Výsledky vyhledávání - "Sahib J. Singh"

Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

Autor: Benjamin L. Morris, Dipankar Bandyopadhyay, Zaid Nawaz, Sudha Korwar, Priyadarshan K Damle, Sahib J. Singh, Francisco Zarate-Perez, Carlos Escalante, Michael J Dennis, Xiaoyan Deng, M. Michael Dcona, Keith C Ellis, William E. Royer, Steven R. Grossman

Publikováno v: Mol Pharmacol

C-terminal binding proteins (CtBP1/2) are oncogenic transcriptional coregulators and dehydrogenases often overexpressed in multiple solid tumors, including breast, colon, and ovarian cancer, and associated with poor survival. CtBPs act by repressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57ac73f5f618f55277ce3da631760f3
https://doi.org/10.1124/mol.118.114363

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Abstract 3204: Tryptophan 318/324, the target of C-terminal binding protein (CtBP) inhibitors, plays a critical role in CtBP enzymatic activity, oligomerization and transcriptional coregulation

Autor: Priyadarshan K. Damle, Sahib J. Singh, Michael Dennis, Benjamin L. Morris, William E. Royer, Keith C. Ellis, M. Michael Dcona, Francisco Zarate Perez, Zaid Nawaz, Steven R. Grossman

Publikováno v: Cancer Research. 77:3204-3204

C-terminal Binding Proteins (CtBP) 1 and 2 constitute a family of oncogenic transcriptional co-regulators overexpressed in tumor tissues that are associated with worse prognostic outcome and aggressive tumor characteristics in multiple cancer types.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caa8d668bcc7138f35ee65adbfda5922
https://doi.org/10.1158/1538-7445.am2017-3204

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