Výsledky vyhledávání - "Sai K. Buddai"

An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase

Autor: Genmin Lu, Sriram Krishnaswamy, Sai K. Buddai, Juliana M. Layzer, Christopher P. Rusconi, Dougald M. Monroe, Bruce A. Sullenger

The interaction of factor Xa with factor Va on membranes to form prothrombinase profoundly increases the rate of the proteolytic conversion of prothrombin to thrombin. We present the characterization of an RNA aptamer (RNA(11F7t)) selected from a com

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Nematode anticoagulant protein c2 reveals a site on factor Xa that is important for macromolecular substrate binding to human prothrombinase

Autor: Peter W. Bergum, George P. Vlasuk, Sriram Krishnaswamy, Sai K. Buddai, Larisa Toulokhonova

Publikováno v: The Journal of biological chemistry. 277(29)

The binding of recombinant nematode anticoagulant protein c2 (NAPc2) to either factor X or Xa is a requisite step in the pathway for the potent inhibition of VIIa tissue factor. We have used NAPc2 as a tight binding probe of human Xa to investigate p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5a392263cdb502d190b4d624af9588
https://pubmed.ncbi.nlm.nih.gov/12011050

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