Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sahn Ho Kim"'
Autor:
Vidyavathi Reddy, Asm Iskander, Clara Hwang, George Divine, Mani Menon, Evelyn R Barrack, G Prem-Veer Reddy, Sahn-Ho Kim
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0211090 (2019)
Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate
Externí odkaz:
https://doaj.org/article/607ad49b375c445eb2d9bad612ef676d
Publikováno v:
The Prostate. 82(2)
BACKGROUND Despite multiple treatment advances for castration-resistant prostate cancer (CRPC), there are currently no curative therapies and patients ultimately to succumb to the disease. Docetaxel (DTX) is the standard first-line chemotherapy for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12dc8a7c22fafc3e9ad67bf29e00ea9
https://pubmed.ncbi.nlm.nih.gov/34672379
https://pubmed.ncbi.nlm.nih.gov/34672379
Autor:
Shalini Murthy, Min Wu, V Uma Bai, Zizheng Hou, Mani Menon, Evelyn R Barrack, Sahn-Ho Kim, G Prem-Veer Reddy
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56692 (2013)
BACKGROUND: The androgen receptor (AR) plays a critical role in the proliferation of prostate cancer cells. However, its mechanism of action in proliferation remains unknown. An understanding of the mechanism of AR action in proliferation may lead to
Externí odkaz:
https://doaj.org/article/91e1720d030b4b8b8a29df0ed72a75bd
Autor:
Nausica Arnoult, Caroline Schluth-Bolard, Anne Letessier, Irena Drascovic, Rachida Bouarich-Bourimi, Judith Campisi, Sahn-Ho Kim, Amina Boussouar, Alexandre Ottaviani, Frédérique Magdinier, Eric Gilson, Arturo Londoño-Vallejo
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000920 (2010)
The mechanisms governing telomere replication in humans are still poorly understood. To fill this gap, we investigated the timing of replication of single telomeres in human cells. Using in situ hybridization techniques, we have found that specific t
Externí odkaz:
https://doaj.org/article/3e341172847d40159be7b61dc626ac57
Autor:
Evelyn R. Barrack, Asm Iskander, Clara Hwang, Sahn-Ho Kim, Mani Menon, George Divine, Vidyavathi Reddy, G. Prem Veer Reddy
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0211090 (2019)
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PLoS ONE
BASE-Bielefeld Academic Search Engine
PLoS ONE
Telomere stability is important for cell viability, as cells with telomere DNA damage that is not repaired do not survive. We reported previously that androgen receptor (AR) antagonist induces telomere DNA damage in androgen-sensitive LNCaP prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6096cd53cd106414bc6c74b341f1613f
https://doaj.org/article/607ad49b375c445eb2d9bad612ef676d
https://doaj.org/article/607ad49b375c445eb2d9bad612ef676d
Autor:
Vidyavathi Reddy, Nicholas Ciavattone, Nathan McKenty, Mani Menon, Sahn Ho Kim, G. Prem Veer Reddy, Evelyn R. Barrack, Min Wu
Publikováno v:
Journal of Biological Chemistry. 290:25522-25533
Androgen receptor (AR) plays a role in maintaining telomere stability in prostate cancer cells, as AR inactivation induces telomere dysfunction within 3 h. Since telomere dysfunction in other systems is known to activate ATM (ataxia telangiectasia mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e9d457a3a3ca8f1dabf63bdcd67097
https://doi.org/10.1074/jbc.m115.671404
https://doi.org/10.1074/jbc.m115.671404
Autor:
Evelyn R. Barrack, M. Menon, Junying Zhou, Vidyavathi Reddy, G. Prem Veer Reddy, Sahn Ho Kim, Michelle Richardson
Publikováno v:
Aging (Albany NY)
Telomeres protect the ends of linear chromosomes from being recognized as damaged DNA, and telomere stability is required for genome stability. Here we demonstrate that telomere stability in androgen receptor (AR)-positive LNCaP human prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5a0d6499e2b524b41f6c9bef0ea132
https://doi.org/10.18632/aging.100524
https://doi.org/10.18632/aging.100524
Autor:
Kannagi Chinnakannu, Evelyn R. Barrack, Mani Menon, Sahn Ho Kim, V. Uma Bai, Shalini Murthy, G. Prem Veer Reddy, Arun Sivanandam
Publikováno v:
Journal of Cellular Physiology. 226:1889-1896
Prostate cancer is the most frequently diagnosed non-skin cancer and second leading cause of cancer deaths in American men (Jemal et al., 2009). Androgen, by activating the androgen receptor (AR), plays a pivotal role in prostate cancer cell prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62341f9547540e62914c6b71c5da41a1
https://doi.org/10.1002/jcp.22516
https://doi.org/10.1002/jcp.22516
Autor:
Denise P. Muñoz, Judith Campisi, Jean-Philippe Coppe, Robert Teachenor, Victoria Chu, Albert R. Davalos, Francis Rodier, Eric Campeau, Dipa Bhaumik, Sahn Ho Kim, Christian Beauséjour, Oanh Le
Publikováno v:
Journal of Cell Science. 124:68-81
DNA damage can induce a tumor suppressive response termed cellular senescence. Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other proteins and harbor persistent nuclear foci that contain DNA damage response (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01c0b47379adf08125e33226e14335c
https://doi.org/10.1242/jcs.071340
https://doi.org/10.1242/jcs.071340