P06-21 Multiparametric in vitro assays combined with high-throughput RNA sequencing for cardiotoxicity risk assessment and mechanistic insight

Autor: Llewellyn, S., Rosell-Hidalgo, A., Bruhn, C., Headspith, K., Samatov, T., Hackmann, A., Aquino, G.R., dos Reis, M. Fernandes, Rex, R., Yuezak, D., Vogeley, C., Sahini, N., Goussarov, G., Galatenko, V., Fritsch, R., Walker, P.

Publikováno v: In Toxicology Letters September 2024 399 Supplement 2:S160-S160

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Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.

Autor: Sohail A; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Iqbal AA; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Sahini N; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Chen F; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Tantawy M; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Hormones Department, Medical Research and Clinical Studies Institute, National Research Center, Dokki, Giza, Egypt.; Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Center, Dokki, Giza, Egypt., Waqas SFH; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Winterhoff M; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Ebensen T; Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Schultz K; Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany., Geffers R; Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany., Schughart K; Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.; University of Veterinary Medicine Hannover, Hannover, Germany.; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America., Preusse M; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany., Shehata M; Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Bähre H; Research Core Unit Metabolomics, Hannover Medical School, Hannover, Germany., Pils MC; Mouse Pathology Platform, Helmholtz Centre for Infection Research, Braunschweig, Germany., Guzman CA; Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany., Mostafa A; Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Pleschka S; Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany.; German Center for Infection Research (DZIF) partner site Giessen, Germany., Falk C; Department of Transplantation Immunology, Hannover Medical School, Hannover, Germany., Michelucci A; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Pessler F; Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.; TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.; Centre for Individualised Infection Medicine, Hannover, Germany.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 Jan 13; Vol. 18 (1), pp. e1010219. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2022).

Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome.

Autor: Hu, Penghui¹ (AUTHOR), Li, Huiyi² (AUTHOR), Ji, Zemin³ (AUTHOR), Jing, Weijia³ (AUTHOR), Li, Zihan³ (AUTHOR), Yu, Sujun³ (AUTHOR), Shan, Xiao⁴ (AUTHOR), Cui, Yan³ (AUTHOR), Wang, Baochen³ (AUTHOR), Dong, Hongyuan³ (AUTHOR), Zhou, Yanzhao^5,6 (AUTHOR), Wang, Zhe⁴ (AUTHOR), Xiong, Hui³ (AUTHOR), Zhang, Xiaomei⁴ (AUTHOR), Li, Hui-chieh⁴ (AUTHOR), Wang, Jinrong³ (AUTHOR), Tang, Jiuzhou³ (AUTHOR), Wang, Ting⁷ (AUTHOR), Xie, Keliang⁸ (AUTHOR) xiekeliang2009@hotmail.com, Liu, Yuping⁴ (AUTHOR) 18981838972@163.com

Publikováno v: PLoS Pathogens. 12/18/2024, Vol. 20 Issue 12, p1-26. 26p.

Genomics of human NAFLD: Lack of data reproducibility and high interpatient variability in drug target expression as major causes of drug failures.

Autor: Tang S; Centre for Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany., Borlak J

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Oct 01; Vol. 80 (4), pp. 901-915. Date of Electronic Publication: 2024 Feb 15.