Effects of YM087 and VPA985 on the T237M mutant receptor functionality in nephrogenic diabetes insipidus

Autor: Avcu Elif Merve, Erdem Tuncdemir Beril, Saglar Ozer Emel

Publikováno v: Türk Biyokimya Dergisi, Vol 49, Iss 5, Pp 685-690 (2024)

Mutations detected in the AVPR2 gene (arginine vasopressin type 2 receptor) are known to cause nephrogenic diabetes insipidus (NDI). Several pharmacological chaperones (PCs) target misfolded AVPR2 proteins and rescue them from the quality control sys

Externí odkaz: https://doaj.org/article/c428472c93614124b6fcb79836e494b3

Evaluation of pharmacochaperone-mediated rescue of mutant V2 receptor proteins

Autor: Erdem Tuncdemir, Beril, Mergen, Hatice, Saglar Ozer, Emel

Publikováno v: In European Journal of Pharmacology 15 December 2019 865

Investigation of Fibrillar Aggregates Formed by Pathogenic Pre-Pro-Vasopressin Mutants that Cause ADNDI.

Autor: Vaizoglu RD; Hacettepe University, Faculty of Science, Department of Biology, Molecular Biology Section, Ankara, Turkey., Erdem B; Hacettepe University, Faculty of Science, Department of Biology, Molecular Biology Section, Ankara, Turkey., Gul M; Inonu University, Faculty of Medicine, Basic Medical Sciences, Histology and Embryology Section, Malatya, Turkey., Acar C; Inonu University, Faculty of Arts and Science, Department of Molecular Biology and Genetics, Malatya, Turkey., Ozdemirel HO; Hacettepe University, Faculty of Science, Department of Biology, Molecular Biology Section, Ankara, Turkey., Saglar Ozer E; Hacettepe University, Faculty of Science, Department of Biology, Molecular Biology Section, Ankara, Turkey., Mergen H; Hacettepe University, Faculty of Science, Department of Biology, Molecular Biology Section, Ankara, Turkey.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Oct 25. Date of Electronic Publication: 2024 Oct 25.