Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Sagi Snir"'
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2024)
Epigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age accelerati
Externí odkaz:
https://doaj.org/article/7993b398fa074937a0b107b14bc31d89
Autor:
Liudmilla Rubbi, Haoxuan Zhang, Junxi Feng, Christopher He, Patrick Kurnia, Prashansa Ratan, Aakash Tammana, Sabina House, Michael Thompson, Colin Farrell, Sagi Snir, Daniel Stahler, Elaine A. Ostrander, Bridgett M. vonHoldt, Matteo Pellegrini
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1497-1512 (2022)
Unlike genomes, which are static throughout the lifespan of an organism, DNA methylomes are dynamic. To study these dynamics, we developed quantitative models that measure the effect of multiple factors on DNA methylomes including, age, sex, weight,
Externí odkaz:
https://doaj.org/article/41c57f9c128b4033838660025f3248c2
Autor:
Sagi Snir
Publikováno v:
BMC Genomics, Vol 21, Iss S2, Pp 1-11 (2020)
Abstract Background DNA methylation is widely used as a biomarker in crucial medical applications as well as for human age prediction of very high accuracy. This biomarker is based on the methylation status of several hundred CpG sites. In a recent l
Externí odkaz:
https://doaj.org/article/dbd14bd85048439eac1b9b9d28d0369d
Publikováno v:
BMC Genomics, Vol 21, Iss S1, Pp 1-11 (2020)
Abstract Background Horizontal gene transfer (HGT) is the event of a DNA sequence being transferred between species not by inheritance. HGT is a crucial factor in prokaryotic evolution and is a significant source for genomic novelty resulting in anti
Externí odkaz:
https://doaj.org/article/30b22cd1481046d7b9222e527e62b271
Publikováno v:
Epigenetics, Vol 14, Iss 9, Pp 912-926 (2019)
Epigenetic changes during ageing have been characterized by multiple epigenetic clocks that allow the prediction of chronological age based on methylation status. Despite their accuracy and utility, epigenetic age biomarkers leave many questions abou
Externí odkaz:
https://doaj.org/article/5103be5003e44ac1a90857f7eaf860c0
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008454 (2020)
One of the hallmarks of cancer is the extremely high mutability and genetic instability of tumor cells. Inherent heterogeneity of intra-tumor populations manifests itself in high variability of clone instability rates. Analogously to fitness landscap
Externí odkaz:
https://doaj.org/article/24ce93a7dac94d01863e380a49978175
Autor:
Eliran Avni, Sagi Snir
Publikováno v:
BMC Genomics, Vol 19, Iss S6, Pp 19-29 (2018)
Abstract Background Deciphering the history of life on Earth has long been regarded as one of the most central tasks in biology. In past years, widespread discordance between the evolutionary histories of different groups of orthologous genes of prok
Externí odkaz:
https://doaj.org/article/18ef918440114439bf9c43f8937f8148
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0204322 (2018)
BACKGROUND:Pseudogenes are non-functional sequences in the genome with homologous sequences that are functional (i.e. genes). They are abundant in eukaryotes where they have been extensively investigated, while in prokaryotes they are significantly s
Externí odkaz:
https://doaj.org/article/eab9dfb24c8544f3a2253717b1696625
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 11, p e1005183 (2016)
In multiple studies DNA methylation has proven to be an accurate biomarker of age. To develop these biomarkers, the methylation of multiple CpG sites is typically linearly combined to predict chronological age. By contrast, in this study we apply the
Externí odkaz:
https://doaj.org/article/c2cc8e9fa6364d008e5f3eeb5488d712
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004408 (2015)
Horizontal gene transfer (HGT), the transfer of genetic material between organisms, is crucial for genetic innovation and the evolution of genome architecture. Existing HGT detection algorithms rely on a strong phylogenetic signal distinguishing the
Externí odkaz:
https://doaj.org/article/287068c6c4854d69bf2e1022ed49b8b4