Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sai P. Pydi"'
Autor:
Taiki Okumura, Takefumi Kimura, Yuki Ichikawa, Takanobu Iwadare, Shun-ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Takuro Uchida, Sai P. Pydi, Naoki Tanaka, Takeji Umemura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Thrombospondin 2 (TSP2) plays a vital role in collagen/fibrin formation, bone growth, vascular density regulation, hemostasis, and cell adhesion. Close associations of serum TSP2 with histological severity in non-alcoholic fatty liver diseas
Externí odkaz:
https://doaj.org/article/efbf9c3f37394982aa014cb4798abd89
Autor:
Takanobu Iwadare, Takefumi Kimura, Naoki Tanaka, Tomoo Yamazaki, Shun-ichi Wakabayashi, Taiki Okumura, Hiroyuki Kobayashi, Yuki Yamashita, Sai P. Pydi, Tomoyuki Nakajima, Mai Iwaya, Ayumi Sugiura, Satoru Joshita, Takeshi Uehara, Takeji Umemura
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Among several secreted glycoproteins belonging to the thrombospondin family, thrombospondin 2 (TSP2) is involved in various functions, including collagen/fibrin formation. Liver/serum TSP2 levels have been correlated to liver fibrosis stage
Externí odkaz:
https://doaj.org/article/cbb74aa4f06742c78b5d032babd3d074
Autor:
Takefumi Kimura, Sai P. Pydi, Lei Wang, Dhanush Haspula, Yinghong Cui, Huiyan Lu, Gabriele M. König, Evi Kostenis, Gregory R. Steinberg, Oksana Gavrilova, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Obesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mi
Externí odkaz:
https://doaj.org/article/f0d1158d61ee4a5a901478e2a9b74e39
Autor:
Luiz F. Barella, Mario Rossi, Sai P. Pydi, Jaroslawna Meister, Shanu Jain, Yinghong Cui, Oksana Gavrilova, Gianluca Fulgenzi, Lino Tessarollo, Jürgen Wess
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
During insulin-resistance, the compensatory expansion of beta-cell mass is able to delay or the onset of overt type 2 diabetes. Here, the authors report that beta-arrestin-1, an intracellular protein known to regulate signalling through G protein-cou
Externí odkaz:
https://doaj.org/article/6495975e0d934f97876f1a64e6b60529
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/3c8bf0c0e19d40af93eb582d87932e87
Autor:
Lei Wang, Sai P. Pydi, Lu Zhu, Luiz F. Barella, Yinghong Cui, Oksana Gavrilova, Kendra K. Bence, Cecile Vernochet, Jürgen Wess
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Gs-coupled receptor signaling is well known to modulate adipocyte metabolism, but the role of Gi-coupled receptors in adipose tissue is less well understood. Here the authors show that signaling via Gi-type G proteins expressed by adipocytes is essen
Externí odkaz:
https://doaj.org/article/f883d39ac98a4be2a5e5616bc15a5843
Autor:
Lei Wang, Sai P. Pydi, Yinghong Cui, Lu Zhu, Jaroslawna Meister, Oksana Gavrilova, Rebecca Berdeaux, Jean-Philippe Fortin, Kendra K. Bence, Cecile Vernochet, Jürgen Wess
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp 83-91 (2019)
Objective: Given the worldwide epidemics of obesity and type 2 diabetes, novel antidiabetic and appetite-suppressing drugs are urgently needed. Adipocytes play a central role in the regulation of whole-body glucose and energy homeostasis. The goal of
Externí odkaz:
https://doaj.org/article/4872288f7b4f49a6bff9e4021976af84
Autor:
Sai P. Pydi, Shanu Jain, Wesley Tung, Yinghong Cui, Lu Zhu, Wataru Sakamoto, Shalini Jain, Brent S. Abel, Monica C. Skarulis, Jie Liu, Thanh Huynh, Karel Pacak, Marc G. Caron, Oksana Gavrilova, Toren Finkel, Jürgen Wess
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Beta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and
Externí odkaz:
https://doaj.org/article/db4766c456f2475085560b5fbc6645dc
Autor:
Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jürgen Wess, Kenneth A. Jacobson
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels contribute to peripheral insulin resistance, which can ultimately lead to the development of T2D. F
Externí odkaz:
https://doaj.org/article/415ac4152bc74c40af64da7ddcf8b9cd
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1445 (2020)
G protein-coupled receptors (GPCRs) are cell surface receptors that mediate the function of extracellular ligands. Understanding how GPCRs work at the molecular level has important therapeutic implications, as 30–40% of the drugs currently in clini
Externí odkaz:
https://doaj.org/article/46c7759ee7be4ec7bb9ca967ef9b962c