Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and prospective studies

Autor: Sandra Castro-Pearson, Sarah Samorodnitsky, Kaifeng Yang, Sahar Lotfi-Emran, Nicholas E. Ingraham, Carolyn Bramante, Emma K. Jones, Sarah Greising, Meng Yu, Brian T. Steffen, Julia Svensson, Eric Åhlberg, Björn Österberg, David Wacker, Weihua Guan, Michael Puskarich, Anna Smed-Sörensen, Elizabeth Lusczek, Sandra E. Safo, Christopher J. Tignanelli

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Significant progress has been made in preventing severe COVID-19 disease through the development of vaccines. However, we still lack a validated baseline predictive biologic signature for the development of more severe disease in both outpat

Externí odkaz: https://doaj.org/article/8c6ba0735d984f7a80f031a5f8cacf53

Developing A Baseline Metabolomic Signature Associated with COVID-19 Severity: Insights from Prospective Trials Encompassing 13 U.S. Centers

Autor: Kaifeng Yang, Zhiyu Kang, Weihua Guan, Sahar Lotfi-Emran, Zachary J. Mayer, Candace R. Guerrero, Brian T. Steffen, Michael A. Puskarich, Christopher J. Tignanelli, Elizabeth Lusczek, Sandra E. Safo

Publikováno v: Metabolites, Vol 13, Iss 11, p 1107 (2023)

Metabolic disease is a significant risk factor for severe COVID-19 infection, but the contributing pathways are not yet fully elucidated. Using data from two randomized controlled trials across 13 U.S. academic centers, our goal was to characterize m

Externí odkaz: https://doaj.org/article/93db071b8ad146948dd8a4df6514d4e6

Characterizing COVID-19 clinical phenotypes and associated comorbidities and complication profiles.

Autor: Elizabeth R Lusczek, Nicholas E Ingraham, Basil S Karam, Jennifer Proper, Lianne Siegel, Erika S Helgeson, Sahar Lotfi-Emran, Emily J Zolfaghari, Emma Jones, Michael G Usher, Jeffrey G Chipman, R Adams Dudley, Bradley Benson, Genevieve B Melton, Anthony Charles, Monica I Lupei, Christopher J Tignanelli

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0248956 (2021)

PurposeHeterogeneity has been observed in outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19). Identification of clinical phenotypes may facilitate tailored therapy and improve outcomes. The purpose of this study is to identify

Externí odkaz: https://doaj.org/article/373ddf5df38c43178a22bb6b5fa651fc

Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases

Autor: Robinson, Philip C., Bhana, Suleman, Liew, Jean W., Sufka, Paul H., Singh, Namrata, Howard, Richard A., Kim, Alfred H.J., Westrich-Robertson, Tiffany, Sirotich, Emily, Tsui, Edmund, Duarte-Garcia, Ali, Sparks, Jeffrey A., Tam, Herman, Jayatilleke, Arundathi, Konig, Maximilian F., Graef, Elizabeth R., Putman, Michael S., Syed, Reema H., Korsten, Peter, Mateus, Elsa, Sattui, Sebastian E., Wallace, Zachary S., Laura, Upton A., Adam, Kilian, Chock, Yu Pei Eugenia, White, Douglas W., Zamora, Geraldine T., Traboco, Lisa S., Patel, Aarat M., Grainger, Rebecca, Ugarte-Gil, Manuel F., Gianfrancesco, Milena A., Amigues, Isabelle, Sanchez-Alvarez, Catalina, Trupin, Laura, Jacobsohn, Lindsay R., Beesley, Richard P., Hoyer, Bimba F., Machado, Pedro M., Makan, Kavita, Gossec, Laure, Priyank, Chaudhary, Leipe, Jan, Wallace, Beth, Angeles-Han, Sheila T., Almaghlouth, Ibrahim A., Katherine, Wysham D., Padula, Anthony S., Berenbaum, Francis, Treemarcki, Erin M., Sinha, Rashmi, Lewandowski, Laura B., Webb, Kate, Young, Kristen J., Bulina, Inita, Herrera Uribe, Sebastian, Rubinstein, Tamar B., Nolan, Marc W., Ang, Elizabeth Y., Venuturupalli, Swamy R., Hausmann, Jonathan S., Dubreuil, Maureen, Pisoni, Cecilia N., Cosatti, Micaela A., Campos, Jose, Simard, Julia F., Conway, Richard, Peterson, Tiffany M., Harrison, Carly O., Felix, Christele, Richards, Dawn P., Proulx, Laurie, Akpabio, Akpabio A., Worthing, Angus B., Laidlaw, Lynn R., Reid, Pankti, Palmerlee, Candace A., Danila, Maria I., Sahar, Lotfi-Emran, Linh, Ngo Q., Agarwal, Arnav, Studenic, Paul, Liew, David F.L., Larche, Maggie J., Mingolla, Serena A.M., Zamora, Erick A., Angevare, Saskya S., Sinha, Rashmi R., Durrant, Karen L.W., Peirce, Andrea, Somers, Emily C., Cappelli, Laura C., Frankel, Brittany A., Kumar, Bharat, Silinsky Krupnikova, Sonia D., Rosario Vega, Jorge A., Frankovich, Jourdan, Fernandez-Ruiz, Ruth, Posada Velásquez, Marcela, Yeoh, Su-Ann, Marino, Maria, Nudel, Michal, Scott, Chrisiaan, Rodríguez, Cecilia, Martín Mancheño, Ana I., Seo, Philip, Gamboa-Cárdenas, Rocío V., Pimentel-Quiroz, Victor R., Reátegui-Sokolova, Cristina, Kihara, Mari, Lin, Chung M.A., Kattula, Dheera, Laila, Girgis, Carmona, Loreto, Wallace, John, Yazdany, Jinoos, Costello, Wendy, Gore-massy, Monique C., Tomasella, Laura-Ann, Kodek, Moré A., Hausmann, Jonathan S, Kennedy, Kevin, Simard, Julia F, Liew, Jean W, Sparks, Jeffrey A, Moni, Tarin T, Harrison, Carly, Larché, Maggie J, Levine, Mitchell, Sattui, Sebastian E, Semalulu, Teresa, Foster, Gary, Surangiwala, Salman, Thabane, Lehana, Beesley, Richard P, Durrant, Karen L, Mateus, Elsa F, Mingolla, Serena, Palmerlee, Candace A, Richards, Dawn P, Liew, David F L, Hill, Catherine L, Machado, Pedro M, Robinson, Philip C, Sufka, Paul, Wallace, Zachary S

Publikováno v: In The Lancet Rheumatology October 2021 3(10):e707-e714

Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa

Autor: J. Michael Stolley, Milcah C. Scott, Vineet Joag, Alexander J. Dale, Timothy S. Johnston, Flavia Saavedra, Noah V. Gavil, Sahar Lotfi-Emran, Andrew G. Soerens, Eyob Weyu, Mark J. Pierson, Mark C. Herzberg, Nu Zhang, Vaiva Vezys, David Masopust

Publikováno v: Journal of Experimental Medicine. 220

The oral mucosa is a frontline for microbial exposure and juxtaposes several unique tissues and mechanical structures. Based on parabiotic surgery of mice receiving systemic viral infections or co-housing with microbially diverse pet shop mice, we re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b54dcecb27e23324bd0a2811b199264f
https://doi.org/10.1084/jem.20221853