Výsledky vyhledávání - "Sai-Peng Sim"

Akademický článek

Higher prevalence of harbouring BCR::ABL1 in first-degree relatives of chronic myeloid leukaemia (CML) patients compared to normal population

Autor: Jew Win Kuan, Anselm Ting Su, Sai-Peng Sim, Siow Phing Tay

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Abstract Background The role of familial influence in chronic myeloid leukaemia (CML) occurrence is less defined. Previously, we conducted a study to determine the prevalence of harbouring BCR::ABL1 in our local adult normal population (designated as

Externí odkaz: https://doaj.org/article/23e1317e0c2c4f7ba979aa1873e6a4ed

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Akademický článek

Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells

Autor: Sang-Nee Tan, Sai-Peng Sim

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-27 (2019)

Abstract Background It has been found that chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC). CRS can be caused by gastro-oesophageal reflux (GOR) that may reach nasopharynx. The major component of refluxate

Externí odkaz: https://doaj.org/article/de29b7825be8484798a7f3f084d74031

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Akademický článek

Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma

Autor: Sang-Nee Tan, Sai-Peng Sim, Alan Soo-Beng Khoo

Publikováno v: Human Genomics, Vol 12, Iss 1, Pp 1-21 (2018)

Abstract Background The mechanism underlying chromosome rearrangement in nasopharyngeal carcinoma (NPC) remains elusive. It is known that most of the aetiological factors of NPC trigger oxidative stress. Oxidative stress is a potent apoptotic inducer

Externí odkaz: https://doaj.org/article/d16c553c48554608a7650d6728b62aa5

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Akademický článek

Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

Autor: Sang-Nee Tan, Sai-Peng Sim

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-18 (2018)

Abstract Background Chronic rhinosinusitis (CRS) increases the risk of developing nasopharyngeal carcinoma (NPC) while nasopharyngeal reflux is known to be one of the major aetiological factors of CRS. Bile acid (BA), the component of gastric duodena

Externí odkaz: https://doaj.org/article/137b730dc3364a4483de09a3be2eb12d

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