Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Sagiv Shifman"'
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background The study of gene essentiality, which measures the importance of a gene for cell division and survival, is used for the identification of cancer drug targets and understanding of tissue-specific manifestation of genetic conditions
Externí odkaz:
https://doaj.org/article/b913fc1525e7474db4e6a62099036c10
Publikováno v:
Cells, Vol 13, Iss 6, p 540 (2024)
POGZ (Pogo transposable element derived with ZNF domain) is known to function as a regulator of gene expression. While variations in the POGZ gene have been associated with intellectual disabilities and developmental delays in humans, the exact patho
Externí odkaz:
https://doaj.org/article/7d96add757d245cb9636940aaa1e8b02
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz defi
Externí odkaz:
https://doaj.org/article/14ea55860cc94204933e8e502705deac
Autor:
Igor Mandric, Jeremy Rotman, Harry Taegyun Yang, Nicolas Strauli, Dennis J. Montoya, William Van Der Wey, Jiem R. Ronas, Benjamin Statz, Douglas Yao, Velislava Petrova, Alex Zelikovsky, Roberto Spreafico, Sagiv Shifman, Noah Zaitlen, Maura Rossetti, K. Mark Ansel, Eleazar Eskin, Serghei Mangul
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain. Here the authors report ImReP, a computational method that can extract detailed i
Externí odkaz:
https://doaj.org/article/c97227d196d24e78bdaa9613ff7b0b70
Autor:
Julie Chow, Matthew Jensen, Hajar Amini, Farhad Hormozdiari, Osnat Penn, Sagiv Shifman, Santhosh Girirajan, Fereydoun Hormozdiari
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability, developmental disability, and epilepsy are characterized by abnormal brain development that may affect cognition, learning, behavior, a
Externí odkaz:
https://doaj.org/article/02b18537ec4e431c8533a1420976ad36
Autor:
Shir Filo, Oshrat Shtangel, Noga Salamon, Adi Kol, Batsheva Weisinger, Sagiv Shifman, Aviv A. Mezer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
MRI has been used for the non-invasive imaging of human brain aging but is sensitive to both tissue molecular composition and water content. Here the authors present a quantitative MRI method that discriminates these factors and describe region-speci
Externí odkaz:
https://doaj.org/article/3cea5d86f3b244b58dabced82d0db6fd
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008497 (2020)
We introduce a novel methodology for describing animal behavior as a tradeoff between value and complexity, using the Morris Water Maze navigation task as a concrete example. We develop a dynamical system model of the Water Maze navigation task, solv
Externí odkaz:
https://doaj.org/article/07c20cfd10de4f8bb0447eeac8c112ea
Autor:
Serghei Mangul, Harry Taegyun Yang, Nicolas Strauli, Franziska Gruhl, Hagit T. Porath, Kevin Hsieh, Linus Chen, Timothy Daley, Stephanie Christenson, Agata Wesolowska-Andersen, Roberto Spreafico, Cydney Rios, Celeste Eng, Andrew D. Smith, Ryan D. Hernandez, Roel A. Ophoff, Jose Rodriguez Santana, Erez Y. Levanon, Prescott G. Woodruff, Esteban Burchard, Max A. Seibold, Sagiv Shifman, Eleazar Eskin, Noah Zaitlen
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract High-throughput RNA-sequencing (RNA-seq) technologies provide an unprecedented opportunity to explore the individual transcriptome. Unmapped reads are a large and often overlooked output of standard RNA-seq analyses. Here, we present Read Or
Externí odkaz:
https://doaj.org/article/d5953314c54a44c1a89d0b7809960987
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/86f6f8a5fa734315aa46b75ea5b936d2
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2217-2227 (2017)
Summary: Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they share common mechanisms. We studied genes with de novo mutati
Externí odkaz:
https://doaj.org/article/fb55db812dd749eb9669c694b6da1cf4