Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Sahil Adriouch"'
Autor:
Catalina Abad, Mélanie Demeules, Charlotte Guillou, Henri Gondé, Rachid Zoubairi, Yossan-Var Tan, Carolina Pinto-Espinoza, Waldemar Schäfer, Anna Marei Mann, Valérie Vouret-Craviari, Friedrich Koch-Nolte, Sahil Adriouch
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic effects, have been developed. Adeno-associated virus (AAV)-mediated gene
Externí odkaz:
https://doaj.org/article/a3c490df818f4f30a4f057600fb6ee07
Autor:
Martin Bentler, Romain Hardet, Moritz Ertelt, Daniela Rudolf, Dorota Kaniowska, Andreas Schneider, Florian W.R. Vondran, Clara T. Schoeder, Marion Delphin, Julie Lucifora, Michael Ott, Ulrich T. Hacker, Sahil Adriouch, Hildegard Büning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 576-592 (2023)
De novo immune responses are considered major challenges in gene therapy. With the aim to lower innate immune responses directly in cells targeted by adeno-associated virus (AAV) vectors, we equipped the vector capsid with a peptide known to interfer
Externí odkaz:
https://doaj.org/article/653f4c03268045f68435d394aae772b1
Autor:
Ann-Christin Franke, Romain Hardet, Lisa Prager, Martin Bentler, Mélanie Demeules, Philipp John-Neek, Nico Martin Jäschke, Teng Cheong Ha, Ulrich Thorsten Hacker, Sahil Adriouch, Hildegard Büning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 238-253 (2023)
Immunotherapy has significantly improved treatment outcomes in various cancer entities. To enhance immunogenicity and efficacy, and to further broaden its applicability, co-administration of anti-tumor vaccines is considered as a promising strategy.
Externí odkaz:
https://doaj.org/article/60289b2c07f7465484685690b5e11a75
Autor:
Mélanie Demeules, Allan Scarpitta, Romain Hardet, Henri Gondé, Catalina Abad, Marine Blandin, Stephan Menzel, Yinghui Duan, Björn Rissiek, Tim Magnus, Anna Marei Mann, Friedrich Koch-Nolte, Sahil Adriouch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor. ATP c
Externí odkaz:
https://doaj.org/article/36e4c57c3cd8436f9f1c3d6f35cb19ff
Autor:
Carolina Pinto-Espinoza, Charlotte Guillou, Björn Rissiek, Maximilian Wilmes, Ehsan Javidi, Nicole Schwarz, Marten Junge, Friedrich Haag, Nastassia Liaukouskaya, Nicola Wanner, Annette Nicke, Catelijne Stortelers, Yossan-Var Tan, Sahil Adriouch, Tim Magnus, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an
Externí odkaz:
https://doaj.org/article/386f3b67689741c29d0bc06c088e84e7
Autor:
Ronald Sluyter, Sahil Adriouch, Stephen J. Fuller, Annette Nicke, Reece A. Sophocleous, Debbie Watson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8225 (2023)
The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of P2X7 and helped to establish the numerous physiological and pathophysio
Externí odkaz:
https://doaj.org/article/c438b8e4d86c48c8b331049e80db42fc
Autor:
Sahil Adriouch, Pablo Pelegrin
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 6, Pp n/a-n/a (2022)
Inflammasomes are multiprotein complexes that signal by oligomerizing the apoptosis speck‐like protein with caspase recruitment and activator domain (ASC) and are involved in multiple inflammatory, metabolic and degenerative diseases. Pharmacologic
Externí odkaz:
https://doaj.org/article/93540582046741f8a1be5d9bafe769fc
Autor:
Virgilia Sahiri, Jonathan Caron, Elena Roger, Christophe Desterke, Khalil Ghachem, Inna Mohamadou, Justine Serre, Niki Prakoura, Soraya Fellahi, Sandrine Placier, Sahil Adriouch, Lu Zhang, Christos E. Chadjichristos, Christos Chatziantoniou, Hans Kristian Lorenzo, Jean-Jacques Boffa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2723 (2023)
Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease and remains without specific treatment. To identify new events during FSGS progression, we used an experimental model of FSGS associated with nephroangiosclerosis i
Externí odkaz:
https://doaj.org/article/51c8b741c93049e1bce700df639423a8
Autor:
Laetitia Douguet, Serena Janho dit Hreich, Jonathan Benzaquen, Laetitia Seguin, Thierry Juhel, Xavier Dezitter, Christophe Duranton, Bernhard Ryffel, Jean Kanellopoulos, Cecile Delarasse, Nicolas Renault, Christophe Furman, Germain Homerin, Chloé Féral, Julien Cherfils-Vicini, Régis Millet, Sahil Adriouch, Alina Ghinet, Paul Hofman, Valérie Vouret-Craviari
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A limited percentage of patients with non-small cell lung cancer respond to immunotherapy. Here the authors show that HEI3090, a chemical positive modulator of the purinergic P2RX7 receptor, promotes IL-18 mediated anti-tumor immune responses and sen
Externí odkaz:
https://doaj.org/article/d9f2cc20554a4d0e92405e7e329a31b4
Autor:
Anna Marei Eichhoff, Kathleen Börner, Birte Albrecht, Waldemar Schäfer, Natalie Baum, Friedrich Haag, Jakob Körbelin, Martin Trepel, Ingke Braren, Dirk Grimm, Sahil Adriouch, Friedrich Koch-Nolte
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 211-220 (2019)
A limiting factor for the use of adeno-associated viruses (AAVs) as vectors in gene therapy is the broad tropism of AAV serotypes, i.e., the parallel infection of several cell types. Nanobodies are single immunoglobulin variable domains from heavy ch
Externí odkaz:
https://doaj.org/article/dba14e69bc8b42e19b8f68057c149779