N3-Methyluridine and 2′-O-Alkyl/2′-Fluoro-N3-methyluridine functionalized nucleic acids improve nuclease resistance while maintaining duplex geometry

Autor: Sahoo, Avijit, Das, Gourav, Ghosh, Atanu, Shivappa Bagale, Siddharam, Kumar Choudhary, Nishant, Harikrishna, S., Sinha, Surajit, Gore, Kiran R.

Publikováno v: In Bioorganic & Medicinal Chemistry 15 February 2024 100

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Synthesis and Structural Analysis of N³‐Methyluridine and 2'‐Alkoxy/Fluoro‐N³‐Methyluridine Nucleosides by Using NMR Spectroscopy, X‐Ray Crystallography, and Computational Methods.

Autor: Sahoo, Avijit¹ (AUTHOR), Das, Gourav¹ (AUTHOR), Choudhary, Nishant Kumar¹ (AUTHOR), Harikrishna, S.² (AUTHOR), Gore, Kiran R.¹ (AUTHOR) kiran@chem.iitkgp.ac.in

Publikováno v: ChemistrySelect. 6/26/2023, Vol. 8 Issue 24, p1-10. 10p.

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2'- O -Alkyl- N ³ -Methyluridine Functionalized Passenger Strand Improves RNAi Activity by Modulating the Thermal Stability.

Autor: Sahoo A; Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India., Gupta S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Das G; Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India., Ghosh A; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India., Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Gore KR; Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 16; Vol. 15 (8), pp. 1250-1259. Date of Electronic Publication: 2024 Jul 16 (Print Publication: 2024).