Dosage Compensation and Gene Expression of the X Chromosome in Sheep

Autor: Jingyue (Ellie) Duan, Kaleigh Flock, Nathanial Jue, Mingyuan Zhang, Amanda Jones, Sahar Al Seesi, Ion Mandoiu, Sambhu Pillai, Maria Hoffman, Rachel O’Neill, Steven Zinn, Kristen Govoni, Sarah Reed, Hesheng Jiang, Zongliang (Carl) Jiang, Xiuchun (Cindy) Tian

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 305-314 (2019)

Ohno’s hypothesis predicts that the expression of the single X chromosome in males needs compensatory upregulation to balance its dosage with that of the diploid autosomes. Additionally, X chromosome inactivation ensures that quadruple expression o

Externí odkaz: https://doaj.org/article/864b5ffcf0614b31a7f65df7c0eed917

Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses

Autor: Jingyue (Ellie) Duan, Mingyuan Zhang, Kaleigh Flock, Sahar Al Seesi, Ion Mandoiu, Amanda Jones, Elizabeth Johnson, Sambhu Pillai, Maria Hoffman, Katelyn McFadden, Hesheng Jiang, Sarah Reed, Kristen Govoni, Steve Zinn, Zongliang Jiang, Xiuchun (Cindy) Tian

Publikováno v: Epigenetics, Vol 13, Iss 8, Pp 793-807 (2018)

Genomic imprinting is an epigenetic phenomenon of differential allelic expression based on parental origin. To date, 263 imprinted genes have been identified among all investigated mammalian species. However, only 21 have been described in sheep, of

Externí odkaz: https://doaj.org/article/4fc04a181087431a85e83c12a0fe9af1

Dosage Compensation and Gene Expression of the X Chromosome in Sheep

Autor: Ion I. Mandoiu, Steven A. Zinn, Kaleigh Flock, H. Jiang, Nathanial Jue, Mingyuan Zhang, M. L. Hoffman, Jingyue Duan, Sahar Al Seesi, A. K. Jones, Zongliang Carl Jiang, Xiuchun Cindy Tian, S. M. Pillai, Rachel J. O’Neill, Kristen E Govoni, Sarah A Reed

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 1, Pp 305-314 (2019)
G3: Genes|Genomes|Genetics

Ohno’s hypothesis predicts that the expression of the single X chromosome in males needs compensatory upregulation to balance its dosage with that of the diploid autosomes. Additionally, X chromosome inactivation ensures that quadruple expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929d89d1ba068b5776cfe09e69b5fcef
https://doi.org/10.1534/g3.118.200815

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Autor: Zhiqin Huang, Pramod K. Srivastava, Song Liu, Jason A. Greenbaum, Dirk Jäger, Jiaqian Wang, Ognjen Milicevic, Willem-Jan Krebber, Barbara Schrörs, Sean Michael Boyle, Michal Bassani-Sternberg, Ana M. Mijalkovic Lazic, Amit A. Lugade, Kristen K. Dang, Han Si, Alessandro Sette, Jeffrey P. Ward, Irsan Kooi, Michael F. Princiotta, Begonya Comin-Anduix, Thierry Schuepbach, Pia Kvistborg, Julia Kodysh, William Chour, Vladimir B. Kovacevic, Jan H. Kessler, Ariella Sasson, Antoni Ribas, Brian Stevenson, Sriram Sridhar, Prateek Tanden, Robert D. Schreiber, Jason Perera, Kathleen C. F. Sheehan, Hira Rizvi, Sachet A. Shukla, Baikang Pei, Han Chang, Bo Li, Ion I. Mandoiu, Cristina Puig-Saus, Beatriz M. Carreno, Si Qiu, Jennifer M. Shelton, Patrick Jongeneel, Qiang Hu, Taha Merghoub, Matthew D. Hellmann, James P. Conway, Francisco Arcila, Ton N. Schumacher, Mathias Vormehr, Christopher A. Morehouse, Patrice Manning, Jonathon Blake, Pornpimol Charoentong, Angela Frentzen, Christopher A. Miller, Michael A. Kuziora, Bin Song, Lei Wei, Martin Löwer, Gabor Bartha, Justin Guinney, Niels Halama, Rolf Hilker, Yinong Sebastian, Veliborka Josipovic, Jason Harris, Geng Liu, Guilhem Richard, Arjun A. Rao, Nikola M. Skundric, Markus Mueller, Daniel K. Wells, Tatiana Shcheglova, Inka Zörnig, Weixuan Fu, John Sidney, Nadine Defranoux, Gabriela Steiner, Joseph D. Szustakowski, Arbel D. Tadmor, Maxim N. Artyomov, Jianmin Wang, George Coukos, Brandon W. Higgs, Milica R. Kojicic, Siranush Sarkizova, Daphne van Beek, Naibo Yang, Robert Ziman, Mignonette H. Macabali, Thomas Yu, Nicolas Guex, Nina Bhardwaj, Lorenzo F. Fanchi, Bjoern Peters, Christian Iseli, Song Wu, Maren Lang, Juliet Forman, Marit M. van Buuren, David Balli, Steven L. C. Ketelaars, Nir Hacohen, Ekaterina Esaulova, Maarten Slagter, Todd Creasy, Robert A. Petit, Yi-Hsiang Hsu, Ravi Gupta, Katie M. Campbell, Pascal Gellert, David Haussler, Jesse M. Zaretsky, Sofie R. Salama, Vanessa M. Hubbard-Lucey, Joel Greshock, Zeynep Kosaloglu Yalcin, Cornelis J. M. Melief, Priyanka Shah, Ioannis Xenarios, Nevena M. Ilic Raicevic, Andrew Lamb, Suchit Jhunjhunwala, Aly A. Khan, David Gfeller, James R. Heath, Richard Chen, Jia M. Chen, Alphonsus H. C. Ng, Elham Sherafat, Ana Belen Blazquez, Leo J. Lee, Beata Berent-Maoz, Cheryl Selinsky, Jasreet Hundal, Eduardo Cortes, Xengie Doan, Sahar Al Seesi, Adam Kolom, Fred Ramsdell, Nicolas Robine, Andrew J. Rech

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, there are no reference data to compare these approaches, and the param

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b788124c42a6ace5b9cb5efa2f3572c
https://resolver.caltech.edu/CaltechAUTHORS:20201019-121956456

Finding neoepitopes in mouse models of personalized cancer immunotherapy

Autor: Sahar Al Seesi, Ion I. Mandoiu, Fei Duan, Alok Das Mohapatra, Arpita P. Pawashe

Publikováno v: Frontiers in Biology. 11:366-375

Background Cancer immunotherapy uses one’s own immune system to fight cancerous cells. As immune system is hard-wired to distinguish self and non-self, cancer immunotherapy is predicted to target cancerous cells specifically, therefore is less toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbdc2aea143282c069f5c8dbf63d06c0
https://doi.org/10.1007/s11515-016-1422-2