Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Sahar M. Abou-Seri"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract In the current study, we designed and synthesized a series of new quinoline derivatives 10a-p as antiproliferative agents targeting cancer through inhibition of VEGFR-2. Preliminary molecular docking to assess the interactions of the designe
Externí odkaz:
https://doaj.org/article/fa84e6d1b71d42208b3a605f3cb0e6d6
Autor:
Zainab M. Elsayed, Hadia Almahli, Alessio Nocentini, Andrea Ammara, Claudiu T. Supuran, Wagdy M. Eldehna, Sahar M. Abou-Seri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
As part of our ongoing endeavour to identify novel inhibitors of cancer-associated CA isoforms IX and XII as possible anticancer candidates, here we describe the design and synthesis of small library of 2-aryl-quinazolin-4-yl aminobenzoic acid deriva
Externí odkaz:
https://doaj.org/article/36ea1b77452c46689044831948b95c9b
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract To exploit the advantageous properties of approved drugs to hasten anticancer drug discovery, we designed and synthesized a series of fluoroquinolone (FQ) analogs via functionalization of the acid hydrazides of moxifloxacin, ofloxacin, and c
Externí odkaz:
https://doaj.org/article/0be48dc5dceb439eae7cb8c4c30bb271
Autor:
Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed, Sahar M. Abou-Seri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 563-572 (2022)
On account of its crucial role in the virus life cycle, SARS-COV-2 NSP13 helicase enzyme was exploited as a promising target to identify a novel potential inhibitor using multi-stage structure-based drug discovery approaches. Firstly, a 3D pharmacoph
Externí odkaz:
https://doaj.org/article/dfc6cfd0c7e74656b4564f0943aef227
Autor:
Zainab M. Elsayed, Wagdy M. Eldehna, Marwa M. Abdel-Aziz, Mahmoud A. El Hassab, Eslam B. Elkaeed, Tarfah Al-Warhi, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Eman R. Mohammed
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 384-392 (2021)
Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids (5a–m and 9a–c) as promising anti-tubercular and antibacterial agents.
Externí odkaz:
https://doaj.org/article/9a41c567d6f34b458504f67509a0e1aa
Autor:
Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 298-305 (2020)
Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfo
Externí odkaz:
https://doaj.org/article/ff8ba644da4c499a8fe3a841533c748c
Autor:
Rana M. El-Masry, Basma M. Essa, Adli A. Selim, Soad Z. El-Emam, Khaled O. Mohamed, Tamer M. Sakr, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1476 (2022)
A new series of 5-(4-chlorophenyl)-1,3,4-thiadiazole-based compounds featuring pyridinium (3), substituted piperazines (4a–g), benzyl piperidine (4i), and aryl aminothiazoles (5a–e) heterocycles were synthesized. Evaluation of the cytotoxicity po
Externí odkaz:
https://doaj.org/article/e55cd9a7e9de49b9baed1202a1f8ac82
Autor:
Eslam B. Elkaeed, Fadia S. Youssef, Ibrahim H. Eissa, Hazem Elkady, Aisha A. Alsfouk, Mohamed L. Ashour, Mahmoud A. El Hassab, Sahar M. Abou-Seri, Ahmed M. Metwaly
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6912 (2022)
In continuation of our antecedent work against COVID-19, three natural compounds, namely, Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278) were determined as the most promising SARS-CoV-2 main protease (Mpro) inhibitors among 310 nat
Externí odkaz:
https://doaj.org/article/8ef205f9b5c14a4595bdd8f72a3aac4e
Publikováno v:
Molecules, Vol 27, Iss 9, p 2709 (2022)
The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design, syn
Externí odkaz:
https://doaj.org/article/505ec722cbe64391804e455281470690
Autor:
Rana M. Abdelnaby, Heba S. Rateb, Omaima Ali, Ahmed S. Saad, Rania I. Nadeem, Sahar M. Abou-Seri, Kamilia M. Amin, Nancy S. Younis, Rasha Abdelhady
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 428 (2022)
Breast cancer is the most common malignancy worldwide; therefore, the development of new anticancer agents is essential for improved tumor control. By adopting the pharmacophore hybridization approach, two series of 7-hydroxyl-4-methylcoumarin hybrid
Externí odkaz:
https://doaj.org/article/27e4736af3a74bb7b9ae0ab0e2466af4