Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sai M. Pulukuri"'
Autor:
Keli Song, James Minissale, Richard A. Klinghoffer, James Garnsey, Katherine Galvin, Kristina Xega, Sai M Pulukuri, James M. Gavin, Xiaofeng Yang, Pooja Shah, Gary Shapiro, Cong Li, Vaishali Shinde, Eric S. Lightcap, Dennis Huszar, Zhen Lu, Stephen Grossman, Erik Koenig, Pengfei Yu, Steve Langston, Hisashi Imaichi, Serge Y. Fuchs, Mithun Khattar, Beryl A. Hatton, Yu Fu, Hongru Zhang, Dylan England, Michael Milhollen, Jessica Riceberg, Xingyue He
Publikováno v:
Sci Transl Med
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small molecule inhibitor of SUMOylation, pharmacologi
Autor:
Xingyue He, Jessica Riceberg, Sai M Pulukuri, Steve Grossman, Vaishali Shinde, Pooja Shah, James E Brownell, Larry Dick, John Newcomb, Neil Bence
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123882 (2015)
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates important cellular processes including chromosome structure, kinetochore function, chromosome segregation, nuclear and sub-nuclear organization, transcript
Externí odkaz:
https://doaj.org/article/13e1cfa28eb7421c9e7186a4338a176c
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Autor:
Misato Kaishima, Ryo Mizojiri, Michael G. Klein, Xingyue He, Yoichi Kawakita, Toshiya Tamura, Hironobu Maezaki, Moriteru Asano, Sai M Pulukuri, Ryo Dairiki, Shuichi Miyakawa, Yusuke Nakayama, Kozo Hayashi, Richard Tjhen, Kenichi Iwai, Kazuho Nishimura, Misa Iwatani, Maki Miyamoto, Gyorgy Snell, Masahiro Yaguchi, Yukiko Yamamoto, Daisuke Nakata, Toshiyuki Nomura, Wes Lane, Yoshiteru Ito, Mika Teratani
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp n/a-n/a (2018)
The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent inhibito
Autor:
John Newcomb, James M. Gavin, Nancy J. Bump, Stephen Tirrell, Lawrence R. Dick, Saurabh Menon, Jessica Huck, Petter Veiby, Benjamin S. Amidon, Yu Yang, Marc L. Hyer, Paul D. Greenspan, Fleming Paul E, Teresa A. Soucy, Jim Brownell, Michael Sintchak, Josh Powe, Steve Langston, Mark Manfredi, Judy Shi, Jeff Ciavarri, Darshan S. Sappal, Frank Bruzzese, Mike Kuranda, Katherine Galvin, Michael Milhollen, Ping Li, Neil F. Bence, Jing Tao Wu, Claudia Rabino, Chris Claiborne, Tary Traore, Jennifer Duffy, Jessica Riceberg, Robert J. Griffin, Kara Hoar, Anya Lublinsky, Bradley Stringer, Sai M Pulukuri
Publikováno v:
Nature medicine. 24(2)
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulator
Autor:
Sai M Pulukuri, James Minissale, Neil F. Bence, Matt Duffey, Hirotake Mizutani, He Xu, Hu Zhigen, Lawrence R. Dick, Xingyue He, Dylan England, Erik Koenig, Pooja Shah, Xiaofeng Yang, Hua Liao, Teresa A. Soucy, James E. Brownell, Melissa Gallery, Claudia Rabino, John Newcomb, Hugues Bernard, John Bradley, Jianping Guo, Mike Sintchak, Zhong-Hua Yan, Kristina Xega, Steve Langston, Ryan Chau, Jessica Riceberg, Eric S. Lightcap
Publikováno v:
Nature chemical biology. 13(11)
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-bas
Autor:
Vaishali Shinde, Steve Grossman, James E. Brownell, Neil F. Bence, Sai M Pulukuri, John Newcomb, Xingyue He, Jessica Riceberg, Larry Dick, Pooja Shah
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0123882 (2015)
PLoS ONE, Vol 10, Iss 4, p e0123882 (2015)
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates important cellular processes including chromosome structure, kinetochore function, chromosome segregation, nuclear and sub-nuclear organization, transcript
Autor:
Sai M Pulukuri, Eric S. Lightcap, Teresa A. Soucy, James E. Brownell, John Newcomb, Keli Song, Erik Koenig, Katherine Galvin, Anna Kreshock, Dylan England, Stephen Grossman, Steve Langston, Xingyue He, Hirotake Mizutani, Jessica Riceberg, Larry Dick
Publikováno v:
Cancer Research. 77:1147-1147
SUMOylation has been implicated in many cellular processes that are important for cancer cell survival, including cell cycle, chromosome structure and segregation, nuclear and subnuclear organization, transcription and DNA damage repair. However, a p
Autor:
Patrick Conley, Sai M Pulukuri, Peixuan Guo, Prithviraj Patankar, Songchuan Guo, Sherine Abdelmawla, Qi-Xiang Li, Joseph Trebley, Limin Zhang
Previous studies have shown that the packaging RNA (pRNA) of bacteriophage phi29 DNA packaging motor folds into a compact structure, constituting a RNA nanoparticle that can be modularized with functional groups as a nanodelivery system. pRNA nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1fd3def5a2d12a1c24af432cdf8a44
https://europepmc.org/articles/PMC3129564/
https://europepmc.org/articles/PMC3129564/
Autor:
Paul E. Fleming, James M. Gavin, Yu Yang, Marc Hyer, Petter Veiby, Michael Milhollen, Peter G. Smith, Tary Traore, Sai M. Pulukuri, Jeff Ciavarri, Mark Manfredi, Darshan S. Sappal, Neil Bence, James E. Brownell, Kara Hoar, Jessica Huck, Christopher F. Claiborne, Lawrence Dick, Derek Liqiang Tou
Publikováno v:
Molecular Cancer Therapeutics. 10:C82-C82
Millennium Pharmaceuticals, Inc. is dedicated to the discovery and development of novel oncology therapeutics in the area of protein homeostasis. Here we report the identification and characterization of compounds that target the ubiquitin activating