SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release.

Autor: Sager RA; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Backe SJ; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Dunn DM; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Heritz JA; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Ahanin E; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Dushukyan N; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Panaretou B; School of Cancer and Pharmaceutical Sciences, Institute of Pharmaceutical Science, King's College London, London, SE1 9NQ, UK., Bratslavsky G; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Woodford MR; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Bourboulia D; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA., Mollapour M; Department of Urology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA. mollapom@upstate.edu.; Upstate Cancer Center, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA. mollapom@upstate.edu.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY, 13210, USA. mollapom@upstate.edu.

Publikováno v: EMBO reports [EMBO Rep] 2024 Nov; Vol. 25 (11), pp. 4636-4654. Date of Electronic Publication: 2024 Sep 20.

Second international symposium on the chaperone code, 2023.

Autor: Buchner J; Department of Bioscience, Technical University of Munich, D85748, Garching, Germany. Electronic address: johannes.buchner@tum.de., Alasady MJ; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA; Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Backe SJ; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA., Blagg BSJ; Department of Chemistry and Biochemistry, Warren Family Research Center for Drug Discovery and Development, University of Notre Dame, Notre Dame, IN, 46556, USA., Carpenter RL; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Bloomington, IN, 47405, USA; Medical Sciences, Indiana University School of Medicine, Bloomington, IN, 47405, USA; Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 47405, USA., Colombo G; Department of Chemistry, University of Pavia, 27100 Pavia, Italy., Gelis I; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., Gewirth DT; Department of Biochemistry & Molecular Biology, University of Massachusetts Amherst, Amherst, MA, 01003, USA., Gierasch LM; Department of Chemistry, University of Massachusetts Amherst, Amherst, MA, 01003, USA; Hauptman-Woodward Medical Research Institute, Buffalo, NY, 14203, USA., Houry WA; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6, Canada., Johnson JL; Department of Biological Sciences and the Center for Reproductive Biology, University of Idaho, Moscow, ID, 83844, USA., Kang BH; Department of Biological Sciences, Ulsan National Institutes of Science and Technology (UNIST), Ulsan, 44919, South Korea., Kao AW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, 94158, USA., LaPointe P; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA; Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada., Mattoo S; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN, 47907, USA., McClellan AJ; Division of Science and Mathematics, Bennington College, Bennington, VT, 05201, USA., Neckers LM; Center for Cancer Research, National Cancer Institute, Rockville, MD, 20892, USA., Prodromou C; Genome Damage and Stability Centre, University of Sussex, Brighton, BN1 9RQ, UK., Rasola A; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Sager RA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA., Theodoraki MA; Department of Biology, Arcadia University, Glenside, PA, 19038, USA., Truman AW; Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA., Truttman MC; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA; Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA., Zachara NE; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Bourboulia D; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA., Mollapour M; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA. Electronic address: mollapom@upstate.edu., Woodford MR; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, 13210, USA; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA. Electronic address: woodform@upstate.edu.

Publikováno v: Cell stress & chaperones [Cell Stress Chaperones] 2024 Feb; Vol. 29 (1), pp. 88-96. Date of Electronic Publication: 2024 Feb 03.

Genomic Profiles and Clinical Outcomes of Penile Squamous Cell Carcinoma With Elevated Tumor Mutational Burden.

Autor: Necchi A; Department of Medical Oncology, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Spiess PE; Department of GU Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Costa de Padua T; Department of Medical Oncology, IRCCS San Raffaele Hospital, Milan, Italy., Li R; Department of GU Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Grivas P; Division of Oncology, Department of Medicine, University of Washington, Seattle.; Fred Hutchinson Cancer Center, Seattle, Washington., Huang RSP; Foundation Medicine, Inc, Cambridge, Massachusetts., Lin DI; Foundation Medicine, Inc, Cambridge, Massachusetts., Danziger N; Foundation Medicine, Inc, Cambridge, Massachusetts., Ross JS; Foundation Medicine, Inc, Cambridge, Massachusetts.; SUNY Upstate Medical University, Syracuse, New York., Jacob JM; SUNY Upstate Medical University, Syracuse, New York., Sager RA; SUNY Upstate Medical University, Syracuse, New York., Basnet A; SUNY Upstate Medical University, Syracuse, New York., Li G; Foundation Medicine, Inc, Cambridge, Massachusetts., Graf RP; Foundation Medicine, Inc, Cambridge, Massachusetts., Pavlick DC; Foundation Medicine, Inc, Cambridge, Massachusetts., Bratslavsky G; SUNY Upstate Medical University, Syracuse, New York.

Publikováno v: JAMA network open [JAMA Netw Open] 2023 Dec 01; Vol. 6 (12), pp. e2348002. Date of Electronic Publication: 2023 Dec 01.

Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery.

Autor: Backe SJ; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Sager RA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Heritz JA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Wengert LA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Meluni KA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Aran-Guiu X; Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK., Panaretou B; School of Cancer and Pharmaceutical Sciences, Institute of Pharmaceutical Science, King's College London, London SE1 9NQ, UK., Woodford MR; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Prodromou C; Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK., Bourboulia D; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Mollapour M; Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: mollapom@upstate.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Jul 25; Vol. 42 (7), pp. 112807. Date of Electronic Publication: 2023 Jul 14.

Impact of Co-chaperones and Posttranslational Modifications Toward Hsp90 Drug Sensitivity.

Autor: Backe SJ; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA., Woodford MR; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA., Ahanin E; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA., Sager RA; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA., Bourboulia D; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA., Mollapour M; Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA. mollapom@upstate.edu.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA. mollapom@upstate.edu.; Upstate Cancer Center, SUNY Upstate Medical University, Syracuse, NY, USA. mollapom@upstate.edu.

Publikováno v: Sub-cellular biochemistry [Subcell Biochem] 2023; Vol. 101, pp. 319-350.