Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sahnila Enam"'
Publikováno v:
Journal of Virology. 78:3462-3469
B lymphocytes are known as a potential site for latency and reactivation of the human neurotropic polyomavirus, JC virus (JCV). In light of recent studies on the oncogenicity of JCV and the transforming ability of the JCV early protein, T antigen, we
Autor:
Kamel Khalili, Jessica Otte, Sahnila Enam, Luis Del Valle, Jennifer Gordon, Sujatha Radhakrishnan
Publikováno v:
Journal of Virology. 77:10638-10644
Cell-type-specific transcription of the JC virus (JCV) promoter in glial cells initiates a series of events leading to viral replication in the brain and the development of the fatal demyelinating disease progressive multifocal leukoencephalopathy (P
Autor:
Luis Del Valle, Jin Ying Wang, Krzysztof Reiss, Kamel Khalili, Sahnila Enam, Adam Lassak, Francesca Peruzzi, Sidney Croul
Publikováno v:
Journal of Biological Chemistry. 277:17231-17238
Insulin receptor substrate 1 (IRS-1) is the major signaling molecule for the insulin and insulin-like growth factor I receptors, which transduces both metabolic and growth-promoting signals, and has transforming properties when overexpressed in the c
Autor:
Martha Assimakopoulou, Sahnila Enam, Jennifer Gordon, Kamel Khalili, Sidney Croul, Serena Delbue, Luis Del Valle, Selvajothi Abraham, Christos D. Katsetos, Sujatha Radhakrishnan
Publikováno v:
Scopus-Elsevier
Background: The human neurotropic polyomavirus, JCV, contains an open reading frame within the late region of the viral genome that encodes a 71-amino-acid protein, agnoprotein. Because accumulating evidence supports an association between JCV infect
Publikováno v:
Experimental Cell Research. 265:221-233
Glioblastoma multiforme is a highly malignant and anaplastic tumor of the central nervous system representing more than 50% of all malignant gliomas. The cell origin of this highly undifferentiated tumor remains obscure, although it is postulated tha
Publikováno v:
ResearcherID
Examination of the primary tumor of glioblastoma multiforme and its recurrence for their association with JC virus revealed that, while the viral genome is present in both initial and recurrent tumors, expression of the viral oncoprotein T-antigen oc
Publikováno v:
Anticancer research. 26(2A)
Recently, the genome of the human polyomavirus, JC (JCV), and expression of its early and late regulatory proteins (T-antigen and agnoprotein) have been demonstrated in neoplastic cells of colonic cancer cases.Regulation of JCV was investigated in a
Autor:
Luis Del Valle, Kamel Khalili, Sahnila Enam, Matthew Q. Bromer, Rebecca M. Thomas, Martyn K. White, Henry P. Parkman, Sergio Piña Oviedo
Publikováno v:
Cancer. 103(3)
BACKGROUND The human polyomavirus JC virus (JCV) causes progressive multifocal leukoencephalopathy. Subclinical infection with JCV occurs in 85–90% of the population worldwide. The virus usually remains latent but can reactivate under immunosuppres
Publikováno v:
Archives of pathologylaboratory medicine. 128(3)
Context.—Progressive multifocal leukoencephalopathy is a fatal demyelinating disease of the central nervous system frequently seen in patients with impaired immune systems, particularly acquired immunodeficiency syndrome. JC virus (JCV), a human ne
Autor:
Sahnila, Enam, Luis, Del Valle, César, Lara, Dai-Di, Gan, Carlos, Ortiz-Hidalgo, Juan P, Palazzo, Kamel, Khalili
Publikováno v:
Cancer research. 62(23)
Infection of the gastrointestinal tract by the human polyomavirus, JCV, which has been frequently detected in raw urban sewage, can occur via intake of contaminated water and food. In light of earlier reports on the tumorigenecity of JCV, we investig