Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand

Autor: Makarawate, Pattarapong, Glinge, Charlotte, Khongphatthanayothin, Apichai, Walsh, Roddy, Mauleekoonphairoj, John, Amnueypol, Montawatt, Prechawat, Somchai, Wongcharoen, Wanwarang, Krittayaphong, Rungroj, Anannab, Alisara, Lichtner, Peter, Meitinger, Thomas, Tjong, Fleur V.Y., Lieve, Krystien V.V., Amin, Ahmad S., Sahasatas, Dujdao, Ngarmukos, Tachapong, Wichadakul, Duangdao, Payungporn, Sunchai, Sutjaporn, Boosamas, Wandee, Pharawee, Poovorawan, Yong, Tfelt-Hansen, Jacob, Tanck, Michael W.T., Tadros, Rafik, Wilde, Arthur A.M., Bezzina, Connie R., Veerakul, Gumpanart, Nademanee, Koonlawee

Publikováno v: In Heart Rhythm December 2020 17(12):2145-2153

A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand.

Autor: Walsh R; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., Mauleekoonphairoj J; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.)., Mengarelli I; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., Bosada FM; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., Verkerk AO; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (A.O.V., K.v.D., V.M.C.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., van Duijvenboden K; Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (A.O.V., K.v.D., V.M.C.)., Poovorawan Y; Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (Y.P., A.K.)., Wongcharoen W; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.)., Sutjaporn B; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.)., Wandee P; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.)., Chimparlee N; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.).; Department of Medicine, Piyavate Hospital, Bangkok, Thailand (N.C.)., Chokesuwattanaskul R; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.)., Vongpaisarnsin K; Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (K.V.).; Department of Center of Excellence in Forensic Genetics, Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (K.V., P.D.)., Dangkao P; Department of Center of Excellence in Forensic Genetics, Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (K.V., P.D.).; Forensic Serology and DNA, King Chulalongkorn Memorial Hospital and Thai Red Cross Society, Bangkok, Thailand (P.D.)., Wu CI; Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taiwan (C.-I.W.)., Tadros R; Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, Quebec, Canada (R.T.)., Amin AS; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Department of Clinical Cardiology, Heart Centre, Amsterdam University Medical Centre, location AMC, the Netherlands (A.S.A., K.V.V.L., P.G.P., A.A.M.W.)., Lieve KVV; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Department of Clinical Cardiology, Heart Centre, Amsterdam University Medical Centre, location AMC, the Netherlands (A.S.A., K.V.V.L., P.G.P., A.A.M.W.)., Postema PG; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Department of Clinical Cardiology, Heart Centre, Amsterdam University Medical Centre, location AMC, the Netherlands (A.S.A., K.V.V.L., P.G.P., A.A.M.W.)., Kooyman M; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., Beekman L; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., Sahasatas D; Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand (D.S., P.M.)., Amnueypol M; Department of Medicine, Faculty of Medicine at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. (M.A., T. Ngarmukos)., Krittayaphong R; Department of Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand. (R.K.)., Prechawat S; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.)., Anannab A; Department of Cardiovascular and Intervention, Central Chest Institute of Thailand, Nonthaburi, Thailand (A.A.)., Makarawate P; Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand (D.S., P.M.)., Ngarmukos T; Department of Medicine, Faculty of Medicine at Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. (M.A., T. Ngarmukos)., Phusanti K; Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakorn Ratchasima, Thailand (K.P.)., Veerakul G; Bangkok Heart Hospital, Bangkok General Hospital, Thailand (G.V., A.K.)., Kingsbury Z; Illumina Cambridge Ltd, Granta Park, Great Abington, Cambridge, UK (Z.K., T. Newington, U.M., M.T.R.)., Newington T; Illumina Cambridge Ltd, Granta Park, Great Abington, Cambridge, UK (Z.K., T. Newington, U.M., M.T.R.)., Maheswari U; Illumina Cambridge Ltd, Granta Park, Great Abington, Cambridge, UK (Z.K., T. Newington, U.M., M.T.R.)., Ross MT; Illumina Cambridge Ltd, Granta Park, Great Abington, Cambridge, UK (Z.K., T. Newington, U.M., M.T.R.)., Grace A; Department of Biochemistry, University of Cambridge, UK (A.G.)., Lambiase PD; Cardiology, Medicine, Barts Heart Centre, London, UK (P.D.L.).; Institute of Cardiovascular Science, Population Health, UCL, London, UK (P.D.L.)., Behr ER; Molecular and Clinical Sciences Research Institute, St. George's, University of London, UK (E.R.B.).; Cardiology Clinical Academic Group, St. George's University Hospitals NHS Foundation Trust, London, UK (E.R.B.)., Schott JJ; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Nantes Université, CHU Nantes, CNRS, INSERM, l'Institut du Thorax, Nantes, France (J.-J.S., R.R., J.B.)., Redon R; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Nantes Université, CHU Nantes, CNRS, INSERM, l'Institut du Thorax, Nantes, France (J.-J.S., R.R., J.B.)., Barc J; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Nantes Université, CHU Nantes, CNRS, INSERM, l'Institut du Thorax, Nantes, France (J.-J.S., R.R., J.B.)., Christoffels VM; Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (A.O.V., K.v.D., V.M.C.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.)., Wilde AAM; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.).; Department of Clinical Cardiology, Heart Centre, Amsterdam University Medical Centre, location AMC, the Netherlands (A.S.A., K.V.V.L., P.G.P., A.A.M.W.)., Nademanee K; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.).; Pacific Rim Electrophysiology Research Institute, Bumrungrad Hospital, Bangkok, Thailand (K.N.)., Bezzina CR; Department of Experimental Cardiology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands. (R.W., I.M., F.M.B., A.O.V., M.K., L.B., C.R.B.).; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., V.M.C., A.A.M.W., C.R.B.).; Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (R.W., I.M., F.M.B., A.O.V., A.S.A., K.V.V.L., P.G.P., M.K., L.B., J.-J.S., R.R., J.B., A.A.M.W., C.R.B.)., Khongphatthanayothin A; Department of Medicine, Center of Excellence in Arrhythmia Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (J.M., W.W., B.S., P.W., N.C., R.C., S.P., K.N., A.K.).; Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. (Y.P., A.K.).; Bangkok Heart Hospital, Bangkok General Hospital, Thailand (G.V., A.K.).

Publikováno v: Circulation [Circulation] 2024 Oct 11. Date of Electronic Publication: 2024 Oct 11.