Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Sai Shi"'
Autor:
Chengyu Yin, Boyu Liu, Zishan Dong, Sai Shi, Chenxing Peng, Yushuang Pan, Xiaochen Bi, Huimin Nie, Yunwen Zhang, Yan Tai, Qimiao Hu, Xuan Wang, Xiaomei Shao, Hailong An, Jianqiao Fang, Chuan Wang, Boyi Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflamm
Externí odkaz:
https://doaj.org/article/31bca7caa8ac48fe8f413ea4b7820891
Autor:
Sen Ma, Sai Shi, Binghong Xu, Meijun Liu, Lei Xie, Yang Su, Jiachen Li, Qinqin Liang, Sheng Ye, Yaxin Wang
Publikováno v:
mSystems, Vol 9, Iss 1 (2024)
ABSTRACTDengue fever is a mosquito-borne tropical disease caused by the dengue virus (DENV). The replication of DENV relies on the processing of its genome-encoded polyprotein by both viral protease NS3 (NS3pro) and host proteases. However, the impac
Externí odkaz:
https://doaj.org/article/5500dc0f2d954662bd1faf9d36ed76d5
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by enterovirus (EV) infection. EV71 is one of the major pathogens causing hand, foot, and mouth disease and is more likely to cause exacerbation and death than other
Externí odkaz:
https://doaj.org/article/4d37aed05b5d47779038f7be36f4fd83
Autor:
Weijia Sun, Shuai Guo, Yuheng Li, JianWei Li, Caizhi Liu, Yafei Chen, Xuzhao Wang, Yingjun Tan, Hua Tian, Cheng Wang, Ruikai Du, Guohui Zhong, Sai Shi, Biao Ma, Chang Qu, Jingxuan Fu, Xiaoyan Jin, Dingsheng Zhao, Yong Zhan, Shukuan Ling, Hailong An, Yingxian Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
Externí odkaz:
https://doaj.org/article/ad9a828c99b74de39cdca2c41f2000f0
Autor:
Yongxue Zhang, Qi Miao, Sai Shi, Han Hao, Xinmeng Li, Zeyao Pu, Yakun Yang, Hailong An, Wei Zhang, Youzhen Kong, Xu Pang, Cunyang Gu, Nikita Gamper, Yi Wu, Hailin Zhang, Xiaona Du
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110625- (2022)
Summary: Protein disulfide isomerase (PDI) plays a key role in maintaining cellular homeostasis by mediating protein folding via catalyzing disulfide bond formation, breakage, and rearrangement in the endoplasmic reticulum. Increasing evidence sugges
Externí odkaz:
https://doaj.org/article/a474577a064a425d89b9b341b2ff4d46
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 714-722 (2020)
The calcium-activated chloride channel, also known as TMEM16A, shows both calcium and membrane potential dependent activation. The channel is expressed broadly and contributes to a variety of physiological processes, and it is expected to be a target
Externí odkaz:
https://doaj.org/article/88d65be3e8d54093bdf6d07f3e969996
Autor:
Shuai Guo, Xue Bai, Yufei Liu, Sai Shi, Xuzhao Wang, Yong Zhan, Xianjiang Kang, Yafei Chen, Hailong An
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed o
Externí odkaz:
https://doaj.org/article/0f7f245d387f4589a17b161eedf1e890
Autor:
Chaoqun Li, Sai Shi, Dong Gao, Boying Li, Guoqiang Song, Yafei Chen, Hailong An, Chengfen Xing
Publikováno v:
ACS Applied Materials & Interfaces. 14:31715-31726
The gated state of anion channels is involved in the regulation of proliferation and migration of tumors. Specific regulators are urgently needed for efficacious cancer ablation. For this purpose, it is essential to understand the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082e212f073fe35efb64781f94fdef8d
https://doi.org/10.1021/acsami.2c08503
https://doi.org/10.1021/acsami.2c08503
Publikováno v:
Biophysical Journal. 121:2671-2683
The homodimerization of CD44 plays a key role in an intercellular-to-extracellular signal transduction and tumor progression. Acylated modification and specific membrane environments have been reported to mediate translocation and oligomerization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeb3414acae413e562e82d73b0827f9
https://doi.org/10.1016/j.bpj.2022.06.021
https://doi.org/10.1016/j.bpj.2022.06.021
STING (stimulator of interferon genes) is a crucial protein in the innate immune system’s response to viral and bacterial infections. In this study, we investigated the mechanistic and energetic mechanism of the conformational transition process of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c322ff5b567ae71b23448141f8a4ec
https://doi.org/10.1101/2023.05.03.539334
https://doi.org/10.1101/2023.05.03.539334
