The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing

Autor: Akansha S. Das, Emily C. Sherry, Robert M. Vaughan, Marian L. Henderson, Jacob Zieba, Katie L. Uhl, Olivia Koehn, Caleb P. Bupp, Surender Rajasekaran, Xiaopeng Li, Surya B. Chhetri, Sahar Nissim, Carol L. Williams, Jeremy W. Prokop

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the family have multiple exons that require splicing. Yet, the role

Externí odkaz: https://doaj.org/article/c07fd91f53d941d8a816a9e1ed070660

Germline Testing for Individuals with Pancreatic Adenocarcinoma and Novel Genetic Risk Factors

Autor: Anu, Chittenden, Sigurdis, Haraldsdottir, Ethan, Chen, Sahar, Nissim

Publikováno v: Hematology/Oncology Clinics of North America. 36:943-960

Germline genetic variants implicated in increasing lifetime risk of pancreatic cancer (PDAC) have been identified in ∼4% to 10% of cases. Clinical features such as family history have poor sensitivity in identifying carriers of these risk variants.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d58bbbde9dd2d05b0a2811d57ab3921
https://doi.org/10.1016/j.hoc.2022.07.008

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer

Autor: Joseph D. Mancias, Benjamin C. Jennings, John Hedgepeth, Carol L. Williams, J. Wade Harper, Jeremy W. Prokop, Andrew G. Cox, Matthew B. Greenblatt, Ophélia Maertens, Ellen L. Lorimer, Julia Wucherpfennig, Chinedu Ukaegbu, Jake Henderson, Karen Cichowski, Patrick Gonyo, Wolfram Goessling, Alec C. Kimmelman, Christopher A. Cassa, Xiaoxu Wang, Carol A. Fierke, Sebastian Gableske, Gad Getz, Ignaty Leshchiner, Joao A. Paulo, Yariv Houvras, Andrew J. Kim, Sapna Syngal, Bethany Unger, Shamil R. Sunyaev, Jerry R. Heidel, Sahar Nissim, Jill A. Rosenfeld, Anthony Brandt

Pancreatic ductal adenocarcinoma is an aggressive cancer with limited treatment options(1). Approximately 10% of cases exhibit familial predisposition, but causative genes are not known in most families(2). We perform whole-genome sequence analysis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb26e6738ff8dee621a271cc62953935
https://europepmc.org/articles/PMC7159804/

Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity

Autor: Sahar Nissim, Trista E. North, Lea Vedder Sheward, Wanda Kwan, Gregory M. Frechette, Virginie Esain, Kelli J. Carroll, Sarah Y. Liu, Wolfram Goessling, Mauricio Cortes

Publikováno v: Stem Cells. 33:2596-2612

Cannabinoids (CB) modulate adult hematopoietic stem and progenitor cell (HSPCs) function, however, impact on the production, expansion, or migration of embryonic HSCs is currently uncharacterized. Here, using chemical and genetic approaches targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbda1b2b21ffa8092d93b1a778a04db9
https://doi.org/10.1002/stem.2044

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

Autor: John M. Asara, Byung Cheon Lee, Andrew G. Cox, Kimberley J. Evason, Evan C. Lien, Sagar Chhangawala, Jerry R. Heidel, Bryan C. Dickinson, Yariv Houvras, Diane C. Saunders, Christopher J. Chang, Kristin K. Brown, Min Yuan, Allison Tsomides, Wolfram Goessling, Katie L. Hwang, Vadim N. Gladyshev, Andrew J. Kim, Sahar Nissim

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 38
Cox, AG; Tsomides, A; Kim, AJ; Saunders, D; Hwang, KL; Evason, KJ; et al.(2016). Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 113(38), E5562-E5571. doi: 10.1073/pnas.1600204113. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1sx0r2zs

© 2016, National Academy of Sciences. All rights reserved. Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-containing proteins (selenoproteins). Selenoprotein H (SepH) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615584a446e33e142cd585c9b2072199
https://escholarship.org/uc/item/1sx0r2zs