Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sai Kiran Sharma"'
Autor:
Patrícia M. R. Pereira, Sai Kiran Sharma, Lukas M. Carter, Kimberly J. Edwards, Jacob Pourat, Ashwin Ragupathi, Yelena Y. Janjigian, Jeremy C. Durack, Jason S. Lewis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Trastuzumab binding to tumor cells depends on the availability of HER2 at the cell membrane. Here the authors show that caveolin-1 (CAV1) regulates HER2 density at the cell membranes and that CAV1 gene knockdown or protein depletion via the cholester
Externí odkaz:
https://doaj.org/article/655bc247cda34be5801b730bd0910363
Autor:
Michael R. McDevitt, Daniel L. J. Thorek, Takeshi Hashimoto, Tatsuo Gondo, Darren R. Veach, Sai Kiran Sharma, Teja Muralidhar Kalidindi, Diane S. Abou, Philip A. Watson, Bradley J. Beattie, Oskar Vilhemsson Timmermand, Sven-Erik Strand, Jason S. Lewis, Peter T. Scardino, Howard I. Scher, Hans Lilja, Steven M. Larson, David Ulmert
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream
Externí odkaz:
https://doaj.org/article/02a356c6cc14425c8da1a1e7764743bc
Autor:
Jason S. Lewis, Charles M. Rudin, John T. Poirier, Nagavarakishore Pillarsetty, Triparna Sen, William D. Travis, Alessandra Piersigilli, Avelyn Mae Delos Reyes, Joshua A. Korsen, Komal Mandleywala, Zachary V. Samuels, Sai Kiran Sharma, Lukas M. Carter, Salomon Tendler, Kathryn M. Tully
Supplementary Figure from Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d287ee932905c9f73acd65d57e15e2
https://doi.org/10.1158/1078-0432.22483574
https://doi.org/10.1158/1078-0432.22483574
Autor:
Jason S. Lewis, John T. Poirier, Scott J. Dylla, Charles M. Rudin, Brian M. Zeglis, David Liu, Vikram Sisodiya, Viola Allaj, Eric B. Johansen, Kristen M. Cunanan, Joseph Sandoval, Sheila Bheddah, Kumiko Isse, Omar Hamdy, Eric E. Gardner, Alexander J. Bankovich, Alessandra Piersigilli, Sean D. Carlin, Dalya Abdel-Atti, Jacob Pourat, Sai Kiran Sharma
Supplemental data detailing the methods and results for the synthesis and in vitro characterization of the radioimmunoconjugates, longitudinal PET imaging and ex vivo analyses in various models described within the main text.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f94bdb09e5ffcd3243607bd018f429
https://doi.org/10.1158/0008-5472.22414472.v1
https://doi.org/10.1158/0008-5472.22414472.v1
Autor:
David Ulmert, Michael R. McDevitt, Steven M. Larson, Hans G. Lilja, Diane S. Abou, Jason S. Lewis, Sai Kiran Sharma, Sven-Erik Strand, Dipti Metha, Philip A. Watson, Darren Veach, Nicholas Mitsiades, Anson T. Ku, Daniel L.J. Thorek
Purpose:The impact of androgen receptor (AR) activity in breast cancer biology is unclear. We characterized and tested a novel therapy to an AR-governed target in breast cancer.Experimental Design: We evaluated the expression of prototypical AR gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0565406add7f006b2b6ba190eb688bfa
https://doi.org/10.1158/1078-0432.c.6528689.v1
https://doi.org/10.1158/1078-0432.c.6528689.v1
Autor:
Jason S. Lewis, Charles M. Rudin, John T. Poirier, Nagavarakishore Pillarsetty, Triparna Sen, William D. Travis, Alessandra Piersigilli, Avelyn Mae Delos Reyes, Joshua A. Korsen, Komal Mandleywala, Zachary V. Samuels, Sai Kiran Sharma, Lukas M. Carter, Salomon Tendler, Kathryn M. Tully
Supplementary Data from Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de601a14384c3143c8705e31f669435
https://doi.org/10.1158/1078-0432.22483580.v1
https://doi.org/10.1158/1078-0432.22483580.v1
Autor:
Jason S. Lewis, John T. Poirier, Scott J. Dylla, Charles M. Rudin, Brian M. Zeglis, David Liu, Vikram Sisodiya, Viola Allaj, Eric B. Johansen, Kristen M. Cunanan, Joseph Sandoval, Sheila Bheddah, Kumiko Isse, Omar Hamdy, Eric E. Gardner, Alexander J. Bankovich, Alessandra Piersigilli, Sean D. Carlin, Dalya Abdel-Atti, Jacob Pourat, Sai Kiran Sharma
The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell lung cancer (SCLC) and high-grade neuroendocrine carcinomas. Rovalpituzumab teserine (Rova-T; SC16LD6.5) is a first-in-class DLL3-targeted antibody–drug conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e248ab8a2a739fa603425a017db548
https://doi.org/10.1158/0008-5472.c.6508991.v1
https://doi.org/10.1158/0008-5472.c.6508991.v1
Autor:
Brian M. Zeglis, Jason S. Lewis, Prakash Radhakrishnan, Michael A. Hollingsworth, Madi R. Madiyalakan, Elisa de Stanchina, Cory L. Brooks, Brandy White, Huiyong Zhao, Maria S. Jiao, Outi Keinänen, Kimberly J. Edwards, Jacob Pourat, Alessandra Piersigilli, Kyeara N. Mack, Sai Kiran Sharma
Supplementary Figure from ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e9857cedc774d1cc1d3409ad0bd306
https://doi.org/10.1158/1078-0432.22484397
https://doi.org/10.1158/1078-0432.22484397
Autor:
Jason S. Lewis, Charles M. Rudin, John T. Poirier, Nagavarakishore Pillarsetty, Triparna Sen, William D. Travis, Alessandra Piersigilli, Avelyn Mae Delos Reyes, Joshua A. Korsen, Komal Mandleywala, Zachary V. Samuels, Sai Kiran Sharma, Lukas M. Carter, Salomon Tendler, Kathryn M. Tully
Purpose:Small cell lung cancer (SCLC) is an exceptionally lethal form of lung cancer with limited treatment options. Delta-like ligand 3 (DLL3) is an attractive therapeutic target as surface expression is almost exclusive to tumor cells.Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f434032382cffa213eacf1d20935fda
https://doi.org/10.1158/1078-0432.c.6531161
https://doi.org/10.1158/1078-0432.c.6531161
Autor:
Brian M. Zeglis, Jason S. Lewis, Prakash Radhakrishnan, Michael A. Hollingsworth, Madi R. Madiyalakan, Elisa de Stanchina, Cory L. Brooks, Brandy White, Huiyong Zhao, Maria S. Jiao, Outi Keinänen, Kimberly J. Edwards, Jacob Pourat, Alessandra Piersigilli, Kyeara N. Mack, Sai Kiran Sharma
Supplementary Date from ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770ff576373df973b27a901613efff34
https://doi.org/10.1158/1078-0432.22484403
https://doi.org/10.1158/1078-0432.22484403