A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

Autor: Isabelle Bernard, Antoine Sacquin, Sahar Kassem, Mehdi Benamar, Céline Colacios, Mylène Gador, Corine Pérals, Nicolas Fazilleau, Abdelhadi Saoudi

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The guanine nucleotide exchange factor Vav1 is essential for transducing T cell receptor (TCR) signals and plays an important role in T cell development and activation. Previous genetic studies identified a natural variant of Vav1 characterized by th

Externí odkaz: https://doaj.org/article/1d172c4b362b47fd81003dd19e718073

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.

Autor: Sahar Kassem, Guillaume Gaud, Isabelle Bernard, Mehdi Benamar, Anne S Dejean, Roland Liblau, Gilbert J Fournié, Céline Colacios, Bernard Malissen, Abdelhadi Saoudi

Publikováno v: PLoS Genetics, Vol 12, Iss 7, p e1006185 (2016)

The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell development and activation. Our previous genetic studies identified a locus on rat chromosome 9 t

Externí odkaz: https://doaj.org/article/d8479a9b003e41b78eb0bbad0088f8e1

Theoretical studies of the excited electronic states of the molecule ScLi and its ions ScLi± with a feasibility study of laser cooling

Autor: Sahar Kassem, Israa Zeid, Mahmoud Korek

Publikováno v: Canadian Journal of Chemistry. 101:33-42

For the transition metal lithides ScLi and ScLi±, the adiabatic potential energy and the static and transition dipole moment curves of the low-lying electronic states in the representation 2 s+1Λ(+/−) have been investigated. The spectroscopic con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01ab4f23214aba97befc8691ad556458
https://doi.org/10.1139/cjc-2022-0134

RG6234: A Novel 2:1 GPRC5D T Cell Bispecific Antibody Exhibits Best in Class Potential for the Treatment of Multiple Myeloma As a Monotherapy and in Combination

Autor: Jan Eckmann, Tanja Fauti, Aintzane Zabaleta, Laura Blanco, Sahar Kassem, Nadege Carrié, Stefan Lorenz, Alejandro Carpy, Tony Christopeit, Georg Fertig, Luise Bernasconi, Marlene Biehl, Sarah Diggelmann, Melanie Knobloch, Maud Mayoux, Charles Dumontet, Bruno Paiva, Ludovic Martinet, Stéphane Leclair, Wei Xu, Christian Klein, Pablo Umaña

Publikováno v: Blood. 140:2091-2092

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0b708bcef465860aaa94df761933da6
https://doi.org/10.1182/blood-2022-157485

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

Autor: Cédric Auffray, Guilhem Lalle, Charlotte Pouchy, Yenkel Grinberg-Bleyer, David Sleurs, Harald Wajant, Gilles Marodon, Sylvie Grégoire, Yannis Lombardi, Bruno Lucas, Maryam Khosravi, Emilie Ronin, Gaëlle H. Martin, Noémie Chanson, Sahar Kassem, Benoît L. Salomon, Morgane Hilaire, Armanda Casrouge

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (13), pp.e2014043118. ⟨10.1073/pnas.2014043118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (13), pp.e2014043118. ⟨10.1073/pnas.2014043118⟩
Proc Natl Acad Sci U S A

International audience; CD4+Foxp3+ regulatory T (Treg) cells are central modulators of autoimmune diseases. However, the timing and location of Treg cell-mediated suppression of tissue-specific autoimmunity remain undefined. Here, we addressed these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8cd5b547be9be536e393ec27453a4f
https://hal.sorbonne-universite.fr/hal-03185017