Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Sahar El Aidy"'
Autor:
Jack Jansma, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles P. van Wezel, Pieter van den Abbeele, Saskia van Hemert, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not w
Externí odkaz:
https://doaj.org/article/aefc9eaf089d4395beb16aea36d020a3
Autor:
Barbora Waclawiková, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTIntestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its
Externí odkaz:
https://doaj.org/article/bfc4e2f6d78e4fee9419d2cb3d2f3e4a
Autor:
Jack Jansma, Anastasia Chrysovalantou Chatziioannou, Kitty Castricum, Saskia van Hemert, Sahar El Aidy
Publikováno v:
mSystems, Vol 8, Iss 5 (2023)
ABSTRACT The gut microbiota plays a crucial role in maintaining overall health and probiotics have emerged as a promising microbiota-targeted therapy for improving human health. However, the molecular mechanisms of probiotics action in general and th
Externí odkaz:
https://doaj.org/article/3cc32c7d07664d82b26067ea9c832bd1
Autor:
Marwa S. Mahdy, Ahmed F. Azmy, Tarek Dishisha, Wafaa R. Mohamed, Kawkab A. Ahmed, Ahmed Hassan, Sahar El Aidy, Ahmed O. El-Gendy
Publikováno v:
BMC Microbiology, Vol 23, Iss 1, Pp 1-22 (2023)
Abstract Background Irinotecan is a chemotherapeutic agent used to treat a variety of tumors, including colorectal cancer (CRC). In the intestine, it is transformed into SN-38 by gut microbial enzymes, which is responsible for its toxicity during exc
Externí odkaz:
https://doaj.org/article/863d07f2992e411683fd7bfed4699173
Autor:
Toon Anton Willem Scheurink, Jenny Borkent, Shiral S. Gangadin, Sahar El Aidy, Rene Mandl, Iris E. C. Sommer
Publikováno v:
Brain and Behavior, Vol 13, Iss 6, Pp n/a-n/a (2023)
Abstract Introduction The barrier function of the gut is important for many organs and systems, including the brain. If gut permeability increases, bacterial fragments may enter the circulation, giving rise to increased systemic inflammation. Increas
Externí odkaz:
https://doaj.org/article/7259eb3b12f24eb198fe168cbb9cd053
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Gut microbiota influences the clinical response of a wide variety of orally administered drugs. However, the underlying mechanisms through which drug–microbiota interactions occur are still obscure. Previously, we reported that tyrosine de
Externí odkaz:
https://doaj.org/article/0e431291b2654d0aa0852d1e827ffd3c
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The human gastrointestinal tract is home to trillions of microbes. Gut microbial communities have a significant regulatory role in the intestinal physiology, such as gut motility. Microbial effect on gut motility is often evoked by bioactive molecule
Externí odkaz:
https://doaj.org/article/ed03221865a04af4a86140f6478ce25e
Autor:
Pamela González-Dávila, Markus Schwalbe, Arpit Danewalia, René Wardenaar, Boushra Dalile, Kristin Verbeke, Sushil K Mahata, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The gut microbiota is in continuous interaction with the intestinal mucosa via metabolic, neuro-immunological, and neuroendocrine pathways. Disruption in levels of antimicrobial peptides produced by the enteroendocrine cells, such as catestatin, has
Externí odkaz:
https://doaj.org/article/4760df09ba4345199ca08f1a307ff95b
Autor:
Enric Domingo, Sahar El Aidy, Gary Hardiman, Carsten Krieg, Lukas M Weber, Bruno Fosso, Marinella Marzano, Monica M Olcina, Khalil Mallah, Mark D Robinson, Silvia Guglietta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background and aims The role of inflammatory immune responses in colorectal cancer (CRC) development and response to therapy is a matter of intense debate. While inflammation is a known driver of CRC, inflammatory immune infiltrates are a positive pr
Externí odkaz:
https://doaj.org/article/fc97c007bd8c47ffbf5e758117697cc1
Autor:
Jack Jansma, Sahar El Aidy
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract The human gut harbors an enormous number of symbiotic microbes, which is vital for human health. However, interactions within the complex microbiota community and between the microbiota and its host are challenging to elucidate, limiting dev
Externí odkaz:
https://doaj.org/article/d3db0d50099b4c088d997b240927e539