Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sai Kumar Chakka"'
Autor:
Loes M. Stevers, Madita Wolter, Graeme W. Carlile, Dwight Macdonald, Luc Richard, Frank Gielkens, John W. Hanrahan, David Y. Thomas, Sai Kumar Chakka, Mark L. Peterson, Helmut Thomas, Luc Brunsveld, Christian Ottmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Mutations in the chloride channel CFTR that impair plasma membrane insertion and ion transport are the cause of cystic fibrosis. Here, the authors identify a macrocycle that stabilizes the interaction of mutant CFTR with the chaperone-like protein 14
Externí odkaz:
https://doaj.org/article/92fd952667d14a1ba9705d63a6a37de1
Autor:
Sai Kumar Chakka, Oluseye K. Onajole, Thavendran Govender, Glenn E. M. Maguire, Hong Su, Hendrik G. Kruger
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 8, Pp o1901-o1902 (2010)
The structure of the title compound, C13H14O2, a pentacycloundecane cage derivative, exhibits unusual Csp3—Csp3 single-bond lengths ranging from 1.505 (3) to 1.607 (2) Å and strained bond angles as small as 88.7 (1)° and as large as 121.0 (2)°.
Externí odkaz:
https://doaj.org/article/6e7aaa1525804cf4a4a3a2cfde61d6b4
Autor:
Kristopher Josephson, Anthony Silvestri, Jennifer L. Fribourgh, Walter M. Bray, Brian David, Cameron C. Hanna, Sai Kumar Chakka, Alex Hyatt, Monique Porcella, Dio Dieppa-Matos, Cameron R. Pye, Joshua Schwochert
Publikováno v:
Molecular Cancer Research. 21:B018-B018
While there has been tremendous progress developing small molecule covalent K-Ras G12C inhibitors that bind Ras-off (GDP) and inhibit nucleotide exchange, there remains a need for additional K-Ras inhibitors with different Ras isoform/mutant selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60b4591ed5f4291b92a8e807a847dd4c
https://doi.org/10.1158/1557-3125.ras23-b018
https://doi.org/10.1158/1557-3125.ras23-b018
Autor:
Angelica M. Bello, Amit Sarswat, Andrew V. Caprariello, Chithra M. Muthuramu, Lakshmi P. Kotra, Sai Kumar Chakka, Ewa Wasilewski, Shannon E. Dunn, Peter K. Stys
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2643-2656
Protein arginine deiminases (PAD) are implicated in a variety of inflammatory and neurodegenerative diseases including multiple sclerosis (MS). Following the discovery of an in silico hit containing hydantoin and a piperidine moiety, we hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956c87f1213d1dffc54c5b327fc1a494
https://doi.org/10.1016/j.bmc.2017.03.006
https://doi.org/10.1016/j.bmc.2017.03.006
Autor:
Angelica M. Bello, Mohd Asad, Sourabh Mundra, Sumit Rathore, Radhakrishnan Mahesh, Lakshmi P. Kotra, Pawan Malhotra, Jane Yang, Lianhu Wei, Asif Mohmmed, Sai Kumar Chakka, Vandana Thakur
Publikováno v:
Bioorganicmedicinal chemistry. 25(20)
The prokaryotic ATP-dependent ClpP protease, localized in the relict plastid of malaria parasite, represents a potential drug target. In the present study, we utilized in silico structure-based screening and medicinal chemistry approaches to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e6e265f8ee42ef876f2c55213d1473
https://pubmed.ncbi.nlm.nih.gov/28917450
https://pubmed.ncbi.nlm.nih.gov/28917450
Autor:
Sai Kumar Chakka, Yulia Katsman, Noruê Salum, Angelica M. Bello, Iain Scovell, Madeleine C. Bareau, Donald R. Branch, Anton Neschadim, Lakshmi P. Kotra, Meena K. Purohit
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2739-2752
Idiopathic or immune thrombocytopenia (ITP) is a serious clinical disorder involving the destruction of platelets by macrophages. Small molecule therapeutics are highly sought after to ease the burden on current therapies derived from human sources.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80802e9f45f15f10b79dc45d50509b92
https://doi.org/10.1016/j.bmc.2014.03.016
https://doi.org/10.1016/j.bmc.2014.03.016
Autor:
Serge Zaretsky, Conor C. G. Scully, Megan A. St. Denis, Andrew L. Roughton, Andrei K. Yudin, Jennifer L. Hickey, M. Monzur Morshed, Sai Kumar Chakka
Publikováno v:
Journal of medicinal chemistry. 59(11)
We have developed a strategy for synthesizing passively permeable peptidomimetic macrocycles. The cyclization chemistry centers on using aziridine aldehydes in a multicomponent reaction with peptides and isocyanides. The linker region in the resultin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b0e7a1bb4b1e1f7b5f21beeab8c7d9
https://pubmed.ncbi.nlm.nih.gov/27120576
https://pubmed.ncbi.nlm.nih.gov/27120576
Autor:
Sphelele C. Sosibo, Vivian Francis, Thavendran Govender, Zamani E. D. Cele, Hendrik G. Kruger, Glenn E. M. Maguire, Per I. Arvidsson, Sai Kumar Chakka
Publikováno v:
Tetrahedron: Asymmetry. 23:616-622
A series of novel TIQ based N,N′-oxide ligands were synthesised and screened for their catalytic activity in the enantioselective conjugate addition of thioglycolate to chalcones. Bulky groups on the side chain of the TIQ backbone provided the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc9a6792e881cde54ba345e5b796770a
https://doi.org/10.1016/j.tetasy.2012.04.010
https://doi.org/10.1016/j.tetasy.2012.04.010
Autor:
Hendrik G. Kruger, Pher G. Andersson, Glenn E. M. Maguire, Byron K. Peters, Thavendran Govender, Sai Kumar Chakka
Publikováno v:
Tetrahedron: Asymmetry. 21:2295-2301
A novel family of tetrahydroisoquinoline (TIQ) phosphine–oxazoline ligands and four corresponding iridium complexes have been developed and applied to the asymmetric hydrogenation of unfunctionalized olefins. The results showed that the best conver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1b8c3534c5c23d8b89671cfff81ab39
https://doi.org/10.1016/j.tetasy.2010.07.032
https://doi.org/10.1016/j.tetasy.2010.07.032
Autor:
Glenn E. M. Maguire, Byron K. Peters, Sai Kumar Chakka, Tricia Naicker, Hendrik G. Kruger, Pher G. Andersson, Thavendran Govender
Publikováno v:
Tetrahedron: Asymmetry. 21:679-687
The use of the tetrahydroisoquinoline scaffold is well documented in biologically active compounds. However, reports of the utilisation of tetrahydroisoquinoline compounds in asymmetric catalysis a ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67631fb39dcb0754525d869ee5a2be53
https://doi.org/10.1016/j.tetasy.2010.04.017
https://doi.org/10.1016/j.tetasy.2010.04.017