jie Fu, Gao-Zhi Liu, Hui-Min Liu, Shao-Peng Wang, Liang Shen, Ning Wang, Herdewijn, Piet, Yi-Chao Zheng, Sai-Qi Wang, Xiao-Bing Chen
Publikováno v:
Theranostics; 2024, Vol. 14 Issue 4, p1464-1499, 36p
Autor:
Bin Yu, Zhe-Sheng Chen, Hong-Min Liu, Zi-Ning Lei, Xiao-Bing Chen, Shuai Wang, Qiu-Xu Teng, Sai-Qi Wang
Publikováno v:
Journal of Medicinal Chemistry. 64:16187-16204
Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-a]pyrimidine derivative WS-898 as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2036a824b075a3885fca3868ceac9efc
https://doi.org/10.1021/acs.jmedchem.1c01498
https://doi.org/10.1021/acs.jmedchem.1c01498
Autor:
Xiao-Bing Chen, Sai-Qi Wang, Mengru Wang, Zi-Ning Lei, Hong-Min Liu, Xiao-Han Yuan, Linlin Yang, Shuai Wang, Bin Yu, Jun-Feng Huo, Qiu-Xu Teng, Zhe-Sheng Chen
Publikováno v:
Journal of Medicinal Chemistry. 63:15979-15996
ABCB1 is a promising therapeutic target for overcoming multidrug resistance (MDR). In this work, we reported the structure-based design of triazolo[1,5-a]pyrimidines as new ABCB1 modulators, of which WS-691 significantly increased sensitization of AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52744004bd34c03351cc74950586ae3
https://doi.org/10.1021/acs.jmedchem.0c01741
https://doi.org/10.1021/acs.jmedchem.0c01741
Autor:
Sai-Qi Wang, Xiaobing Chen, Liangyu Bie, Suxia Luo, Ping Guo, Xiao-Yu Lu, Yan Wei, Yu Mu, Dan Li
Publikováno v:
Current Cancer Drug Targets. 20:700-709
Background: HOTAIR, one of the most widely studied long non-coding RNAs in tumors, is closely related to tumor proliferation, migration, invasion and chemoresistance. Objective: Here, we studied the mechanism behind proliferation and chemoresistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c916a01ad7c1a0edd0b3f49b6e7d8d0
https://doi.org/10.2174/1568009620666200504114000
https://doi.org/10.2174/1568009620666200504114000